
NCBI . NLM . NIH . GOV {
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Title[redir]:
Fibroblast-recruited, tumor-infiltrating CD4+ T cells stimulate mammary cancer metastasis through RANKL-RANK signaling - PMC
Description:
Inflammatory mechanisms influence tumor development and metastatic progression1. Of interest is the role of such mechanisms in metastatic spread of tumors whose etiology does not involve pre-existing inflammation or infection, such as breast and ...
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Keywords {🔍}
cells, fig, rankl, mice, doi, supplementary, metastasis, tumors, cancer, mammary, breast, tumor, rank, pubmed, google, scholar, pulmonary, expression, cell, sem, mrna, means, pmc, primary, human, foxp, carcinoma, fvbn, rag, article, metastatic, cdcd, nature, multiplicity, mmtverbb, free, expressed, lung, pcam, transplanted, signaling, analyzed, days, tumorinfiltrating, results, metastases, incidence, glands, stroma, nlm,
Topics {✒️}
generated mmtv-erbb2/rank+/−/fvb mice tumor-bearing mmtv-erbb2 mice mmtv-erbb2/rank+/− mice expressed mmtv-erbb2/rank+/+/fvb mice mmtv-erbb2/rank+/−/fvb mice progestin-driven mammary cancer mmtv-erbb2/fvb mice treated tumor necrosis factor mmtv-erbb2 transgenic mice spontaneous mmtv-erbb2 tumors mmtv-erbb2-induced tumors circulating metastasis-initiating cells mmtv-erbb2 mice correlate mmtv-erbb2 specific primers erbb2-induced mammary tumor erbb2-transformed carcinoma cells rank-fc fusion protein mmtv-erbb2/rank+/+ tumors lymph node macro-metastasis mmtv-erbb2/rank+/− mice involve pre-existing inflammation mmtv-erbb2/rank+/+/fvb mmtv-erbb2/rank+/−/fvb pmc beta search erbb2-induced mammary tumors potential anti-tumorigenic activity rank-negative t47d cells tumor-infiltrating cd4+cd25+foxp3+ weekly intra-tumoral injections mmtv-erbb2/fvb mice lymph node-positive tumors mammary/breast cancer metastasis sectioned mmtv-erbb2 tumors tumor-infiltrating treg cells preferentially attracted cd4+cd25+ tumor-free virgins mt2-inoculated rag1−/− mice potent pro-metastatic effect mmtv-erbb2/rank+/+ cell-reconstituted rag1−/− mice tumor-infiltrating cd4+cd25+ mmtv-erbb2 tumor mock-reconstituted rag1−/− mice maspin-mt2 tumors expressed license information pmcid nih asthma research mmtv-erbb2 tumors mmtv-erbb2 mice human breast cancer lymph node development
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