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tnf-alpha-related apoptosis-inducing ligand releases tumour-necrosis factor-alpha nature portfolio journals tnf-related apoptosis-inducing ligand trail-r2/killer/dr5 mrna isoforms permissions reprints privacy policy nature portfolio european research council advertising open-label study il6/stat3-dependent trail expression cancer research uk c-jun n-terminal kinase apoptosis-inducing ligand belonging trail/apo2l gene-deficient mice trail-mediated dr5-disc formation trail-based pro-apoptotic therapies social media tumor necrosis factor tumour necrosis factor rankl/opg/trail plasma levels agonistic trail-r2-specific antibody cycloheximide-sensitive factor occurs death-inducing signalling complex membrane-targeted death ligand modern research death receptor–ligand systems endotoxin-induced serum factor trail/dr5-dependent suppression induced trail-induced programmed necrosis cell-surface death ligand cyclooxygenase-dependent tumor growth myeloid-derived suppressor cells membrane-bound fas ligand tumor-cell-derived interleukin-4 trail-r2-targeting nanobody tas266 death receptor-induced apoptosis retinoic acid-induced apoptosis scientific adviser ifn-gamma-dependent suppression antonella montinaro & henning walczak modulates fasl-induced cytotoxicity author correspondence tumor-supportive immune microenvironment proapoptotic ligand apo2l/trail trail-induced apoptosis mediated university college london trail-r2- mediated apoptosis trail-r-mediated apoptosis

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• Bortezomib and TRAIL: a perfect match for apoptotic elimination of tumour cells?
• Is TRAIL the holy grail of cancer therapy?
• Metastasis suppressor function of tumor necrosis factor-related apoptosis-inducing ligand-R in mice: implications for TRAIL-based therapy in humans?

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