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  6. Keywords
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We began analyzing https://www.nature.com/articles/mp201449, but it redirected us to https://www.nature.com/articles/mp201449. The analysis below is for the second page.

Title[redir]:
FTO genotype and aging: pleiotropic longitudinal effects on adiposity, brain function, impulsivity and diet | Molecular Psychiatry
Description:
Although overweight and obesity are associated with poor health outcomes in the elderly, the biological bases of obesity-related behaviors during aging are poorly understood. Common variants in the FTO gene are associated with adiposity in children and younger adults as well as with adverse mental health in older individuals. However, it is unclear whether FTO influences longitudinal trajectories of adiposity and other intermediate phenotypes relevant to mental health during aging. We examined whether a commonly carried obesity-risk variant in the FTO gene (rs1421085 single-nucleotide polymorphism) influences adiposity and is associated with changes in brain function in participants within the Baltimore Longitudinal Study of Aging, one of the longest-running longitudinal aging studies in the United States. Our results show that obesity-related risk allele carriers of FTO gene show dose-dependent increments in body mass index during aging. Moreover, the obesity-related risk allele is associated with reduced medial prefrontal cortical function during aging. Consistent with reduced brain function in regions intrinsic to impulse control and taste responsiveness, risk allele carriers of FTO exhibit dose-dependent increments in both impulsivity and intake of fatty foods. We propose that a common neural mechanism may underlie obesity-associated impulsivity and increased consumption of high-calorie foods during aging.

Matching Content Categories {📚}

  • Education
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  • Science

Content Management System {📝}

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Custom-built

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

article, google, scholar, aging, cas, obesity, fto, study, nature, gene, baltimore, longitudinal, access, usa, mass, association, content, brain, index, function, information, psychiatry, impulsivity, obesityrelated, common, adults, risk, body, cookies, health, variants, older, disease, genet, research, national, privacy, data, adiposity, genetic, med, alzheimers, institute, powerpoint, molecular, effects, mental, allele, fat, adult,

Topics {✒️}

nature portfolio permissions reprints privacy policy nature intramural research program late middle age advertising development contract n01-ag-3-2124 author information authors aging research social media professional manual research development core team author correspondence age-specific incidence rates nincds-adrda work group obesity-related genetic polymorphisms rs1421085 single-nucleotide polymorphism body mass index permissions video content analysis obesity-related risk allele springerlink instant access costa pt lakatta costa pt jr personal data de wit commonly carried allele florida state university obesity-related fto gene data protection nchs data risk allele carriers prefrontal cortical inactivation medial prefrontal cortex privacy development reduced brain volume government printing office whitehall ii study j- shipp study reduced brain function common neural mechanism fto variants rs9939609 european economic area intermediate phenotypes relevant institutional subscriptions read obese persons portrayed mri brain volumes

Questions {❓}

  • Review: does measurement of regional cerebral blood flow reflect synaptic activity?

Schema {🗺️}

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         description:Although overweight and obesity are associated with poor health outcomes in the elderly, the biological bases of obesity-related behaviors during aging are poorly understood. Common variants in the FTO gene are associated with adiposity in children and younger adults as well as with adverse mental health in older individuals. However, it is unclear whether FTO influences longitudinal trajectories of adiposity and other intermediate phenotypes relevant to mental health during aging. We examined whether a commonly carried obesity-risk variant in the FTO gene (rs1421085 single-nucleotide polymorphism) influences adiposity and is associated with changes in brain function in participants within the Baltimore Longitudinal Study of Aging, one of the longest-running longitudinal aging studies in the United States. Our results show that obesity-related risk allele carriers of FTO gene show dose-dependent increments in body mass index during aging. Moreover, the obesity-related risk allele is associated with reduced medial prefrontal cortical function during aging. Consistent with reduced brain function in regions intrinsic to impulse control and taste responsiveness, risk allele carriers of FTO exhibit dose-dependent increments in both impulsivity and intake of fatty foods. We propose that a common neural mechanism may underlie obesity-associated impulsivity and increased consumption of high-calorie foods during aging.
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      headline:FTO genotype and aging: pleiotropic longitudinal effects on adiposity, brain function, impulsivity and diet
      description:Although overweight and obesity are associated with poor health outcomes in the elderly, the biological bases of obesity-related behaviors during aging are poorly understood. Common variants in the FTO gene are associated with adiposity in children and younger adults as well as with adverse mental health in older individuals. However, it is unclear whether FTO influences longitudinal trajectories of adiposity and other intermediate phenotypes relevant to mental health during aging. We examined whether a commonly carried obesity-risk variant in the FTO gene (rs1421085 single-nucleotide polymorphism) influences adiposity and is associated with changes in brain function in participants within the Baltimore Longitudinal Study of Aging, one of the longest-running longitudinal aging studies in the United States. Our results show that obesity-related risk allele carriers of FTO gene show dose-dependent increments in body mass index during aging. Moreover, the obesity-related risk allele is associated with reduced medial prefrontal cortical function during aging. Consistent with reduced brain function in regions intrinsic to impulse control and taste responsiveness, risk allele carriers of FTO exhibit dose-dependent increments in both impulsivity and intake of fatty foods. We propose that a common neural mechanism may underlie obesity-associated impulsivity and increased consumption of high-calorie foods during aging.
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External Links {🔗}(206)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
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