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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s10555-023-10126-x.

Title:
Resveratrol as sensitizer in colorectal cancer plasticity | Cancer and Metastasis Reviews
Description:
Abstract Despite tremendous medical treatment successes, colorectal cancer (CRC) remains a leading cause of cancer deaths worldwide. Chemotherapy as monotherapy can lead to significant side effects and chemoresistance that can be linked to several resistance-activating biological processes, including an increase in inflammation, cellular plasticity, multidrug resistance (MDR), inhibition of the sentinel gene p53, and apoptosis. As a consequence, tumor cells can escape the effectiveness of chemotherapeutic agents. This underscores the need for cross-target therapeutic approaches that are not only pharmacologically safe but also modulate multiple potent signaling pathways and sensitize cancer cells to overcome resistance to standard drugs. In recent years, scientists have been searching for natural compounds that can be used as chemosensitizers in addition to conventional medications for the synergistic treatment of CRC. Resveratrol, a natural polyphenolic phytoalexin found in various fruits and vegetables such as peanuts, berries, and red grapes, is one of the most effective natural chemopreventive agents. Abundant in vitro and in vivo studies have shown that resveratrol, in interaction with standard drugs, is an effective chemosensitizer for CRC cells to chemotherapeutic agents and thus prevents drug resistance by modulating multiple pathways, including transcription factors, epithelial-to-mesenchymal transition-plasticity, proliferation, metastasis, angiogenesis, cell cycle, and apoptosis. The ability of resveratrol to modify multiple subcellular pathways that may suppress cancer cell plasticity and reversal of chemoresistance are critical parameters for understanding its anti-cancer effects. In this review, we focus on the chemosensitizing properties of resveratrol in CRC and, thus, its potential importance as an additive to ongoing treatments. Graphical abstract
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Science
  • Health & Fitness
  • Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

pubmed, resveratrol, cancer, google, scholar, article, cas, cells, cell, crc, journal, central, resistance, colorectal, signaling, tumor, research, colon, expression, drug, effects, human, pathway, apoptosis, molecular, treatment, factor, clinical, mechanisms, wang, plasticity, activation, zhang, patients, international, pathways, cellular, growth, inhibition, stem, role, medicine, httpsdoiorgs, therapeutic, inflammation, nfκb, effect, metastasis, chemotherapeutic, drugs,

Topics {✒️}

tnf-α/nf-kb/inos/hif-1α axis-mediated fibrosis nuclear factor kappa-light-chain-enhancer il-1beta-induced nf-kappab-mediated inflammation regulating tlr4/syk/nf-κb signals tgf-β1/smads signaling pathway samson mathews samuel β1-integrin/hif-1α axis c-jun nh2-terminal kinase b-cell lymphoma extra-large pi3k/akt/nf-κb signaling pathway inhibits hypoxia-induced hif-1α inhibiting stat3/hif-1α/vegf pathway suppressing tlr4/nf-κb/stat3 activation copper-transporting p-type atpase interleukin-1β-induced chondrocytes injury inhibiting hif-1α/nlrp3 pathway s-phase cell-cycle arrest lipopolysaccharide-induced nf-κb activation il-1β-induced chondrocyte damage wnt/β-catenin signaling pathway altered cytokine profile grow human-monocyte-derived macrophages altered amino acid/protein/lipid regulating wnt/β-catenin signaling transcription factor nf-kappa sirt-1/nf-κb signaling pathway anti-inflammatory t-cell response sirt1-nf-κb signaling pathway /ampk/nf-kb pathway nf-κb-promoted end-proteins nuclear transcription factor-kappab inducing s-phase arrest inhibiting tlr4/hif-1α gly-ldl-induced huvecs titanium particle-induced osteolysis pyrene-induced colon polyps thioacetamide-induced liver injury pten-pi3k-akt axis tgf-beta increases induced wnt/β-catenin pathway cytokine-induced signaling pathways pro-apoptotic bax gene ameliorating p-glycoprotein activity pro-inflammatory-related activations basal pathogen-responsive sequence nf-κb inhibitor alpha downregulating hif-1α expression view keywords ‘cancer nf-κb signaling pathway

Questions {❓}

  • Are the cardioprotective effects of the phytoestrogen resveratrol sex-dependent?
  • Improving outcomes in colorectal cancer: Where do we go from here?
  • Oxidative stress, inflammation, and cancer: how are they linked?
  • Resveratrol supplementation: Where are we now and where should we go?
  • Resveratrol: A molecule whose time has come?
  • The legitimate inferential question is: Why has resveratrol been detected in many natural products?
  • What is new for an old molecule?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Resveratrol as sensitizer in colorectal cancer plasticity
         description:Despite tremendous medical treatment successes, colorectal cancer (CRC) remains a leading cause of cancer deaths worldwide. Chemotherapy as monotherapy can lead to significant side effects and chemoresistance that can be linked to several resistance-activating biological processes, including an increase in inflammation, cellular plasticity, multidrug resistance (MDR), inhibition of the sentinel gene p53, and apoptosis. As a consequence, tumor cells can escape the effectiveness of chemotherapeutic agents. This underscores the need for cross-target therapeutic approaches that are not only pharmacologically safe but also modulate multiple potent signaling pathways and sensitize cancer cells to overcome resistance to standard drugs. In recent years, scientists have been searching for natural compounds that can be used as chemosensitizers in addition to conventional medications for the synergistic treatment of CRC. Resveratrol, a natural polyphenolic phytoalexin found in various fruits and vegetables such as peanuts, berries, and red grapes, is one of the most effective natural chemopreventive agents. Abundant in vitro and in vivo studies have shown that resveratrol, in interaction with standard drugs, is an effective chemosensitizer for CRC cells to chemotherapeutic agents and thus prevents drug resistance by modulating multiple pathways, including transcription factors, epithelial-to-mesenchymal transition-plasticity, proliferation, metastasis, angiogenesis, cell cycle, and apoptosis. The ability of resveratrol to modify multiple subcellular pathways that may suppress cancer cell plasticity and reversal of chemoresistance are critical parameters for understanding its anti-cancer effects. In this review, we focus on the chemosensitizing properties of resveratrol in CRC and, thus, its potential importance as an additive to ongoing treatments.
         datePublished:2023-07-29T00:00:00Z
         dateModified:2023-07-29T00:00:00Z
         pageStart:55
         pageEnd:85
         license:http://creativecommons.org/licenses/by/4.0/
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         keywords:
            Colorectal cancer
            Chemoresistance
            Chemosensitization
            Multidrug resistance
            Resveratrol
            Cancer cell plasticity
            Cancer Research
            Oncology
            Biomedicine
            general
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                     name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
                     address:
                        name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Munich, Germany
                        type:PostalAddress
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                     name:Comenius University in Bratislava
                     address:
                        name:Clinic of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
                        type:PostalAddress
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               type:Person
               name:Samson Mathews Samuel
               url:https://orcid.org/0000-0002-5541-6623
               affiliation:
                     name:Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation
                     address:
                        name:Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation, Doha, Qatar
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Peter Kubatka
               url:https://orcid.org/0000-0003-4312-5076
               affiliation:
                     name:Comenius University in Bratislava
                     address:
                        name:Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
                        type:PostalAddress
                     type:Organization
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               name:Dietrich Büsselberg
               url:https://orcid.org/0000-0001-5196-3366
               affiliation:
                     name:Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation
                     address:
                        name:Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation, Doha, Qatar
                        type:PostalAddress
                     type:Organization
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               name:Ajaikumar B. Kunnumakkara
               url:https://orcid.org/0000-0001-9121-6816
               affiliation:
                     name:Indian Institute of Technology (IIT) Guwahati
                     address:
                        name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mehdi Shakibaei
               url:https://orcid.org/0000-0002-6304-7506
               affiliation:
                     name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
                     address:
                        name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Munich, Germany
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ScholarlyArticle:
      headline:Resveratrol as sensitizer in colorectal cancer plasticity
      description:Despite tremendous medical treatment successes, colorectal cancer (CRC) remains a leading cause of cancer deaths worldwide. Chemotherapy as monotherapy can lead to significant side effects and chemoresistance that can be linked to several resistance-activating biological processes, including an increase in inflammation, cellular plasticity, multidrug resistance (MDR), inhibition of the sentinel gene p53, and apoptosis. As a consequence, tumor cells can escape the effectiveness of chemotherapeutic agents. This underscores the need for cross-target therapeutic approaches that are not only pharmacologically safe but also modulate multiple potent signaling pathways and sensitize cancer cells to overcome resistance to standard drugs. In recent years, scientists have been searching for natural compounds that can be used as chemosensitizers in addition to conventional medications for the synergistic treatment of CRC. Resveratrol, a natural polyphenolic phytoalexin found in various fruits and vegetables such as peanuts, berries, and red grapes, is one of the most effective natural chemopreventive agents. Abundant in vitro and in vivo studies have shown that resveratrol, in interaction with standard drugs, is an effective chemosensitizer for CRC cells to chemotherapeutic agents and thus prevents drug resistance by modulating multiple pathways, including transcription factors, epithelial-to-mesenchymal transition-plasticity, proliferation, metastasis, angiogenesis, cell cycle, and apoptosis. The ability of resveratrol to modify multiple subcellular pathways that may suppress cancer cell plasticity and reversal of chemoresistance are critical parameters for understanding its anti-cancer effects. In this review, we focus on the chemosensitizing properties of resveratrol in CRC and, thus, its potential importance as an additive to ongoing treatments.
      datePublished:2023-07-29T00:00:00Z
      dateModified:2023-07-29T00:00:00Z
      pageStart:55
      pageEnd:85
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s10555-023-10126-x
      keywords:
         Colorectal cancer
         Chemoresistance
         Chemosensitization
         Multidrug resistance
         Resveratrol
         Cancer cell plasticity
         Cancer Research
         Oncology
         Biomedicine
         general
      image:
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         name:Cancer and Metastasis Reviews
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            1573-7233
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      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Aranka Brockmueller
            url:https://orcid.org/0000-0001-8101-2828
            affiliation:
                  name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
                  address:
                     name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anjana Sajeev
            affiliation:
                  name:Indian Institute of Technology (IIT) Guwahati
                  address:
                     name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lenka Koklesova
            url:http://orcid.org/0009-0000-2732-066X
            affiliation:
                  name:Comenius University in Bratislava
                  address:
                     name:Clinic of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Samson Mathews Samuel
            url:https://orcid.org/0000-0002-5541-6623
            affiliation:
                  name:Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation
                  address:
                     name:Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation, Doha, Qatar
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Peter Kubatka
            url:https://orcid.org/0000-0003-4312-5076
            affiliation:
                  name:Comenius University in Bratislava
                  address:
                     name:Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dietrich Büsselberg
            url:https://orcid.org/0000-0001-5196-3366
            affiliation:
                  name:Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation
                  address:
                     name:Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation, Doha, Qatar
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ajaikumar B. Kunnumakkara
            url:https://orcid.org/0000-0001-9121-6816
            affiliation:
                  name:Indian Institute of Technology (IIT) Guwahati
                  address:
                     name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mehdi Shakibaei
            url:https://orcid.org/0000-0002-6304-7506
            affiliation:
                  name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
                  address:
                     name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Cancer and Metastasis Reviews
      issn:
         1573-7233
         0167-7659
      volumeNumber:43
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      name:Springer US
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      name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
      address:
         name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Munich, Germany
         type:PostalAddress
      name:Indian Institute of Technology (IIT) Guwahati
      address:
         name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, India
         type:PostalAddress
      name:Comenius University in Bratislava
      address:
         name:Clinic of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
         type:PostalAddress
      name:Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation
      address:
         name:Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation, Doha, Qatar
         type:PostalAddress
      name:Comenius University in Bratislava
      address:
         name:Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
         type:PostalAddress
      name:Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation
      address:
         name:Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation, Doha, Qatar
         type:PostalAddress
      name:Indian Institute of Technology (IIT) Guwahati
      address:
         name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, India
         type:PostalAddress
      name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
      address:
         name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Munich, Germany
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Aranka Brockmueller
      url:https://orcid.org/0000-0001-8101-2828
      affiliation:
            name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
            address:
               name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Munich, Germany
               type:PostalAddress
            type:Organization
      name:Anjana Sajeev
      affiliation:
            name:Indian Institute of Technology (IIT) Guwahati
            address:
               name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, India
               type:PostalAddress
            type:Organization
      name:Lenka Koklesova
      url:http://orcid.org/0009-0000-2732-066X
      affiliation:
            name:Comenius University in Bratislava
            address:
               name:Clinic of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
               type:PostalAddress
            type:Organization
      name:Samson Mathews Samuel
      url:https://orcid.org/0000-0002-5541-6623
      affiliation:
            name:Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation
            address:
               name:Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation, Doha, Qatar
               type:PostalAddress
            type:Organization
      name:Peter Kubatka
      url:https://orcid.org/0000-0003-4312-5076
      affiliation:
            name:Comenius University in Bratislava
            address:
               name:Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
               type:PostalAddress
            type:Organization
      name:Dietrich Büsselberg
      url:https://orcid.org/0000-0001-5196-3366
      affiliation:
            name:Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation
            address:
               name:Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation, Doha, Qatar
               type:PostalAddress
            type:Organization
      name:Ajaikumar B. Kunnumakkara
      url:https://orcid.org/0000-0001-9121-6816
      affiliation:
            name:Indian Institute of Technology (IIT) Guwahati
            address:
               name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, India
               type:PostalAddress
            type:Organization
      name:Mehdi Shakibaei
      url:https://orcid.org/0000-0002-6304-7506
      affiliation:
            name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
            address:
               name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Munich, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Munich, Germany
      name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, India
      name:Clinic of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
      name:Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation, Doha, Qatar
      name:Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
      name:Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar (Medbay), Education City, Qatar Foundation, Doha, Qatar
      name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, India
      name:Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Munich, Germany

External Links {🔗}(1268)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Pace
  • Particles.js
  • Prism.js

CDN Services {📦}

  • Crossref

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