
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Single cell genomic characterization reveals the cellular reprogramming of the gastric tumor microenvironment - PMC
Description:
The tumor microenvironment (TME) consists of a heterogenous cellular milieu that can influence cancer cell behavior. Its characteristics have an impact on treatments such as immunotherapy. These features can be revealed with single-cell RNA ...
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Keywords {🔍}
cells, doi, cell, supplementary, figure, tumor, normal, expression, google, scholar, pubmed, gene, genes, cancer, tme, pmc, tissue, article, gastric, free, analysis, transcriptional, table, epithelial, cluster, singlecell, immune, identified, type, clusters, detected, compared, states, patients, cellular, distinct, methods, subclasses, macrophages, data, stromal, expressed, endothelial, samples, clustering, markers, patient, tumors, fibroblasts, differences,
Topics {✒️}
single-cell rna-seq reveals single-cell rna-seq data early maternal-fetal interface single-cell rna-seq single-cell transcriptomic profiles pmc beta search single-cell rna sequencing single-cell gene expression dual single-cell proteomics conics integrates scrna-seq tumor-specific extracellular matrix single-cell dna sequencing marker-based lineage assignments tme-specific intercellular communication cxcl13-high tumor-tex cells small-cell lung cancer binary m1/m2 designation reflects stimulus-based context binary m1/m2 paradigm foxo transcription factors graph-based clustering colored ephrin receptor family network depicting interactions elucidate intra-tumor heterogeneity tumor-specific macrophages exist proteomic analyses including [google scholar] 12 [google scholar] 16 tumor-tex cells differed tumor-specific epithelial cells growth factor signaling integrin receptor interactions human cxcl13-producing cd4 dot plots depicting delineated cell-specific features inter-cellular interactions tumor-infiltrating macrophages differentiate tumor-specific endothelial cells showed differential enrichment extracellular matrix constituents differential gene expression gene signatures based single-cell analysis tumor-specific tex clusters highly expressed ido1 accurate supervised method single-cell suspension single-cell libraries single-cell reconstruction single data matrix
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- Anti-CTLA-4 antibodies in cancer immunotherapy: selective depletion of intratumoral regulatory T cells or checkpoint blockade?
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