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Title[redir]:
Exploring the anticancer potential of green synthesized Zn/Cu nanocomposites from olive leaves against lung cancer | Hereditas | Full Text
Description:
Lung cancer remains one of the leading causes of cancer-related death worldwide, with a significant number of patients succumbing to the disease each year. Olea europaea, commonly known as the olive tree, offers a range of health benefits due to its rich content of antioxidants. In the present study, we have reported the green synthesis of a bimetallic nanocomposite of zinc and copper using the leaf extract of Olea europaea (Zn/Cu NCs@ Olea europaea). The nanoparticles were characterized using common chemical techniques. The antioxidant activity of Zn/Cu NCs@ Olea europaea was evaluated using the DPPH assay. The cytotoxicity and anti-lung cancer activity of Zn/Cu NCs@ Olea europaea were investigated using the MTT assay. The results of XRD analysis and FE-SEM imaging showed a crystalline structure for Zn/Cu NCs@ Olea europaea with a semi-spherical morphology and an average size of 49.37 nm. Zn/Cu NCs@ Olea europaea scavenged the free radical DPPH with an IC50 of 363.42 ± 5.02 µg/mL. Furthermore, Zn/Cu NCs@ Olea europaea exhibited acceptable anti-lung cancer activity by preventing growth in the cell lines SK-MES-1, A-549, and LK-2 with IC50 of 154.00 ± 1.83, 228.83 ± 10.59, and 250.55 ± 8.04 µg/mL respectively. The NPs were inactive against the normal cell lines of HUVEC even at high concentrations. The results of the study indicate that Zn/Cu NCs@ Olea europaea, which is green synthesized with a sufficient nano size, can be considered a potent anti-lung cancer agent.
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Keywords {🔍}
cancer, olea, europaea, zncu, article, google, scholar, ncs, lung, nanoparticles, pubmed, cas, activity, cell, antioxidant, treatment, properties, synthesis, bimetallic, olive, central, cells, green, size, fig, results, potential, extract, µgml, nanocomposites, leaves, nanocomposite, cytotoxicity, antilung, lines, nps, applications, anticancer, health, study, metallic, review, chem, analysis, sun, significant, assay, nanotechnology, materials, human,
Topics {✒️}
ni/zn bi-metallic nanocomposite exerts anti-tumor effects zn/cu ncs rsc zn/cu nps synthesized anti-lung cancer activity dose-dependent activity fe-sem imaging showed zn/cu ncs zn/cu bimetallic nps copper-zinc oxide nanocomposite cancer-related death worldwide hplc–esi-tof–ms cell lines sk-mes-1 small-cell lung cancer small-cell lung cancer } \mathord{\left/{\vphantom {{\left strong anti-proliferative effect anti-breast cancer properties possess anti-cancer properties anti-esophageal carcinoma properties successful anti-smoking campaign scratch/abrasion-resistant materials king saud university-science olea europaea extract anti-inflammatory activities present ag–fe bimetallic nanoparticles account hereditas home addressing chemotherapy-induced disabilities olea europaea leaves zn/cu nps privacy choices/manage cookies normal cell line normal cell lines olea europaea collected anti-breast cancer green-synthesized metallic nanoparticles anti-lung cancer palladium-based bimetallic nanoparticles huvec cell lines qingdao central hospital uv-vis spectroscopy fe-sem imaging bmc zinc/copper nanocomposites [41] zinc/copper nanocomposites exhibit antioxidant effects squamous cell carcinoma pdf card olive tree-derived products fe-sem techniques
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headline:Exploring the anticancer potential of green synthesized Zn/Cu nanocomposites from olive leaves against lung cancer
description:Lung cancer remains one of the leading causes of cancer-related death worldwide, with a significant number of patients succumbing to the disease each year. Olea europaea, commonly known as the olive tree, offers a range of health benefits due to its rich content of antioxidants. In the present study, we have reported the green synthesis of a bimetallic nanocomposite of zinc and copper using the leaf extract of Olea europaea (Zn/Cu NCs@ Olea europaea). The nanoparticles were characterized using common chemical techniques. The antioxidant activity of Zn/Cu NCs@ Olea europaea was evaluated using the DPPH assay. The cytotoxicity and anti-lung cancer activity of Zn/Cu NCs@ Olea europaea were investigated using the MTT assay. The results of XRD analysis and FE-SEM imaging showed a crystalline structure for Zn/Cu NCs@ Olea europaea with a semi-spherical morphology and an average size of 49.37 nm. Zn/Cu NCs@ Olea europaea scavenged the free radical DPPH with an IC50 of 363.42 ± 5.02 µg/mL. Furthermore, Zn/Cu NCs@ Olea europaea exhibited acceptable anti-lung cancer activity by preventing growth in the cell lines SK-MES-1, A-549, and LK-2 with IC50 of 154.00 ± 1.83, 228.83 ± 10.59, and 250.55 ± 8.04 µg/mL respectively. The NPs were inactive against the normal cell lines of HUVEC even at high concentrations. The results of the study indicate that Zn/Cu NCs@ Olea europaea, which is green synthesized with a sufficient nano size, can be considered a potent anti-lung cancer agent.
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headline:Exploring the anticancer potential of green synthesized Zn/Cu nanocomposites from olive leaves against lung cancer
description:Lung cancer remains one of the leading causes of cancer-related death worldwide, with a significant number of patients succumbing to the disease each year. Olea europaea, commonly known as the olive tree, offers a range of health benefits due to its rich content of antioxidants. In the present study, we have reported the green synthesis of a bimetallic nanocomposite of zinc and copper using the leaf extract of Olea europaea (Zn/Cu NCs@ Olea europaea). The nanoparticles were characterized using common chemical techniques. The antioxidant activity of Zn/Cu NCs@ Olea europaea was evaluated using the DPPH assay. The cytotoxicity and anti-lung cancer activity of Zn/Cu NCs@ Olea europaea were investigated using the MTT assay. The results of XRD analysis and FE-SEM imaging showed a crystalline structure for Zn/Cu NCs@ Olea europaea with a semi-spherical morphology and an average size of 49.37 nm. Zn/Cu NCs@ Olea europaea scavenged the free radical DPPH with an IC50 of 363.42 ± 5.02 µg/mL. Furthermore, Zn/Cu NCs@ Olea europaea exhibited acceptable anti-lung cancer activity by preventing growth in the cell lines SK-MES-1, A-549, and LK-2 with IC50 of 154.00 ± 1.83, 228.83 ± 10.59, and 250.55 ± 8.04 µg/mL respectively. The NPs were inactive against the normal cell lines of HUVEC even at high concentrations. The results of the study indicate that Zn/Cu NCs@ Olea europaea, which is green synthesized with a sufficient nano size, can be considered a potent anti-lung cancer agent.
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