We are analyzing https://link.springer.com/article/10.1186/s13045-020-00946-7.

Title:
Ferroptosis, necroptosis, and pyroptosis in anticancer immunity | Journal of Hematology & Oncology
Description:
In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has achieved considerable success in the clinic. However, ICIs are significantly limited by the fact that only one third of patients with most types of cancer respond to these agents. The induction of cell death mechanisms other than apoptosis has gradually emerged as a new cancer treatment strategy because most tumors harbor innate resistance to apoptosis. However, to date, the possibility of combining these two modalities has not been discussed systematically. Recently, a few studies revealed crosstalk between distinct cell death mechanisms and antitumor immunity. The induction of pyroptosis, ferroptosis, and necroptosis combined with ICIs showed synergistically enhanced antitumor activity, even in ICI-resistant tumors. Immunotherapy-activated CD8+ T cells are traditionally believed to induce tumor cell death via the following two main pathways: (i) perforin-granzyme and (ii) Fas-FasL. However, recent studies identified a new mechanism by which CD8+ T cells suppress tumor growth by inducing ferroptosis and pyroptosis, which provoked a review of the relationship between tumor cell death mechanisms and immune system activation. Hence, in this review, we summarize knowledge of the reciprocal interaction between antitumor immunity and distinct cell death mechanisms, particularly necroptosis, ferroptosis, and pyroptosis, which are the three potentially novel mechanisms of immunogenic cell death. Because most evidence is derived from studies using animal and cell models, we also reviewed related bioinformatics data available for human tissues in public databases, which partially confirmed the presence of interactions between tumor cell death and the activation of antitumor immunity.
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Keywords {🔍}

pubmed, cells, cell, google, scholar, cancer, cas, ferroptosis, tumor, pyroptosis, death, central, immunity, necroptosis, immune, wang, antitumor, anticancer, liu, induce, zhang, studies, activation, icis, icd, necroptotic, immunotherapy, expression, chen, induction, release, immunogenic, patients, apoptosis, reported, med, biol, therapy, nat, role, caspase, mice, drugs, msi, tmb, tang, jiang, protein, lipid, cancers,

Topics {✒️}

dpp8/dpp9 inhibitor-induced pyroptosis pro-interleukin-1β protein complexes activated macrophage-derived il-1β radiotherapy-activated ataxia-telangiectasia mutated friedmann angeli jp regulating pro-ferroptotic lipid nlrp3/asc/caspase-1/gsdmd axis cell-derived ifn-γ increases thought-provoking question relates activating anti-tumour immunity shanghai rising-star program decoupling nf-κb signaling pd1/pdl-1 inhibitors exert pyroptosis-initiated tumor killing nf-κb-derived signals inflammatory anti-microbial response perform pro-tumor functions ripk1-ripk3-mlkl signaling complex biomaterial-assisted targeted modulation ripk3-mixed lineage kinase immune-mediated tumor control sensitize/desensitize tumor cells cell-mediated tumor control tumor-infiltrating immune cells small-cell lung cancer bravo-san pedro jm autophagy-dependent cell death myeloid-derived suppressor cells nf-κb-induced transcription single-dose radiotherapy induces necrosis-induced inflammation facilitates mouse-derived tumor cells nutrient-deprived cancer cells pd-l1 inhibitor treatment reduced cancer-related mortality tailored immune-stimulatory modality rna sequencing-based studies neoantigen-based cancer immunotherapy gsdme-dependent activation regulated death-inducing signaling complex ici-activated anticancer immunity vaccination-induced tumor regression xc-complex imports cystine ifn-γ-mediated downregulation immune-mediated abscopal effect cytolytic pore-forming protein cancer-acquired drug resistance article download pdf polyunsaturated fatty acids platinum-based drug results

Questions {❓}

T cell-tumor cell: a fatal interaction?
The role of pyroptosis in cancer: pro-cancer or pro-“host”?

Schema {🗺️}

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