
NCBI . NLM . NIH . GOV {
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Title[redir]:
Mathematical Modelling of Cell-Fate Decision in Response to Death Receptor Engagement - PMC
Description:
Cytokines such as TNF and FASL can trigger death or survival depending on cell lines and cellular conditions. The mechanistic details of how a cell chooses among these cell fates are still unclear. The understanding of these processes is important ...
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Keywords {🔍}
doi, model, cell, death, google, scholar, apoptosis, pubmed, tnf, nfκb, necrosis, activation, survival, casp, figure, states, pathway, rip, stable, pathways, mpt, mutant, ciap, caspase, pdf, fate, data, fadd, state, type, decision, cells, deletion, pmc, cancer, reduced, fas, logical, analysis, master, cellular, components, biol, article, bcl, bax, wild, phenotypes, apoptotic, graph,
Topics {✒️}
casp3⇒casp8⇒bax⇒momp⇒smac⊣ciap⇒rip1ub⇒ikk⇒nfκb nfκb⇒cflip⊣casp8⇒bax⇒momp⇒cyt_c⇒apoptosome⇒casp3 casp3⇒casp8⇒bax⇒momp⇒cyt_c⇒apoptosome⇒casp3 nfκb⇒cflip⊣casp8⊣rip1⇒rip1ub⇒ikk⇒nfκb mpt⇒momp⇒smac⊣ciap⇒rip1ub⇒ikk⇒nfκb casp3⇒casp8⇒bax⇒momp⇒smac⊣xiap⊣casp3 nfκb⇒bcl2⊣bax⇒momp⇒cyt_c⇒apoptosome⇒casp3 casp3⇒casp8⊣rip1⇒rip1ub⇒ikk⇒nfκb tnf/egf/insulin-induced signaling nfκb⇒cflip⊣casp8⊣rip1⇒rip1k⇒ros⇒mpt mpt⇒momp⇒smac⊣xiap⊣apoptosome⇒casp3 tnf-induced nf-kappab signal nf-kappab-mediated xiap expression casp3⇒casp8⊣rip1⇒rip1k⇒ros⇒mpt activation-induced t-cell proliferation nfκb⇒ciap⇒rip1ub⇒ikk⇒nfκb caspase inhibitor z-vad-fmk induced nf-kappab activation mpt⇒momp⇒cyt_c⇒apoptosome⇒casp3 rip1-kinase-dependent pathway leading bcl-2 homologue a1/bfl-1 mpt⇒momp⇒smac⊣xiap⊣casp3 induce tnfalpha-dependent apoptosis smac iap-interacting motif qualitative results anti-oxidant apaf-1/caspase-9 complex initiates pmc beta search z-vad-fmk treatment match cell-specific behaviours nk-mediated cell death �z-vad mutant” simulates death receptor–induced apoptosis death receptor-induced apoptosis inhibit tnf-induced apoptosis caspase-independent cell killing nfκb⇒xiap⊣apoptosome⇒casp3 death receptor-mediated signals mitochondria-dependent apoptotic pathway provide counter-intuitive insights z-vad+rip1 deletion caspase-dependent apoptosis pathway nuclear factor-kappab tnf-induced nfκb activation necrotic pathways rip1-dependent induce ciap1/2 auto-ubiquitination biologically plausible phenotypes killing virus-infected cells mutual inhibitory cross-talks mice lacking fadd/mort1 nf-kappab activation
Questions {❓}
- Given a set of reachable stable states, can we say something about their relative “attractivity”?
- How could this hypothesis be experimentally assessed?
- How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
- This consideration led us to address the following questions: (i) Does a cluster structure exist in the distribution of internal stable states of the network?
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Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi