
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma - PMC
Description:
Interaction between tumor cells and immune cells in the tumor microenvironment is important in cancer development. Immune cells interact with the tumor cells to shape this process. Here, we use single-cell RNA sequencing analysis to delineate the ...
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Keywords {๐}
cells, doi, cell, hcc, tumor, pubmed, google, scholar, fig, immune, supplementary, expression, pmc, data, article, free, cancer, nectin, lair, immunosuppressive, macrophages, heterogeneity, hepatocellular, carcinoma, human, tams, landscape, interaction, singlecell, analysis, performed, single, study, tumors, information, status, tumorinfiltrating, liver, cases, marker, cnv, checkpoint, receptor, mouse, usa, patients, source, lcsc, case, findings,
Topics {โ๏ธ}
ligand-receptor-mediated multicellular signalling single-cell rna-seq supports bulk-cell rna-seq data cd45+cd3+cd4+cd25+foxp3+ crisprโcas9 ko system competing interests hydrodynamic tailโvein injection pmc beta search glut1-related energy metabolism independent single-guide rnas single-cell transcriptomics reveals single-cell rna sequencing unique multi-dimensional capacity tcga rna-seq datasets data availability statements data availability statement anti-mouse cd16/32 antibody irene oi-lin ng fluorochrome-conjugated primary antibodies anti-cd3/cd28 beads anti-tigit antibody tiragolumab anti-nectin2 neutralizing antibody c57/bl6n male mice resulting gene-barcode matrices cancer-promoting m2 tam efficacious immune-oncology treatments cancer-promoting immunocellular landscape visualizing single-cell data gene expressional similarity/difference anti-pd-l1 antibody syngeneic immune-competent mice orthotopically implanted hepa1โ6โntc inferred copy-number variation genome-wide cnv profile copy number information mhc i-lilrb axis pd-l1-selected nsclc pseudo-time cell trajectory cytotoxic t-cell response cancer-promoting immunosuppressive environment stemness-related subpopulations pd-1-pd-l1/l2 anti-pd-l1 blockade disease-free survival license information pmcid providing precise information supplementary information files native tumor-suppressive functions cancer-promoting m2 tams growth factor-1 secretion
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