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Title[redir]:
Metastasis suppressor function of TRAIL-R in mice- implications for TRAIL-based therapy in humans? - PMC
Description:
TRAIL is a promising candidate for cancer therapy, as it can induce apoptosis specifically in tumor cells but not in normal cells. While earlier mouse tumor studies revealed a strong tissue dependency of TRAIL and its death receptor in suppressing ...
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Keywords {🔍}
trail, tumor, cells, metastasis, doi, trailr, primary, cancer, pubmed, google, scholar, death, mice, apoptosis, suppressor, skin, system, receptors, carcinoma, apoptosisinducing, cell, pmc, function, metastases, tumors, metastatic, tumorigenesis, formation, detachment, resistance, expression, nlm, increased, effect, signaling, res, therapy, sensitization, pathway, ncbi, search, role, ligand, caspase, suppressors, necrosis, factorrelated, lee, humans, article,
Topics {✒️}
irradiated trail-r-deficient mice trail-r-mediated apoptosis signaling dr5/killer/trick2/apo2 trail-related tumor therapy trail-r-mediated apoptosis death receptor-mediated apoptosis apoptosis-inducing trail system apoptosis-inducing trail/trail graft-versus-tumor effect phosphatidylinositol 3-kinase/akt pathway trail-r-deficient mice promising anti-tumor strategy mediate anti-tumor effects tumor stage-dependent manner ifn-gamma-dependent suppression pmc beta search tumor cell-specific effects tumor free survival apoptosis-inducing trail trail-sensitive tumor cells trail-receptor-targeting drugs trail-receptor targeting drugs nk cell-mediated trail induced apoptosis trail-induced apoptosis induce apoptosis specifically skin carcinoma cells detached carcinoma cells publisher site pdf subcutaneous tumor growth ifn-gamma activation extrinsic apoptosis pathway anti-tumor effect trail-deficient mice detachment-induced trail sensitization trail-based therapy ovarian carcinoma cells metastatic cell lines tumor suppressors leads trail apoptosis pathway primary tumor cells lung nk cells biochem cell biol breast carcinoma cells expressing functional trail primary skin carcinomas primary human cancers carcinoma cells isolated trail-r-independent lymph node metastases
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- Metastasis suppressor function of TRAIL-R in mice- implications for TRAIL-based therapy in humans?
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