
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Landscape of the complete RNA chemical modifications in the human 80S ribosome - PMC
Description:
During ribosome biogenesis, ribosomal RNAs acquire various chemical modifications that ensure the fidelity of translation, and dysregulation of the modification processes can cause proteome changes as observed in cancer and inherited human ...
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Keywords {π}
rrna, human, doi, pubmed, google, scholar, rna, rrnas, ptms, pmc, supplementary, ribosome, article, sites, free, cells, analysis, modification, ptm, modifications, table, figure, acids, ribosomal, cell, fragments, nucleic, res, modified, structure, patients, nucleotide, yeast, taoka, mass, pseudouridylation, rnase, data, sequence, site, chemical, dkc, isobe, rnas, found, ribosomes, obtained, study, stoichiometry, nobe,
Topics {βοΈ}
macro-porous polystyrene-divinylbenzene resins reversed-phase liquid chromatography vitro transcribed g-13c10-labeled uk/tools/msa/clustalo/ epstein-barr virus transformed direct nanoflow lc-ms proper gene-targeting events uridine-13c9-labeled reference rnas /u-5d-labeled fragment sodium cytidine-13c9 5β²-triphosphate exhibit tissue-specific expression post-transcriptional rna modifications sodium guanosine-13c10 5β²-triphosphate pmc beta search sodium uridine-13c9 5β²-triphosphate uridine-13c9 5β²-triphosphate solution ms/ms rna spectra mass spectrometry-based method extremely gc-rich region nuclease-free water fine-tune ribosomal structure mass spectrometry-based identification vitro transcribed cytidine-13c9 power-law distribution Ο-characteristic signature ion cryo-electron microscopy heavy isotope-labeled fragment small-subunit ribosomal rna silnas-based quantitative analysis crispr/cas9 technique high-resolution structure silnas-based ptm analysis rna 2-o-methylated residues post-transcriptional modifications umps-deficient tk6 cells 6-d2-uridine labeled rnas 2β²-o-methylation/pseudouridylation reactions reversed-phase lc cytidine-13c9 5β²-triphosphate triethylammonium acetate buffer stable isotope labeling bone marrow failure full-length rrna silnas-based quantitation guanosine-13c10 5β²-triphosphate coding ribonucleic acids functionally important regions quantitative mass spectrometry autosomal dominant types default search parameters
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