We are analyzing https://link.springer.com/article/10.1186/s13046-024-02960-w.

Title:
T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution | Journal of Experimental & Clinical Cancer Research
Description:
Tumor-infiltrating T cells recognize, attack, and clear tumor cells, playing a central role in antitumor immune response. However, certain immune cells can impair this response and help tumor immune escape. Therefore, exploring the factors that influence T-cell infiltration is crucial to understand tumor immunity and improve therapeutic effect of cancer immunotherapy. The use of single-cell RNA sequencing (scRNA-seq) allows the high-resolution analysis of the precise composition of immune cells with different phenotypes and other microenvironmental factors, including non-immune stromal cells and the related molecules in the tumor microenvironment of various cancer types. In this review, we summarized the research progress on T-cell infiltration and the crosstalk of other stromal cells and cytokines during T-cell infiltration using scRNA-seq to provide insights into the mechanisms regulating T-cell infiltration and contribute new perspectives on tumor immunotherapy.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

cells, pubmed, cancer, tumor, infiltration, article, tcell, cell, immune, google, scholar, tumors, cas, central, singlecell, expression, cold, high, macrophages, immunotherapy, microenvironment, cafs, hot, scrnaseq, tme, analysis, ccl, zhang, nat, tams, response, wang, liu, heterogeneity, breast, levels, cxcl, tecs, fibroblasts, antitumor, immunosuppressive, carcinoma, infiltrating, lung, genes, mechanisms, interactions, inhibit, expressing, yang,

Topics {✒️}

akt/gsk3β/β-catenin/tcf4 signaling pathway ras-pi3k-akt-mtor signaling pathway smad2/3-jak/stat3 signaling cascade high-resolution scrna-seq enables wdr5–h3k4me3 epigenetic axis tgf-β signaling pathway mhc-ii-mediated antigen presentation single-cell rna sequencing multiple scrna-seq-based investigations single-cell rna-seq article download pdf multiregional single-cell dissection myeloid-derived suppressor cells anti-pd-l1 blockade cell-mediated immune responses mapping single-cell transcriptomes pd-l1/pd-1 pathway regulate t-cell infiltration integrating paired ligand-receptor single-cell transcriptomic analysis integrated single-cell atlas promote t-cell rejection anti-pd-l1 immunotherapy minimal t-cell infiltration modulate t-cell infiltration promote t-cell infiltration high-affinity nonspecific receptor t-cell exclusion induction developing anti-il-6 agents tissue-resident memory subset limited t-cell infiltration high t-cell infiltration evade t-cell killing tgf-β signaling upregulating tgf-β expression t-cell infiltration status promotes t-cell exhaustion highly express mhc-ii tumor-promoting m2-type macrophages low t-cell infiltration inhibit cd8 + t-cell recruitment t-cell infiltration patterns suppress t-cell infiltration enhancing t-cell responses myh11+αsma+ caf subpopulation promote t-cell proliferation cells t-cell receptor influence t-cell infiltration inhibiting t-cell infiltration induce t-cell incompetence

Schema {🗺️}

WebPage:
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         headline:T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution
         description:Tumor-infiltrating T cells recognize, attack, and clear tumor cells, playing a central role in antitumor immune response. However, certain immune cells can impair this response and help tumor immune escape. Therefore, exploring the factors that influence T-cell infiltration is crucial to understand tumor immunity and improve therapeutic effect of cancer immunotherapy. The use of single-cell RNA sequencing (scRNA-seq) allows the high-resolution analysis of the precise composition of immune cells with different phenotypes and other microenvironmental factors, including non-immune stromal cells and the related molecules in the tumor microenvironment of various cancer types. In this review, we summarized the research progress on T-cell infiltration and the crosstalk of other stromal cells and cytokines during T-cell infiltration using scRNA-seq to provide insights into the mechanisms regulating T-cell infiltration and contribute new perspectives on tumor immunotherapy.
         datePublished:2024-02-02T00:00:00Z
         dateModified:2024-02-02T00:00:00Z
         pageStart:1
         pageEnd:18
         license:http://creativecommons.org/publicdomain/zero/1.0/
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         keywords:
            Single-cell RNA sequencing
            Tumor microenvironment
            T-cell infiltration
            “hot tumors” and “cold tumors”
            Stromal cells
            Cancer Research
            Immunology
            Apoptosis
            Oncology
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ScholarlyArticle:
      headline:T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution
      description:Tumor-infiltrating T cells recognize, attack, and clear tumor cells, playing a central role in antitumor immune response. However, certain immune cells can impair this response and help tumor immune escape. Therefore, exploring the factors that influence T-cell infiltration is crucial to understand tumor immunity and improve therapeutic effect of cancer immunotherapy. The use of single-cell RNA sequencing (scRNA-seq) allows the high-resolution analysis of the precise composition of immune cells with different phenotypes and other microenvironmental factors, including non-immune stromal cells and the related molecules in the tumor microenvironment of various cancer types. In this review, we summarized the research progress on T-cell infiltration and the crosstalk of other stromal cells and cytokines during T-cell infiltration using scRNA-seq to provide insights into the mechanisms regulating T-cell infiltration and contribute new perspectives on tumor immunotherapy.
      datePublished:2024-02-02T00:00:00Z
      dateModified:2024-02-02T00:00:00Z
      pageStart:1
      pageEnd:18
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         Single-cell RNA sequencing
         Tumor microenvironment
         T-cell infiltration
         “hot tumors” and “cold tumors”
         Stromal cells
         Cancer Research
         Immunology
         Apoptosis
         Oncology
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                  address:
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                     type:PostalAddress
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            affiliation:
                  name:Fifth Medical Center of Chinese PLA General Hospital
                  address:
                     name:State Key Laboratory of Experimental Hematology, Senior Department of Hematology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China
                     type:PostalAddress
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            affiliation:
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            type:Person
            name:Tianyu Lei
            affiliation:
                  name:Renmin Hospital of Wuhan University
                  address:
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                     type:PostalAddress
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            url:http://orcid.org/0000-0002-3807-9901
            affiliation:
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                  name:Renmin Hospital of Wuhan University
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                     type:PostalAddress
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            type:Person
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         type:PostalAddress
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               type:PostalAddress
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      name:Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China
      name:Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China
      name:State Key Laboratory of Experimental Hematology, Senior Department of Hematology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China
      name:Department of Medical Oncology, Peking University First Hospital, Beijing, China
      name:Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China
      name:Department of Radiation Oncology, Peking University First Hospital, Beijing, China
      name:Department of Medical Oncology, Peking University First Hospital, Beijing, China
      name:Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China

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