
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Genome-driven integrated classification of breast cancer validated in over 7,500 samples - PMC
Description:
IntClust is a classification of breast cancer comprising 10 subtypes based on molecular drivers identified through the integration of genomic and transcriptomic data from 1,000 breast tumors and validated in a further 1,000. We present a reliable ...
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Keywords {🔍}
intclust, cancer, breast, doi, expression, gene, subtypes, study, data, classification, subtype, studies, genes, additional, file, metabric, google, scholar, pubmed, samples, tumors, survival, pam, number, copy, based, pmc, clinical, classifier, models, article, scmgene, external, cell, genomic, tumor, free, molecular, analysis, nature, method, dataset, tcga, explained, comparison, lines, patterns, profiles, figure, patients,
Topics {✒️}
estrogen receptor 95% confidence interval receiver-operating-characteristic curves 11q13/14 locus unique geo identifier distant metastasis-free survival org/web/packages/boot/index receiver operating characteristic curve genome-wide driver-based classification selective growth advantage european genome-phenome archive genome-driven integrated classification er-/her2- subtype kaplan-meier survival plots copy number-driven genes long-term clinical management long-term clinical benefit human breast tumours er-negative breast cancer pmc beta search high-resolution copy-number subtype cna profiles receive neo-adjuvant chemotherapy mutations deemed ‘m-class pathological complete response adjusted r-squared statistic er-positive breast cancer growth advantage data-driven approaches designed er+/her2 studies received neo-adjuvant adjusted r-squared statistics average gene-expression profiles relapse-free survival copy number-based classifier geo driver-based molecular taxonomy r-squared values explained pathologic complete response node-negative breast cancer gene expression-based classifier subgroups comprise high-risk human cancers org/web/packages/] 41 cross-platform normalization methods copy number profiles copy-number profiles expression-based intclust classification uk/ega/studies/egas00000000083]
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