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We are analyzing https://www.nature.com/articles/s41586-020-2418-2.

Title:
Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping | Nature
Description:
N4-acetylcytidine (ac4C) is an ancient and highly conserved RNA modification that is present on tRNA and rRNA and has recently been investigated in eukaryotic mRNA1–3. However, the distribution, dynamics and functions of cytidine acetylation have yet to be fully elucidated. Here we report ac4C-seq, a chemical genomic method for the transcriptome-wide quantitative mapping of ac4C at single-nucleotide resolution. In human and yeast mRNAs, ac4C sites are not detected but can be induced—at a conserved sequence motif—via the ectopic overexpression of eukaryotic acetyltransferase complexes. By contrast, cross-evolutionary profiling revealed unprecedented levels of ac4C across hundreds of residues in rRNA, tRNA, non-coding RNA and mRNA from hyperthermophilic archaea. Ac4C is markedly induced in response to increases in temperature, and acetyltransferase-deficient archaeal strains exhibit temperature-dependent growth defects. Visualization of wild-type and acetyltransferase-deficient archaeal ribosomes by cryo-electron microscopy provided structural insights into the temperature-dependent distribution of ac4C and its potential thermoadaptive role. Our studies quantitatively define the ac4C landscape, providing a technical and conceptual foundation for elucidating the role of this modification in biology and disease4–6. A method termed ac4C-seq is introduced for the transcriptome-wide mapping of the RNA modification N4-acetylcytidine, revealing widespread temperature-dependent acetylation that facilitates thermoadaptation in hyperthermophilic archaea.
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pubmed, article, acc, google, scholar, cas, data, rna, central, sites, kodakarensis, nature, cells, wildtype, misincorporation, supplementary, nat, cryoem, analysis, trna, res, accseq, human, research, sequence, mass, independent, shown, acetylation, rrna, distribution, protein, fig, cytidine, grown, identified, presented, modification, mrna, chemical, biol, ribosome, structure, samples, experiments, extended, schwartz, proteomics, acids, cerevisiae,

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nature portfolio journals permissions reprints nature portfolio privacy policy gsk-3β-regulated n-acetyltransferase 10 rna-seq libraries macro-porous polystyrene-divinylbenzene resins rna editing events quantitative cross-evolutionary mapping markerless gene editing advertising anti-ac4c immuno-northern blot n4-acetyl-2′-o-methylcytidine found coli ribosome–ef-tu complex social media wild-type hek-293t samples wild-type hek-293t cells acetyltransferase-deficient archaeal ribosomes index transcriptome-wide quantitative mapping hek-293t cells overexpressing intramural research program article sas-chen = 3 lc–ms/ms runs magnetic resonance research single-nucleotide resolution antibody cross-reactivity accounts european research council tmm-normalized read counts nature+ nature 520 nature 551 nature 583 nature cryo-em data collection ensemble cryo-em structure base-catalysed hydrolysis occurred lc–ms/ms experiments improved cryo-electron microscopy aldema sas-chen mass spectrometry-based identification cs-corrected cryo-em cryo-em density maps development previously published data single-particle electron cryomicroscopy moran shalev-benami cryo-em map density cancer research permissions

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      headline:Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping
      description:N4-acetylcytidine (ac4C) is an ancient and highly conserved RNA modification that is present on tRNA and rRNA and has recently been investigated in eukaryotic mRNA1–3. However, the distribution, dynamics and functions of cytidine acetylation have yet to be fully elucidated. Here we report ac4C-seq, a chemical genomic method for the transcriptome-wide quantitative mapping of ac4C at single-nucleotide resolution. In human and yeast mRNAs, ac4C sites are not detected but can be induced—at a conserved sequence motif—via the ectopic overexpression of eukaryotic acetyltransferase complexes. By contrast, cross-evolutionary profiling revealed unprecedented levels of ac4C across hundreds of residues in rRNA, tRNA, non-coding RNA and mRNA from hyperthermophilic archaea. Ac4C is markedly induced in response to increases in temperature, and acetyltransferase-deficient archaeal strains exhibit temperature-dependent growth defects. Visualization of wild-type and acetyltransferase-deficient archaeal ribosomes by cryo-electron microscopy provided structural insights into the temperature-dependent distribution of ac4C and its potential thermoadaptive role. Our studies quantitatively define the ac4C landscape, providing a technical and conceptual foundation for elucidating the role of this modification in biology and disease4–6. A method termed ac4C-seq is introduced for the transcriptome-wide mapping of the RNA modification N4-acetylcytidine, revealing widespread temperature-dependent acetylation that facilitates thermoadaptation in hyperthermophilic archaea.
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         Mass spectrometry
         RNA modification
         RNA sequencing
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