
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Dual effects of TGF-β on ERα-mediated estrogenic transcriptional activity in breast cancer - PMC
Description:
TGF-β resistance often develops in breast cancer cells that in turn overproduce this cytokine to create a local immunosuppressive environment that fosters tumor growth and exacerbates the invasive and metastatic behavior of the tumor cells ...
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Keywords {🔍}
smad, breast, tgfβ, cancer, doi, cells, expression, erα, pubmed, google, scholar, cell, transcription, carcinoma, human, growth, signaling, estrogen, mcf, activity, infiltrating, erαpositive, protein, figure, inhibition, ductal, genes, transcriptional, gene, receptor, complex, treated, role, tumor, mdamb, pmc, tissue, results, nucleus, shown, erαmediated, dna, cmyc, sirna, lines, benign, target, assay, hours, antibodies,
Topics {✒️}
transforming growth factor-beta anti-estrogen-dependent growth inhibition tgf-β-treated mda-mb-231 cells pmc beta search transforming growth factor-β erα-positive breast carcinoma tgf-beta induces assembly erα-mediated estrogenic activity estrogen-induced gene transcription signet-ring cell carcinoma inhibit erα-induced transcription erα-mediated gene transcription reconstituted erα-mediated signaling competing interests β-actin upper primer β-actin lower primer tgf-β stimulated translocation stimulated estrogen-induced ps2 phosphorylated r-smad associates serial paraffin-embedded sections tgf-β stimulation contributes mediate tgf-β suppression tgf-β-mediated repression infiltrating ductal carcinoma tgf-β-mediated inhibition biotin-labeled wild-type activate er-target genes intact tgf-β/smad tgf-β-induced phosphorylation dual-luciferase™ assay kit tgf-β growth inhibition erα-mediated transcriptional activation tgf-β signaling components acute myelogenous leukemia tgf-β signaling pathway elevated tgf-β expression real-time pcr frequent tgf-β resistance tgf-β responsive genes endogenous β-actin mrna regulates gene transcription c-myc upper primer c-myc lower primer license information pmcid smads-mediated cross-talk erα-induced transcription benign ductal epithelial human breast tissue human breast carcinoma tgfbeta anti-proliferative control
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