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We are analyzing https://www.nature.com/articles/emm200960.

Title:
Nuclear receptor regulation of stemness and stem cell differentiation | Experimental & Molecular Medicine
Description:
Stem cells include a diverse number of toti-, pluri-, and multi-potent cells that play important roles in cellular genesis and differentiation, tissue development, and organogenesis. Genetic regulation involving various transcription factors results in the self-renewal and differentiation properties of stem cells. The nuclear receptor (NR) superfamily is composed of 48 ligand-activated transcription factors involved in diverse physiological functions such as metabolism, development, and reproduction. Increasing evidence shows that certain NRs function in regulating stemness or differentiation of embryonic stem (ES) cells and tissue-specific adult stem cells. Here, we review the role of the NR superfamily in various aspects of stem cell biology, including their regulation of stemness, forward- and trans-differentiation events; reprogramming of terminally differentiated cells; and interspecies differences. These studies provide insights into the therapeutic potential of the NR superfamily in stem cell therapy and in treating stem cell-associated diseases (e.g., cancer stem cell).
Website Age:
30 years and 10 months (reg. 1994-08-11).

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Science
Education
Telecommunications

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Custom-built

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🚀🌠 Tremendous Traffic: 10M - 20M visitors per month

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$213,500 per month
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Keywords {🔍}

cells, pubmed, stem, google, scholar, cas, cell, differentiation, receptor, expression, mouse, nuclear, adult, central, embryonic, neural, nrs, human, nature, pparγ, adipogenesis, oct, orphan, role, regulation, development, pluripotent, activation, factor, involved, induced, mesenchymal, biol, adipogenic, brain, mol, factors, transdifferentiation, bone, transcription, progenitor, treatment, gcnf, errβ, proliferation, tlx, function, pathway, myogenic, important,

Topics {✒️}

nature portfolio research tools privacy policy peroxisome proliferator-activated receptor-gamma advertising social media estrogen-related receptor beta tgf-beta-induced epithelial reprints author information authors quantitative real-time pcr nature 2008a ppar-gamma regulates osteoclastogenesis research purposes research resources rar-mediated chondrogenic regulation twentyone/myeloid translocation gene author correspondence ra-induced mir134 attenuates androgen receptor/ beta-catenin nature 2007 nature 2009 nature 1997 nature 2008 nature 2004 nature 2006 nature androgen receptor-mediated pathway tissue-specific progenitor cells tissue-specific stem cells directs lineage-specific differentiation research stem cell-specific expression van der kooy van den berg full size image estrogen-receptor-dependent regulation ligand-binding domain personal data sequentially induces de-repression nr4a-mediated adipogenic inhibition nur-related factor 1 stem cell medicine ubiquitin-mediated degradation translational science initiative smrt-hdac complex bound induced pluripotent stem pluripotent cells derived cell line derived orphan nuclear receptor

Schema {🗺️}

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External Links {🔗}(279)

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