
NCBI . NLM . NIH . GOV {
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Title[redir]:
PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors - PMC
Description:
Based on the fact that aging is associated with a reciprocal decrease of osteogenesis and an increase of adipogenesis in bone marrow and that osteoblasts and adipocytes share a common progenitor, this study investigated the role of PPARγ, a key ...
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Keywords {🔍}
pparγ, bone, doi, cells, marrow, google, scholar, pubmed, mice, culture, cell, differentiation, adipogenesis, osteoblasts, adipocytes, osteoblast, insulin, figure, leptin, expression, formation, days, littermates, compared, weeks, number, osteogenesis, haploinsufficiency, signaling, gene, cultured, staining, red, osteoblastogenesis, osteogenic, vivo, fbs, determined, pmc, age, stained, loss, mass, cultures, factor, study, adipocyte, receptor, growth, density,
Topics {✒️}
peroxisome proliferator-activated receptor-γ high-fat diet–induced obesity real-time quantitative rt-pcr peroxisome proliferator-activated receptor pmc beta search tartrate-resistant acid phosphatase–positive ccaat/enhancer binding protein-α ligand-activated transcription factor lipid-activated transcription factor tgf-β-induced repression real-time pcr analysis glycogen synthase kinase-3β tartrate-resistant acid phosphatase ccaat enhancer-binding proteins pbabe-mpparγ2-puro vector soft x-ray apparatus pmc copyright notice von kossa–positive nodules long-chain fatty acids suppress c-fos expression make single-stranded cdna plain x-ray images tris-hcl–buffered solution m-csf/soluble rankl genome-wide expression analysis trypan blue–negative osteoclasts quantitative rt-pcr odf/rankl-rank interaction pituitary-specific gene expression high bone mass publisher site pdf transcription factor implicated tgf-β/smad3 signaling homozygous pparγ-deficient heterozygous pparγ-deficient human age-related osteoporosis pparγ gene–targeted mice control rx-vector altered leukemia inhibitory factor high bone turnover ppar γ controls m-bmmφ culture system cytosolic β-catenin license information pmcid age-related bone loss steady-state mrna levels bone metabolism induced pparγ-responsive element ppre soluble receptor activator /ebp-δ lie upstream
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