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Keywords {🔍}

cells, tumor, cell, melanoma, fig, levels, patients, samples, independent, expression, tumors, supplementary, sdc, fltl, dcs, clone, data, doi, google, scholar, gene, pubmed, sdcs, biologically, mice, biolegend, antipd, survival, immunotherapy, signature, pmc, cancer, human, mouse, animals, article, fltlg, responsiveness, cohort, free, total, immune, patient, metastatic, correlation, tme, bdca, analysis, responses, increased,

Topics {✒️}

wnt/β-catenin pathway mutations biotin-conjugated anti-cd2 antibody p2a-icreert2-t2a-tfp sequence specific pathogen-free conditions efficient dna-mediated transfer pmc beta search single-read 50bp miseq batf3 deficiency reveals wilcoxon rank-sum test cutaneous/subcutaneous metastatic melanomas cross-present tumor antigens foxp3 clone 236a/e7 stably engage tumor-specific organ-specific cellular requirements hla-dr clone l243 anti-ctla-4 checkpoint blockade26 single-channel imaging reagents bdca3 clone ad5–14h12 mhc-ii clone m5/114 live-imaging pre-cdc anti-pd-1 checkpoint blockade cd45r clone ra3–6b2 1% penicillin/streptomycin/glutamine total hla-dr+ cells cd4 clone rpa-t4 provide pro-survival signals unpaired nonparametric mann-whitney anti-pd-1 “checkpoint” immunotherapy total mhc-ii+ cells cd8 clone rpa-t8 incoming pre-cdc precursors pre-anti-pd-1 immunotherapy wildtype c57bl/6j mice streptavidin-brilliant violet 650 anti-pd-1 responding patients nk cell-dc distances providing long-lasting protection identifying responsive patients20 paired single-cell analyses implicated dc-nk interactions tumor-draining lymph node kaplan-meier plot analysis profound anti-pd-1 responses sdc/nsm ratio signature nk-dc axis found cd45 clone 30-f11 transferred ubiquitin-cfp ot median-based z-score kaplan-meier survival plots primary melanoma lesion

Questions {❓}

• However, NK cells and SDCs are quite rare in the tumor, thus we asked: how do NK cells exert control on SDCs in the tumor?

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