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We are analyzing https://www.nature.com/articles/s41580-019-0123-5.

Title:
Metabolic regulation of cell growth and proliferation | Nature Reviews Molecular Cell Biology
Description:
Cellular metabolism is at the foundation of all biological activities. The catabolic processes that support cellular bioenergetics and survival have been well studied. By contrast, how cells alter their metabolism to support anabolic biomass accumulation is less well understood. During the commitment to cell proliferation, extensive metabolic rewiring must occur in order for cells to acquire sufficient nutrients such as glucose, amino acids, lipids and nucleotides, which are necessary to support cell growth and to deal with the redox challenges that arise from the increased metabolic activity associated with anabolic processes. Defining the mechanisms of this metabolic adaptation for cell growth and proliferation is now a major focus of research. Understanding the principles that guide anabolic metabolism may ultimately enhance ways to treat diseases that involve deregulated cell growth and proliferation, such as cancer. Cellular metabolism is rewired in proliferating cells to support their increased need for macromolecule biosynthesis. A better understanding of how cells utilize nutrients for biosynthetic pathways and how they overcome the metabolic challenges associated with high proliferation rates can lead to better control of cell proliferation and improved cancer treatments.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {πŸ“š}

  • Education
  • Science
  • Telecommunications

Content Management System {πŸ“}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {πŸ“ˆ}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Nature.com Make Money? {πŸ’Έ}


Display Ads {🎯}


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Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {πŸ’°}


Display Ads {🎯}

$63,100 per month
Estimations show Nature.com's display ad online revenue falls between $42,042 and $115,616 per month.

Keywords {πŸ”}

pubmed, article, google, scholar, cas, central, cell, cancer, nature, metabolism, cells, biol, nat, growth, acid, metabolic, synthesis, amino, pathway, protein, science, rev, regulation, cellular, mol, stress, thompson, human, nutrient, fatty, proliferation, access, tumor, autophagy, signaling, chem, response, mtorc, res, mitochondrial, function, support, survival, glucose, regulates, gene, serine, pancreatic, content, acids,

Topics {βœ’οΈ}

permissions reprints privacy policy nature portfolio journals research promote cancer development regional glutamine deficiency 18f-fdg pet/ct imaging scientific advisory board positron-emission-tomography-based imaging nature portfolio advertising open reading frames social media her2-positive breast cancer author information authors cystine/glutamate transporter gene carboxy-terminal activation domain author correspondence arginine/lysine transporter cat-1 /ebp-atf response element open-label nutrient limited conditions aminoacyl-trna synthetase genes serine/threonine kinase akt1 akt-directed glucose metabolism personal data fatty acid uptake phosphoinositide 3-kinase/akt pathway p53-dependent metabolic remodelling data protection suppresses mtor signalling nutrient-sensing response pathway peer review permissions growth factor signalling targeting metastasis-initiating cells springerlink instant access mitochondrial complex iii functional genomics reveal mtorc1-mediated protein translation pancreatic stellate cells phosphatidylinositol-3 kinase/akt regulation pancreatic tumor growth fatty acid synthase starvation-induced ribophagy published maps amino acid starvation amino acid limitation amino acid source maintain glucose uptake

Questions {❓}

  • Making the first move in EGFR-driven or ALK-driven NSCLC: first-generation or next-generation TKI?

Schema {πŸ—ΊοΈ}

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