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Title[redir]:
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups - PMC
Description:
The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We present an integrated analysis of copy number and gene expression in a ...
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Keywords {🔍}
cancer, supplementary, doi, breast, expression, fig, subgroup, number, pubmed, google, scholar, subgroups, pmc, copy, genes, article, cnas, cambridge, gene, cancers, integrative, intclust, genomic, landscape, data, loci, cell, tumours, set, cases, research, free, cis, tables, methods, molecular, analysis, validation, trans, university, nature, patients, profiles, figs, associations, nihmssupplementzip, zip, principal, investigator, discovery,
Topics {✒️}
cytotoxic t-lymphocyte-mediated apoptosis 17q23/20q cis-acting luminal key cell-cycle-related genes expression outliers refine european genome-phenome archive 16p gain/16q loss trans-acting aberration hotspots dual specificity kinase trans-acting deletion hotspots cambridge research institute anne-lise børresen-dale 6 long-term clinical follow strong cis-acting associations population-based molecular subgrouping characteristic cis-acting alterations nci-pid curated pathways good long-term outcomes 11q13/14 cis-acting subgroup pseudo-anonymized clinical data pmc beta search basal-specific trans module tumour expression architecture pp2a holoenzyme complex worst disease-specific survival trans-acting loci modulated gene basis genome-wide high-genomic instability subgroup tumour-infiltrating lymphocytes cis-acting cnas dominated integrated genomic/transcriptomic analysis cancer research uk immune response modules adaptive immune response gene expression variation breast cancer population distinct clinical outcomes significant predictor–expression associations high-risk 11q13/14 subgroup erbb2-amplified cancers composed mitotic er-positive cancers trans expression modules putative driver aberrations 2cancer research uk clinically relevant groupings er-positive subgroup composed copy number gain multiple genomic views predominantly er-positive cancers breast cancer genome multiple cancer types
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