
NCBI . NLM . NIH . GOV {
}
Title[redir]:
A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry - PMC
Description:
Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β cells. A comprehensive picture of the changes during T1D development is lacking due to limited sample availability, inability to sample longitudinally, and the ...
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Keywords {🔍}
cell, cells, islet, islets, figure, donors, immune, doi, data, google, scholar, pubmed, analysis, pseudostage, pancreas, type, pmc, rridab, imc, article, interactions, diabetes, free, tissue, human, disease, progression, imaging, pseudotime, markers, monoclonal, types, expression, performed, number, cat, recentonset, mass, antibodies, pancreatic, image, images, multiplexed, antibody, rabbit, fraction, measured, information, sections, composition,
Topics {✒️}
receptor-type tyrosine-protein phosphatase recent-onset versus long-duration smooth muscle actin long-standing childhood-onset diabetes rabbit polyclonal anti-iapp pmc beta search io/monocle-release/docs org/web/packages/tsne open rabbit anti-glucagon-156gd rabbit anti-synaptophysin-160gd carbonic anhydrase ix samples collected post-mortem epitope-targeted mass spectrometry single-cell molecular profiling paraffin-embedded cancer tissue org/web/packages/tsne detailed marker-based timeline long-duration t1d tended cell-cell interactions evolve cell-cell interactions change long-standing t1d architecture supervised machine-learning approaches extract single-cell information long-standing t1d duration β cell-specific markers recent-onset t1d retained goat anti-pdx1 phospho-histone h3 represent recent-onset t1d islet-specific autoreactive cd8+ etoc blurb poly [adp-ribose] polymerase β cell-rich islets autoantibody-positive donors prior insulin-producing β cells large-scale neighborhood analysis e-/p-cadherin γ cell-rich islets metal-labeled primary antibodies metal-tagged antibodies cell-cell interactions revealed mouse splenic architecture recent-onset t1d retain increasing bin numbers rodriguez-calvo malaisse-lagae van der maaten includes peri-endothelial cells /bodenmillergroup/histocat/releases ilastik 1 full antibody panel
Questions {❓}
- Are They the Architectural Cornerstones of Islet Structure and Co-ordination?
- Indirect evidence for islet regeneration?
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