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Title[redir]:
Targeted Agents and Resistance Mechanism in Renal Cell Cancer - Bulletin of Urooncology
Description:
Targeted Agents and Resistance Mechanism in Renal Cell Cancer - Bulletin of Urooncology
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Keywords {🔍}
cell, treatment, resistance, renal, carcinoma, cells, cancer, tumor, patients, rcc, sunitinib, months, vegf, inhibitors, mtor, metastatic, gene, angiogenesis, expression, endothelial, study, phase, targeted, vhl, pathway, survival, shown, protein, ccrcc, mrcc, sorafenib, growth, genes, tki, group, factor, studies, everolimus, receptor, oncol, pathways, mechanisms, activation, tumors, molecular, increased, vegfr, iii, pfs, therapy,
Topics {✒️}
platelet-derived growth factor pi3k/akt/mtor pathway correlates metastatic renal-cell carcinoma pi3k/akt/mtor pathway plays von hippel-lindau gene advanced renal-cell carcinoma allowing cell-cell adhesion cytotoxic t-lymphocyte antigen-4 urooncology association e-issn tyrosine kinase inhibitors pro-angiogenic inflammatory cells induces ubiquitin-mediated proteolysis hand-foot skin reaction pd-1/pd-l1 inhibitors single nucleotide polymorphisms pro-angiogenic inflammation cells von hippel-lindau pi3k/akt/mtor pathway renal cell carcinoma renal-cell carcinoma pro-angiogenic factor c-met dual inhibitor wild-type vhl alleles renal cell carcinomas lysine-specific demethylase 5c plgfs/vegfr-1 complex strengthens cell-cell adhesion promotes tumor growth placental growth factor phase iii study detected hif-α protein neurotrophic factor receptor hgf/c-met acts prolonged progression-free survival alternative angiogenic pathway including primary resistance clear cell rcc phase ii study immune checkpoint inhibitors increased invasive feature increase epithelial-mesenchymal transition transient acquired resistance pro-angiogenic signals pro angiogenic signals phase ii trial pro-angiogenic factors anti-angiogenic therapy ras/mek/erk anti-tumor activity vhl defective tumors
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