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NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Questions
  10. Schema
  11. Social Networks
  12. External Links
  13. Analytics And Tracking
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We are analyzing https://www.nature.com/articles/nrc3518.

Title:
Progesterone signalling in breast cancer: a neglected hormone coming into the limelight | Nature Reviews Cancer
Description:
Awareness is increasing that progesterone signalling via the progesterone receptor (PR) has important roles in breast biology and breast cancer. Understanding more about this pathway may lead to new therapeutic and preventive options for breast cancer. Understanding the biology of the breast and how ovarian hormones impinge on it is key to rational new approaches in breast cancer prevention and therapy. Because of the success of selective oestrogen receptor modulators (SERMs), such as tamoxifen, and aromatase inhibitors in breast cancer treatment, oestrogens have long received the most attention. Early progesterone receptor (PR) antagonists, however, were dismissed because of severe side effects, but awareness is now increasing that progesterone is an important hormone in breast cancer. Oestrogen receptor-α (ERα) signalling and PR signalling have distinct roles in normal mammary gland biology in mice; both ERα and PR delegate many of their biological functions to distinct paracrine mediators. If the findings in the mouse model translate to humans, new preventive and therapeutic perspectives might open up.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$63,100 per month
Our estimates place Nature.com's monthly online earnings from display ads at $42,042 to $115,616.

Keywords {🔍}

pubmed, google, scholar, cas, cancer, breast, mammary, progesterone, receptor, nature, gland, central, cells, development, cell, estrogen, mouse, hormone, signalling, therapy, study, expression, epithelial, article, mice, human, women, natl, res, brisken, access, proliferation, molecular, oestrogen, normal, postmenopausal, stem, content, paracrine, biol, sci, endocrinology, rank, cookies, function, steroid, hormonal, proc, risk, replacement,

Topics {✒️}

nature portfolio permissions reprints privacy policy experimental cancer research wnt/β-catenin-responsive stem cells middle-aged women advertising social media open α-smooth muscle actin post-natal mammary development nature rev transforming growth factor-β1 assessing reproductive status/stages author information authors progestin-driven mammary cancer estrogen receptor-α signaling triple-negative breast carcinomas nature 490 nature 486 nature 303 nature 406 nature 397 nature 465 nature 468 nature 479 nature 470 nature hormone-induced mammary tumors ccaat/enhancer binding protein increased epithelial proliferation alveolar epithelial cells competing financial interests springerlink instant access impairs alveolar differentiation permissions estrogen receptor α author apologizes author declares murine mammary gland personal data major regulatory axis oestrogen receptor-α epithelial progesterone receptor negative predictive factor mammary-gland development mammary gland development adult mammary epithelium early progesterone receptor mouse reproductive phenotypes

Questions {❓}

  • Intra-tumour heterogeneity: a looking glass for cancer?

Schema {🗺️}

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         description: Awareness is increasing that progesterone signalling via the progesterone receptor (PR) has important roles in breast biology and breast cancer. Understanding more about this pathway may lead to new therapeutic and preventive options for breast cancer. Understanding the biology of the breast and how ovarian hormones impinge on it is key to rational new approaches in breast cancer prevention and therapy. Because of the success of selective oestrogen receptor modulators (SERMs), such as tamoxifen, and aromatase inhibitors in breast cancer treatment, oestrogens have long received the most attention. Early progesterone receptor (PR) antagonists, however, were dismissed because of severe side effects, but awareness is now increasing that progesterone is an important hormone in breast cancer. Oestrogen receptor-α (ERα) signalling and PR signalling have distinct roles in normal mammary gland biology in mice; both ERα and PR delegate many of their biological functions to distinct paracrine mediators. If the findings in the mouse model translate to humans, new preventive and therapeutic perspectives might open up.
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      headline:Progesterone signalling in breast cancer: a neglected hormone coming into the limelight
      description: Awareness is increasing that progesterone signalling via the progesterone receptor (PR) has important roles in breast biology and breast cancer. Understanding more about this pathway may lead to new therapeutic and preventive options for breast cancer. Understanding the biology of the breast and how ovarian hormones impinge on it is key to rational new approaches in breast cancer prevention and therapy. Because of the success of selective oestrogen receptor modulators (SERMs), such as tamoxifen, and aromatase inhibitors in breast cancer treatment, oestrogens have long received the most attention. Early progesterone receptor (PR) antagonists, however, were dismissed because of severe side effects, but awareness is now increasing that progesterone is an important hormone in breast cancer. Oestrogen receptor-α (ERα) signalling and PR signalling have distinct roles in normal mammary gland biology in mice; both ERα and PR delegate many of their biological functions to distinct paracrine mediators. If the findings in the mouse model translate to humans, new preventive and therapeutic perspectives might open up.
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Social Networks {👍}(2)

External Links {🔗}(234)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
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CDN Services {📦}

  • Crossref

4.17s.