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Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells | Nature Reviews Cancer
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This article introduces some preliminary mathematical models of the basic decision circuits in breast cancer cells, with a view to understanding in greater detail their susceptibility or resistance to endocrine therapy. Cancers of the breast and other tissues arise from aberrant decision-making by cells regarding their survival or death, proliferation or quiescence, damage repair or bypass. These decisions are made by molecular signalling networks that process information from outside and from within the breast cancer cell and initiate responses that determine the cell
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