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Title:
The role of mRNA m6A methylation in the nervous system | Cell & Bioscience
Description:
Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery following the deoxyribonucleic acid (DNA) and histone methylation. Messenger RNA (mRNA) methylation modification accounts for more than 60% of all RNA modifications and N6-methyladenosine (m6A) is known as one of the most common type of eukaryotic mRNA methylation modifications in current. The m6A modification is a dynamic reversible modification, which can directly or indirectly affect biological processes, such as RNA degradation, translation and splicing, and can play important biological roles in vivo. This article introduces the mRNA m6A methylation modification enzymes and binding proteins, and reviews the research progress and related mechanisms of the role of mRNA m6A methylation in the nervous system from the aspects of neural stem cells, learning and memory, brain development, axon growth and glioblastoma.
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pubmed, article, google, scholar, cas, mrna, rna, central, methylation, cell, fto, modification, protein, mettl, nmethyladenosine, cells, brain, stem, gene, wang, role, zhang, binding, liu, methyltransferase, regulates, ythdf, biol, memory, mouse, translation, res, regulation, proteins, neural, expression, learning, demethylase, genes, growth, complex, function, system, yang, development, nervous, modifications, important, domain, nuclear,
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headline:The role of mRNA m6A methylation in the nervous system
description:Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery following the deoxyribonucleic acid (DNA) and histone methylation. Messenger RNA (mRNA) methylation modification accounts for more than 60% of all RNA modifications and N6-methyladenosine (m6A) is known as one of the most common type of eukaryotic mRNA methylation modifications in current. The m6A modification is a dynamic reversible modification, which can directly or indirectly affect biological processes, such as RNA degradation, translation and splicing, and can play important biological roles in vivo. This article introduces the mRNA m6A methylation modification enzymes and binding proteins, and reviews the research progress and related mechanisms of the role of mRNA m6A methylation in the nervous system from the aspects of neural stem cells, learning and memory, brain development, axon growth and glioblastoma.
datePublished:2019-08-20T00:00:00Z
dateModified:2019-08-20T00:00:00Z
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Epitranscriptomics
N6-methyladenosine (m6A)
Methyltransferase
Demethylase
Binding protein
Nervous system
Cell Biology
Microbiology
Stem Cells
Neurobiology
Proteomics
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headline:The role of mRNA m6A methylation in the nervous system
description:Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery following the deoxyribonucleic acid (DNA) and histone methylation. Messenger RNA (mRNA) methylation modification accounts for more than 60% of all RNA modifications and N6-methyladenosine (m6A) is known as one of the most common type of eukaryotic mRNA methylation modifications in current. The m6A modification is a dynamic reversible modification, which can directly or indirectly affect biological processes, such as RNA degradation, translation and splicing, and can play important biological roles in vivo. This article introduces the mRNA m6A methylation modification enzymes and binding proteins, and reviews the research progress and related mechanisms of the role of mRNA m6A methylation in the nervous system from the aspects of neural stem cells, learning and memory, brain development, axon growth and glioblastoma.
datePublished:2019-08-20T00:00:00Z
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Epitranscriptomics
N6-methyladenosine (m6A)
Methyltransferase
Demethylase
Binding protein
Nervous system
Cell Biology
Microbiology
Stem Cells
Neurobiology
Proteomics
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