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Title[redir]:
Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly - PMC
Description:
Here we report the crystal structures of the Thermus thermophilus ribosome at 2.3-2.5Å-resolution, which have enabled a comprehensive modeling of rRNA modifications. The structures reveal contacts of modified nucleotides with mRNA and tRNAs or ...
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Keywords {🔍}
doi, rrna, modifications, ribosome, pmc, nucleotides, ribosomal, google, scholar, pubmed, article, fig, protein, modified, data, free, supplementary, mrna, rna, ribosomes, complex, contacts, tth, coli, structure, thermophilus, group, resolution, nlm, biol, structures, trnas, residues, electron, density, maps, refinement, form, table, base, subunit, ncbi, search, national, functional, methylation, translation, shown, trna, interactions,
Topics {✒️}
4fe-4s iron-sulfur cluster fo-fc map 70s-mrna-trnasa data collection electron density maps pmc beta search watson-crick base pairing single-stranded rrna segments a-site trna substrates numerous studies show comprehensive python-based system online methods purification [google scholar] 4 couple aminoacyl-trna accommodation text rrna nucleotides individual b-factor refinement advanced photon source license information pmcid 2’-o-methyl group ribosome strongly affect distorted rrna folds united states government p-site trna supplementary materials included online methods abundant group comprises ribosomal proteins s12 p212121 cell dimensions 2-c-methyl group grey mesh shows green mesh shows impair translational response peptide-exit tunnel peptide exit tunnel vapor diffusion method accession codes 4y4o ksga methyltransferase restructures nucleic acids res baxter-roshek jl previously unknown position inter-subunit bridges final edited form inter-subunit contacts data availability statements ribosomal proteins falling ribosomal rna modifications19 methyl-modified sites previous structural studies coli numbering system highly distorted helices peptidyl transferase loop
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