
NCBI . NLM . NIH . GOV {
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Title[redir]:
Temporal self-organization of the cyclin/Cdk network driving the mammalian cell cycle - PMC
Description:
We propose an integrated computational model for the network of cyclin-dependent kinases (Cdks) that controls the dynamics of the mammalian cell cycle. The model contains four Cdk modules regulated by reversible phosphorylation, Cdk inhibitors, and ...
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Keywords {🔍}
cell, cyclin, doi, cycle, cdk, fig, google, scholar, oscillations, pubmed, model, network, bcdk, mammalian, peak, acdk, activation, point, progression, checkpoint, pmc, modules, dna, oscillatory, cyclincdk, restriction, article, control, cellcycle, cells, transition, presence, prb, appendix, free, repetitive, state, ecdk, module, complexes, occur, threshold, dynamics, steady, phases, conditions, sustained, circuits, replication, parameter,
Topics {✒️}
org/cgi/content/full/0903827106/dcsupplemental cdh1/anaphase-promoting complex pathway dans l'agriculture pmc beta search supplementary materials included mammalian cyclin-dependent kinases rb-related genes leads supporting information online normal cell-cycle progression steady-state curve drawn blue lines represent eukaryotic cell-cycle regulation g1/s-regulatory genes trends biochem sci promotes cell-cycle progression vertical lines drawn cell-cycle phases closer publisher site pdf license information pmcid cdk-induced cyclin degradation controls cell-cycle progression cyclin/cdk complexes occurs [google scholar] 4 [google scholar] active cyclin/cdk complexes limit cycle type stable steady states cyclin/cdk complexes corresponds cyclin/cdk complexes occur cyclin/cdk network driving cell-cycle phases g1 mitotic oscillator driving atr/chk1 pathway rb/e2f pathway full cdk network nat rev cancer united states government rna primers synthesized tumor suppressor p53 guest editor invited xenopus oocyte extracts orr-weaver tl nat cell biol mol biol cell mol cell biol eukaryotic cell cycle chk1 checkpoint pathway stable steady state mitotic clock fails steady state recovers
Questions {❓}
- CDC25 phosphatases in cancer cells: Key players?
- Cyclin-dependent kinases and cell-cycle transitions: Does one fit all?
- What is the restriction point?
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