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Title[redir]:
The effects of flavonoid baicalein on miRNA expressions in cancer: a systematic review | Naunyn-Schmiedeberg's Archives of Pharmacology
Description:
Baicalein from Scutellaria baicalensis influences miRNA expression in various cancers, affecting key signaling pathways (PI3K/AKT, Wnt/β-catenin, mTOR) and processes like tumor growth, apoptosis, and metastasis. miRNAs, as small non-coding RNAs, play crucial roles in the cancer pathogenesis-associated gene regulations. This study is aimed at systematically reviewing the effects of baicalein on miRNA expression in various cancers. A comprehensive systematic review was conducted following PRISMA guidelines to investigate the impact of baicalein on miRNA expression in cancer. Databases including PubMed, Scopus, and Web of Science were systematically searched using key search terms. Inclusion criteria encompassed studies reporting changes in miRNA expression following baicalein treatment in cancer cell lines and animal models. Data extraction and risk of bias assessment based on SYRCLE’s risk of bias tool were performed to ensure methodological rigor and reliability of the findings. Fifteen studies meeting the inclusion criteria were included in the systematic review. Baicalein impacts miRNA expression in cancers like hepatocellular carcinoma, breast, cervical, ovarian, and gastric cancers, suggesting its potential as a multi-cancer therapeutic. Baicalein regulates tumor-related genes (HDAC10, MDM2, Bcl-2/Bax, and Cyclin E1) and signaling molecules (AKT, FOXO3α), affecting cell viability, apoptosis, and cell cycle, indicating targeted therapeutic potential. In vitro and in vivo studies show baicalein inhibits tumor growth, enhances apoptosis, and regulates cell proliferation, supporting its anticancer effects. Baicalein exhibits potential in modulating miRNA expression in cancer, offering avenues for therapeutic intervention. However, methodological rigor in future studies is essential to enhance the reliability and validity of findings. Comprehensive understanding of baicalein’s effects on miRNA expression holds promise for developing novel cancer treatment strategies.
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Keywords {🔍}
pubmed, article, google, scholar, cas, cancer, central, baicalein, cell, wang, signaling, cells, pathway, expression, res, zhang, protein, sci, med, mol, chen, effects, cervical, therapeutic, khan, zhao, liu, mirna, cancers, targeting, review, apoptosis, anticancer, yang, biol, data, bagheri, tumor, growth, carcinoma, breast, subramaniyan, int, zhu, systematic, inhibits, access, ther, clin, front,
Topics {✒️}
tgf-β/lncrna-malat1/mir-200c signaling pathway regulating mir-3127-5p/fzd4/wnt/β-catenin signaling wnt/beta-catenin/tcf signaling induces regulating mir-150-5p/zbtb4 axis wnt/β-catenin pathway circhiat1/mir-19a-3p axis pi3k/akt/mtor signaling regulates month download article/chapter targeting pten/pi3k/akt pathway wnt/β-catenin egfr/erk/ap-1 pathway natural anti-cancer compound jak2/stat3 signaling pathway pi3k/akt signaling cascade jak/stat signal pathway downstream pi3k/akt pathway blocking akt/mtor pathway interleukin-17 activates jak2/stat3 ferm-enhanced p53 degradation streptozotocin-induced diabetic rats microrna-301b-3p accelerates suppressing pd-l1 expression regulating mir-206/rap1b pathway janus kinase-signal transducer inhibiting pi3k/akt pathway aging-related vascular diseases single-stranded cleavage site anti-breast cancer molecule wnt signaling pathway virus/host cell crosstalk compartment-specific target proteins databases including pubmed article naunyn-schmiedeberg' immunogenetics research center seyed mostafa rahimi systems biology approaches computational proteome-wide study estrogen receptor-alpha frizzled linker domain full article pdf tumor protein d52 article khandan mir-196b-5p anti-tumor immunity khazeei tabari ma regulates cell proliferation baicalein induces apoptosis privacy choices/manage cookies akt/pkb signaling critical signaling pathways
Questions {❓}
- Macedo F, Ladeira K, Longatto-Filho A, Martins SF (2017) Gastric cancer and angiogenesis: is VEGF a useful biomarker to assess progression and remission?
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headline:The effects of flavonoid baicalein on miRNA expressions in cancer: a systematic review
description:Baicalein from Scutellaria baicalensis influences miRNA expression in various cancers, affecting key signaling pathways (PI3K/AKT, Wnt/β-catenin, mTOR) and processes like tumor growth, apoptosis, and metastasis. miRNAs, as small non-coding RNAs, play crucial roles in the cancer pathogenesis-associated gene regulations. This study is aimed at systematically reviewing the effects of baicalein on miRNA expression in various cancers. A comprehensive systematic review was conducted following PRISMA guidelines to investigate the impact of baicalein on miRNA expression in cancer. Databases including PubMed, Scopus, and Web of Science were systematically searched using key search terms. Inclusion criteria encompassed studies reporting changes in miRNA expression following baicalein treatment in cancer cell lines and animal models. Data extraction and risk of bias assessment based on SYRCLE’s risk of bias tool were performed to ensure methodological rigor and reliability of the findings. Fifteen studies meeting the inclusion criteria were included in the systematic review. Baicalein impacts miRNA expression in cancers like hepatocellular carcinoma, breast, cervical, ovarian, and gastric cancers, suggesting its potential as a multi-cancer therapeutic. Baicalein regulates tumor-related genes (HDAC10, MDM2, Bcl-2/Bax, and Cyclin E1) and signaling molecules (AKT, FOXO3α), affecting cell viability, apoptosis, and cell cycle, indicating targeted therapeutic potential. In vitro and in vivo studies show baicalein inhibits tumor growth, enhances apoptosis, and regulates cell proliferation, supporting its anticancer effects. Baicalein exhibits potential in modulating miRNA expression in cancer, offering avenues for therapeutic intervention. However, methodological rigor in future studies is essential to enhance the reliability and validity of findings. Comprehensive understanding of baicalein’s effects on miRNA expression holds promise for developing novel cancer treatment strategies.
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