
NCBI . NLM . NIH . GOV {
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Title[redir]:
An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion - PMC
Description:
Despite breakthroughs in immune checkpoint inhibitor (ICI) immunotherapy, not all human cancers respond to ICI immunotherapy and a large fraction of patients with the responsive types of cancers do not respond to current ICI immunotherapy. This ...
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Keywords {🔍}
cells, doi, mice, irf, opn, cell, tumor, pubmed, google, scholar, irfko, colon, figure, expression, pmc, activation, article, free, myeloid, cancer, human, analyzed, mouse, level, immune, protein, data, shown, blood, ova, factor, stained, significantly, immunol, dna, isre, transcription, deficiency, analysis, response, function, differentiation, antigenspecific, collected, chimera, spp, promoter, test, representative, mabs,
Topics {✒️}
cell-mediated graft-versus-host disease ctla-4/pd-1/pd-l1–independent immune suppression aom-dss–induced colon tumor-bearing experimental graft-versus-host disease aom-dss–induced colon carcinoma pd-1/pd-l1 immune checkpoints transcription factor nf-κb lineage-specific transcription factor protein a-agarose beads cell–mediated immune surveillance irf8-ko cd8+ ova-specific cox hazard-proportional model chip pcr-amplified regions supplementary materials included pmc beta search graft-versus-host opn+cd11b+gr1+ myeloid cells pd-l1 determines efficacy sjl-ptprca pepcb/boyj kaplan-meier survival analysis regulatory t-cell function ifn-γ protein level sustains virus-specific cd8+ cell–specific transcription factors decreased disease-specific survival 4t1 tumor-bearing balb/ major protein-dna complexes isre consensus sequence irf8-ko mice exhibited irf8-gfp reporter mice generate antigen-specific cd8+ generate ova-specific cd8+ lethally irradiated c57bl/6×sjl anti-cd28 mab-coated plates ova tetramer–specific antibodies anti-pd-l1 antibody irf8-ko chimera mice cytotoxic t-cell lymphocytes human dendritic-cell immunodeficiency irf8-ko mice tolerated pmc copyright notice cd8 t-cell recognition irf8-tko mice tolerate anti-irf8 antibody displaced antigen-driven effector cd8 tumor-free mice irf8-tko mice responded suppress tumor-reactive ctls cd11b+ly6cloly6g+ myeloid cells cd11b+gr1+ myeloid cells
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