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We are analyzing https://www.nature.com/articles/s43018-020-0026-6.

Title:
Imaging mass cytometry and multiplatform genomics define the phenogenomic landscape of breast cancer | Nature Cancer
Description:
Genomic alterations shape cell phenotypes and the structure of tumor ecosystems in poorly defined ways. To investigate these relationships, we used imaging mass cytometry to quantify the expression of 37 proteins with subcellular spatial resolution in 483 tumors from the METABRIC cohort. Single-cell analysis revealed cell phenotypes spanning epithelial, stromal and immune types. Distinct combinations of cell phenotypes and cell–cell interactions were associated with genomic subtypes of breast cancer. Epithelial luminal cell phenotypes separated into those predominantly impacted by mutations and those affected by copy number aberrations. Several features of tumor ecosystems, including cellular neighborhoods, were linked to prognosis, illustrating their clinical relevance. In summary, systematic analysis of single-cell phenotypic and spatial correlates of genomic alterations in cancer revealed how genomes shape both the composition and architecture of breast tumor ecosystems and will enable greater understanding of the phenotypic impact of genomic alterations. Bodenmiller and colleagues pair imaging mass cytometry with data from the METABRIC cohort to define single-cell phenotypic and genomic features of breast cancer with spatial context, finding associations with breast cancer subtypes and prognosis.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Telecommunications

Content Management System {📝}

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Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,197,185 visitors per month in the current month.

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How Does Nature.com Make Money? {💸}


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The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

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How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$531,700 per month
According to our algorithms, Nature.com's monthly online income from display advertising ranges from $354,498 to $974,870.

Keywords {🔍}

pubmed, article, cancer, cell, google, scholar, breast, cas, nature, data, central, cambridge, phenotypes, genomic, expression, molecular, university, nat, cells, analysis, fig, cytometry, ali, access, tumours, research, extended, imaging, institute, caldas, subtypes, department, phenotype, content, mass, types, authors, human, tumour, associations, linear, columbia, represent, enrichment, raza, cruk, bodenmiller, tumor, spatial, clinical,

Topics {✒️}

nature portfolio journals privacy policy nature portfolio received research grants advertising social media european research council language reprints cancer research uk gene-expression-based retrospective study suet-feung chin processed single-cell data data-driven phenotypic dissection illumina bead-based data cancer research structured tumor-immune microenvironment publishing agreement pan-tumor genomic biomarkers single-linkage hierarchical clustering high-throughput molecular profiling cd8+ t-cell infiltration calculating exact p-values european genome–phenome archive hypoxia-mediated immune escape nature+ nature nature 406 nature 486 nature 534 nature 497 nature 567 nature 475 nature 481 sided kruskal-wallis tests accepted manuscript version permissions genome-driven integrated classification spatial genomics maps springerlink instant access single-cell phenotypic research curated clinical data cell-cell interactions identified phenograph-assigned cell types luminal breast cancer cell-cell interaction enrichment single-cell atlas conducted data analysis processed genomic data

Schema {🗺️}

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      email:[email protected]
      name:Bernd Bodenmiller
      url:http://orcid.org/0000-0002-6325-7861
      affiliation:
            name:University of Zurich
            address:
               name:Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland
      name:CRUK Cambridge Institute, University of Cambridge, Cambridge, UK
      name:Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland
      name:Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland
      name:Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland
      name:Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland
      name:CRUK Cambridge Institute, University of Cambridge, Cambridge, UK
      name:Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge, UK
      name:CRUK Cambridge Institute, University of Cambridge, Cambridge, UK
      name:CRUK Cambridge Institute, University of Cambridge, Cambridge, UK
      name:Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, Canada
      name:CRUK Cambridge Institute, University of Cambridge, Cambridge, UK
      name:Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge, UK
      name:Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland
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