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Keywords {🔍}

cancer, risk, factors, pubmed, article, google, scholar, intrinsic, cancers, cas, nonintrinsic, mutations, studies, incidence, cell, central, human, endogenous, effects, study, nature, due, breast, data, lung, prevention, mutation, rates, smoking, prospective, dna, evidence, mutational, cells, contribution, development, signatures, ageing, environmental, height, replication, burden, model, estimates, exogenous, errors, recent, stem, inflammation, exposure,

Topics {✒️}

nature portfolio privacy policy advertising regional maximum east asia long-lasting nature tools reprints japan stem-cell-model based minimum6 fundamental nature biologic nature suppressing pro-inflammatory mediators cancer research uk smoking-induced genome-wide methylation cancer research vol social media large-scale sequencing data nature nature 529 nature 305 nature 500 nature 469 nature 463 nature 454 steroidal anti-inflammatory drugs author correspondence original author permissions open favouring environmental/lifestyle risks retrospective case-control studies carcinogen-specific signatures demonstrate endogenous anti-cancer processes data-driven analytical approaches telomeres mendelian randomization healthcare research biobehavioral research research focus age-dependent hazard rate complex gene × gene interactions individual-based pooled analysis radiation-induced breast cancer age-adjusted incidence rates malignant cell persistence γ-human papillomavirus types intrinsic cancer-causing factors tissue-specific stem cells historical case-control study strong epidemiology support

Questions {❓}

• Are two mutations sufficient to cause cancer?
• One can see that by ignoring the unknown non-intrinsic risk (area marked with?
• Prostate cancer: is it time to expand the research focus to early-life exposures?

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