
DOI . ORG {
}
Title[redir]:
Enhancing the antitumor efficacy of a cell-surface death ligand by covalent membrane display | PNAS
Description:
TNF superfamily death ligands are expressed on the surface of immune cells and can trigger apoptosis in susceptible cancer cells by engaging cognate death receptors. A recombinant soluble protein c...
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Keywords {🔍}
apoltrail, caspase, fig, cell, apol, pubmed, crossref, google, scholar, cancer, cells, death, ligand, activity, apoll, tumor, receptor, tumors, display, apolm, efficacy, apoptosis, membrane, liposomes, view, proapoptotic, articles, antitumor, signaling, lines, liposomal, author, recombinant, apolxl, article, ashkenazi, potency, information, soluble, activation, clinical, protein, human, mol, research, therapeutic, supported, exposure, pnas, induced,
Topics {✒️}
integrin-binding cyclic arg-gly-asp pan-caspase inhibitor zvad-fmk tumour-necrosis factor superfamily death-inducing signaling complex social media facebook niche–efficiency jingjing liang jan-willem van ittersum death receptor-induced apoptosis authors affiliations pradeep pro-apoptotic receptor agonists covalent synthetic-membrane attachment death receptor-expressing cells dynamic light scattering leucine-rich repeat domain nb-7gfp-c8 cells cell-surface death ligand kelley pharmaceutical development require fc-cross-linking recombinant human apo2l/trail small-molecule bcl-2 antagonists antibody-cross-linked version apo2l/trail yields functional national academy current emotional state related individual variability sds-hplc analysis revealed recombinant apo2l/trail proteins recombinant apo2l/trail versions small-cell lung cancer ligand-exposed normal tissues nonlinear mixed-effect model covalent cysteine–maleimide bonds recombinant soluble apo2l/trail apo2l/trail overcome chemoresistance liposome-based drug delivery apo2l/trail markedly improves size-exclusion chromatography supported pnas direct submission polyhistidine-tagged apo2l/trail covalently attaching apo2l/trail ht-29 colorectal carcinoma subsequent cell-membrane blebbing apo2l/trail augments activity confirming receptor ligation sophisticated auditory–motor learning 1 μg/ml apo2l/trail quantify apo2l/trail protein tnf superfamily ligand higher-molecular-weight fractions apo2l/trail enhances activity
Questions {❓}
- PM Holland, Death receptor agonist therapies for cancer, which is the right TRAIL?
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Emails and Hosting {✉️}
Mail Servers:
- mx.zoho.eu
- mx2.zoho.eu
- mx3.zoho.eu
Name Servers:
- josh.ns.cloudflare.com
- zita.ns.cloudflare.com