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Necroptosis and its role in inflammation | Nature
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Regulated cell death has essential functions in development and in adult tissue homeostasis. Necroptosis is a newly discovered pathway of regulated necrosis that requires the proteins RIPK3 and MLKL and is induced by death receptors, interferons, toll-like receptors, intracellular RNA and DNA sensors, and probably other mediators. RIPK1 has important kinase-dependent and scaffolding functions that inhibit or trigger necroptosis and apoptosis. Mouse-model studies have revealed important functions for necroptosis in inflammation and suggested that it could be implicated in the pathogenesis of many human inflammatory diseases. We discuss the mechanisms regulating necroptosis and its potential role in inflammation and disease.
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nature portfolio privacy policy receptor-interacting kinase-3-mediated pathway author information authors advertising tnf-induced nf-ฮบb signal rip1โrip3-drp1 signaling pathway permissions reprints social media european research council german research foundation research foundation flanders induce tnfฮฑ-dependent apoptosis ripk3-dependent necroptosis mediated rip3-mediated macrophage necrosis necrotic mem-brane disruption tnf-induced keratinocyte apoptosis dsrna-induced retinal degeneration smac-mimetic-induced apoptosis pka/creb/ripk1 axis caspase-independent apoptosis pathway rip3-rip3 homo-interaction pro-necrotic kinase activity dai/zbp1/dlm-1 complexes nf-ฮบb activation liver ischemia/reperfusion rip1/rip3 necrosome forms receptor 3-mediated necrosis tnf-ฮฑ feedforward signaling nature cell biol tnfr1-induced inflammatory mediates noncanonical il-1ฮฒ human inflammatory diseases fas/cd95-induced chemokines diverse cell-death patterns personal data early postnatal lethality tnfฮฑ-dependent apoptosis research virus-induced inflammation springerlink instant access innate immune defense intestinal epithelial cells data protection reduces allograft survival canonical nf-ฮบb tnf-induced necrosis prevents skin inflammation important kinase-dependent specific cellular target
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headline:Necroptosis and its role in inflammation
description:Regulated cell death has essential functions in development and in adult tissue homeostasis. Necroptosis is a newly discovered pathway of regulated necrosis that requires the proteins RIPK3 and MLKL and is induced by death receptors, interferons, toll-like receptors, intracellular RNA and DNA sensors, and probably other mediators. RIPK1 has important kinase-dependent and scaffolding functions that inhibit or trigger necroptosis and apoptosis. Mouse-model studies have revealed important functions for necroptosis in inflammation and suggested that it could be implicated in the pathogenesis of many human inflammatory diseases. We discuss the mechanisms regulating necroptosis and its potential role in inflammation and disease.
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description:Regulated cell death has essential functions in development and in adult tissue homeostasis. Necroptosis is a newly discovered pathway of regulated necrosis that requires the proteins RIPK3 and MLKL and is induced by death receptors, interferons, toll-like receptors, intracellular RNA and DNA sensors, and probably other mediators. RIPK1 has important kinase-dependent and scaffolding functions that inhibit or trigger necroptosis and apoptosis. Mouse-model studies have revealed important functions for necroptosis in inflammation and suggested that it could be implicated in the pathogenesis of many human inflammatory diseases. We discuss the mechanisms regulating necroptosis and its potential role in inflammation and disease.
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