DOI . ORG {}

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We began analyzing https://link.springer.com/chapter/10.1007/82_2010_74, but it redirected us to https://link.springer.com/chapter/10.1007/82_2010_74. The analysis below is for the second page.

Title[redir]:
Hypoxia-Inducible Factors as Essential Regulators of Inflammation | SpringerLink
Description:
Myeloid cells provide important functions in low oxygen (O2) environments created by pathophysiological conditions, including sites of infection, inflammation, tissue injury, and solid tumors. Hypoxia-inducible factors (HIFs) are principle regulators of hypoxic...

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Education
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🏙️ Massive Traffic: 50M - 100M visitors per month

Based on our best estimate, this website will receive around 80,473,390 visitors per month in the current month.

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Keywords {🔍}

google, scholar, pubmed, cas, article, hypoxia, macrophages, cancer, hypoxiainducible, factor, tumor, expression, hifalpha, cell, inflammation, immunol, human, med, lee, simon, cells, lewis, chapter, biol, res, harris, progression, hypoxic, role, activation, macrophage, function, factors, gene, angiogenesis, hif, interleukin, alpha, kim, celeste, tumors, hifs, regulation, therapy, necrosis, factoralpha, johnson, usa, arthritis, privacy,

Topics {✒️}

nuclear factor-kappab-dependent pathway von hippel-lindau protein-independent hif-1alpha-dependent nf-kappab activity pi3k-hif-1alpha-vegf axis hypoxia-inducible factors hif-1alpha hypoxia-inducible factor-1α regulation hypoxia-inducible factor-2 alpha month download article/chapter hypoxia-inducible factor induction hif-dependent signalling events hypoxia-inducible factor 1alpha hypoxia inducible factor-1alpha hypoxia-inducible factor-1alpha desferrioxamine-stimulated hmc-1 cells hypoxia-induced neutrophil survival carboxyl-terminal transactivation activity tumor necrosis factor-alpha hif-1α promotes survival myd88-dependent il-6 production bone marrow-derived macrophages leukocyte-endothelial adhesion molecules lipopolysaccharide-induced sepsis cytokine-driven compensatory proliferation hif-1alpha expression regulates hypoxia-inducible factor hypoxia-inducible factor 1 myeloid cell-mediated inflammation tumour necrosis factor hypoxia-inducible factors hypoxia-inducible factors 1 o2-regulated prolyl hydroxylation hif-1-dependent induction nf-kappab activation privacy choices/manage cookies macrophage inflammatory protein-2 myeloid cell function tumor necrosis factor device instant download septic shock syndrome anti-cancer therapy important transcriptional effectors editor information editors adjuvant-induced arthritis chapter diverse effects il-10 increases lethality dendritic cells liver parenchymal cells deliver gene therapy hif-1 transcriptional activity myeloid cell inflammation

Questions {❓}

Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow?

Schema {🗺️}

ScholarlyArticle:
      headline:Hypoxia-Inducible Factors as Essential Regulators of Inflammation
      pageEnd:120
      pageStart:105
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      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
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         name:Diverse Effects of Hypoxia on Tumor Progression
         isbn:
            978-3-642-13329-9
            978-3-642-13328-2
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      author:
            name:Hongxia Z. Imtiyaz
            affiliation:
                  name:University of Pennsylvania
                  address:
                     name:Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:Howard Hughes Medical Institute
                  address:
                     name:Howard Hughes Medical Institute, Chevy Chase, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M. Celeste Simon
            affiliation:
                  name:University of Pennsylvania
                  address:
                     name:Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:Howard Hughes Medical Institute
                  address:
                     name:Howard Hughes Medical Institute, Chevy Chase, USA
                     type:PostalAddress
                  type:Organization
                  name:University of Pennsylvania School of Medicine
                  address:
                     name:Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, USA
                     type:PostalAddress
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            email:[email protected]
            type:Person
      keywords:Rheumatoid Arthritis Pathogenesis, Aryl Hydrocarbon Receptor Nuclear Translocator, Rheumatoid Arthritis Joint, Macrophage Gene Expression, Endothelial Monocyte Activate Polypeptide
      description:Myeloid cells provide important functions in low oxygen (O2) environments created by pathophysiological conditions, including sites of infection, inflammation, tissue injury, and solid tumors. Hypoxia-inducible factors (HIFs) are principle regulators of hypoxic adaptation, regulating gene expression involved in glycolysis, erythropoiesis, angiogenesis, proliferation, and stem cell function under low O2. Interestingly, increasing evidence accumulated over recent years suggests an additional important regulatory role for HIFs in inflammation. In macrophages, HIFs not only regulate glycolytic energy generation, but also optimize innate immunity, control pro-inflammatory gene expression, mediate bacterial killing and influence cell migration. In neutrophils, HIF-1α promotes survival under O2-deprived conditions and mediates blood vessel extravasation by modulating β 2 integrin expression. Additionally, HIFs contribute to inflammatory functions in various other components of innate immunity, such as dendritic cells, mast cells, and epithelial cells. This review will dissect the role of each HIF isoform in myeloid cell function and discuss their impact on acute and chronic inflammatory disorders. Currently, intensive studies are being conducted to illustrate the connection between inflammation and tumorigenesis. Detailed investigation revealing interaction between microenvironmental factors such as hypoxia and immune cells is needed. We will also discuss how hypoxia and HIFs control properties of tumor-associated macrophages and their relationship to tumor formation and progression.
      datePublished:2010
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Book:
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      isbn:
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      name:Springer Berlin Heidelberg
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      address:
         name:Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, USA
         type:PostalAddress
      name:Howard Hughes Medical Institute
      address:
         name:Howard Hughes Medical Institute, Chevy Chase, USA
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            address:
               name:Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Howard Hughes Medical Institute
            address:
               name:Howard Hughes Medical Institute, Chevy Chase, USA
               type:PostalAddress
            type:Organization
      name:M. Celeste Simon
      affiliation:
            name:University of Pennsylvania
            address:
               name:Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Howard Hughes Medical Institute
            address:
               name:Howard Hughes Medical Institute, Chevy Chase, USA
               type:PostalAddress
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            name:University of Pennsylvania School of Medicine
            address:
               name:Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, USA
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PostalAddress:
      name:Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, USA
      name:Howard Hughes Medical Institute, Chevy Chase, USA
      name:Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, USA
      name:Howard Hughes Medical Institute, Chevy Chase, USA
      name:Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, USA
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