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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Social Networks
  9. External Links
  10. Analytics And Tracking
  11. Libraries
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We began analyzing https://www.spandidos-publications.com/10.3892/ijo.2013.2169, but it redirected us to https://www.spandidos-publications.com/10.3892/ijo.2013.2169. The analysis below is for the second page.

Title[redir]:
Serum miR-210 as a potential biomarker of early clear cell renal cell carcinoma
Description:
Early detection and treatment are critical in the management of renal cell carcinoma (RCC). However, there is no standard serum biomarker to facilitate early diagnosis or prognostic stratification in patients with RCC. Recent reports suggest that circulating microRNAs (miRNAs) have great potential as biomarkers for diagnosis and prognosis in patients with several types of cancers. Further, many studies using miRNA microarray analysis demonstrated that miR-210 expression in clear cell carcinoma (CCC), which is the largest subtype of RCC, was significantly upregulated in tumor tissue. Therefore, we investigated whether serum miR-210 could be a useful biomarker for the diagnosis and progression of CCC. This study included 34 CCC patients and 23 healthy controls (HC). First, we analyzed tissue miR-210 levels in tumor tissues and matched normal tissues from the 34 CCC patients. Second, we investigated the serum miR-210 levels in the 34 CCC patients and the 23 HC patients. Real-time polymerase chain reaction (PCR) was used to measure miRNA levels. Moreover, we examined the correlation between serum miR-210 levels and the clinicopathological parameters. Among patients with CCC, expression of miR-210 was higher in tumor tissues compared to normal tissues (P<0.001). Serum miR-210 levels were higher in CCC patients compared to HCs (P=0.001). Receiver operating characteristic (ROC) curve analysis showed an area under the ROC curve (AUC) of 0.77 (95% confidence interval, 0.65-0.89) and a sensitivity and specificity of 65 and 83%, respectively. In addition, there was no significant association between serum miR-210 levels and age, sex, tumor size or existence of metastasis at diagnosis among the 34 CCC patients. In conclusion, serum miR-210 upregulation may occur in the early stage of CCC and serum miR-210 can be a useful biomarker for early CCC in humans.

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  • Science

Content Management System {📝}

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How Does Doi.org Make Money? {💸}

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Keywords {🔍}

patients, serum, ccc, levels, cancer, article, view, google, scholar, pubmedncbi, tissues, cell, rcc, tumor, hcs, tissue, early, microrna, renal, expression, biomarker, carcinoma, circulating, micrornas, analysis, mirnas, studies, significantly, normal, samples, comparing, potential, diagnosis, mirna, study, higher, values, journal, biomarkers, sensitivity, normalized, oncology, detection, metastasis, breast, human, fig, information, total, cancers,

Topics {✒️}

quantitative real-time pcr protein-coding small rnas real-time pcr data quantitative reverse transcription-pcr recent reports suggest hypoxia-inducible factor 1α mirna-specific rt primers early-stage renal tumors 1019-6439 online issn home submit manuscript clear cell carcinoma stable blood-based markers real-time pcr oncology molecular renal cell carcinoma clinical oncology experimental final elution volume editor general information renal carcinoma cells dig dis sci tumor suppressor gene human peripheral blood previous reports mol cell cardiol rt reaction mixtures relative expression levels total pdf downloads natl cancer inst tumoral renal parenchyma assessed rna values nana-sinkam sp blood-based markers small renal masses measure mirna levels taqman microrna assay target gene networks receiver operating characteristic common urological neoplasm 5-year survival rate strictly intracellular molecules tottori university hospital receiver operator characteristic kruskal-wallis test high accuracy rate devita vt jr pogosova-agadjanyan el acute myocardial infarction bast rc jr male genital organs cancer cell lines

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External Links {🔗}(169)

Analytics and Tracking {📊}

  • Google Analytics
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Libraries {📚}

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