
NCBI . NLM . NIH . GOV {
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Title[redir]:
Alzheimer's Disease: Targeting the Cholinergic System - PMC
Description:
Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl-CoA and choline in the cytoplasm and the vesicular acetylcholine ...
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Keywords {🔍}
doi, pubmed, google, scholar, cholinergic, receptors, acetylcholine, choline, disease, pmc, neurons, nicotinic, article, free, ach, muscarinic, alzheimers, receptor, brain, synaptic, neurosci, memory, transporter, nucleus, rat, patients, neuronal, protein, system, cortex, acetyltransferase, cognitive, res, chat, cns, ache, presynaptic, cht, amyloid, vesicular, demonstrated, neurol, basal, human, dementia, release, jneurosci, biol, vesicles, loss,
Topics {✒️}
n-methyl-d-aspartate receptors facilitate n-methyl-d-aspartate hypothalamic-pituitary-adrenal 1-dimethyl-4-phenylpiperazinium hypothalamo-pituitary-adrenal axis tone/shock-induced fear conditioning reverse amphetamine-induced hyperlocomotion β-amyloid peptides membrane-bound choline-o-acetyltransferase nerve growth factor beta-amyloid precursor protein high-affinity choline transporter post-ganglionic parasympathetic neurons post-ganglionic sympathetic neurons attentional task-performing tests [3h]hemicholinium-3 binding sites pmc beta search amyloid-beta attenuates alzheimer-disease hc-3-sensitive amyloid precursor protein subtype-selective allosteric modulators m1/g-protein uncoupling β-amyloid plaques choline ester-splitting enzymes intra-hippocampal scopolamine injections double-blind study designed attentional task-performing rats normal long-term potentiation central nervous system shortand long-term effect subcortico-cortical cholinergic system putative vesicular transporter ligand-gated ion channels guinea-pig cerebral cortex vesicular acetylcholine transporter m1-selective allosteric agonist amyloid beta peptide beta-amyloid peptide central nervous systems nmda receptor antagonist cerebrovascular amyloid protein vesicular transporter activity long-term memory processes modulating dopamine-dependent behaviors caudate-putamen complex proper presynaptic nerve terminal muscarinic-mediated inhibition occurs national population-based study dmpp long-lasting modulatory effects
Questions {❓}
- A turning point for therapy?
- Do cholinesterase inhibitors act primarily on attention deficit?
- Neuropsychiatric symptoms in Alzheimer’s disease: What might be associated brain circuits?
- “Is dopamine involved in Alzheimer’s disease?
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- How much cash flow does https://scholar.google.com/scholar_lookup?journal=J.%20Neurochem.&title=Regulation%20of%20acetylcholine%20synthesis%20in%20the%20brain.&author=S.%20Tucek&volume=44&issue=1&publication_year=1985&pages=11-24&pmid=3880580&doi=10.1111/j.1471-4159.1985.tb07106.x& have monthly?
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- https://scholar.google.com/scholar_lookup?journal=Neurosci.%20Lett.&title=Distribution%20of%20the%20high-affinity%20choline%20transporter%20in%20the%20human%20and%20macaque%20monkey%20spinal%20cord.&author=Y.%20Kobayashi&author=T.%20Okuda&author=Y.%20Fujioka&author=G.%20Matsumura&author=Y.%20Nishimura&volume=317&issue=1&publication_year=2002&pages=25-28&pmid=11750988&doi=10.1016/S0304-3940(01)02413-2&'s revenue stream
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- https://scholar.google.com/scholar_lookup?journal=J.%20Neurochem.&title=The%20hemicholinium-3%20sensitive%20high%20affinity%20choline%20transporter%20is%20internalized%20by%20clathrin-mediated%20endocytosis%20and%20is%20present%20in%20endosomes%20and%20synaptic%20vesicles.&author=F.M.%20Ribeiro&author=J.%20Alves-Silva&author=W.%20Volknandt&author=C.%20Martins-Silva&author=H.%20Mahmud&volume=87&issue=1&publication_year=2003&pages=136-146&pmid=12969261&doi=10.1046/j.1471-4159.2003.01974.x& income
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- Discover the revenue of https://doi.org/10.1111/j.1471-4159.1981.tb01610.x
- How much does https://scholar.google.com/scholar_lookup?journal=J.%20Neurochem.&title=Effect%20of%20increasing%20choline,%20in%20vivo%20and%20in%20vitro,%20on%20the%20synthesis%20of%20acetylcholine%20in%20a%20sympathetic%20ganglion.&author=S.%20O%E2%80%99Regan&author=B.%20Collier&volume=36&issue=2&publication_year=1981&pages=420-430&pmid=7463070&doi=10.1111/j.1471-4159.1981.tb01610.x& rake in every month?
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- How much revenue does https://doi.org/10.1523/JNEUROSCI.03-01-00001.1983 produce monthly?
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- What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Brain%20Res.%20Bull.&title=Cholinergic%20neurons%20in%20the%20caudate-putamen%20complex%20proper%20are%20intrinsically%20organized:%20a%20combined%20Evans%20blue%20and%20acetylcholinesterase%20analysis.&author=N.J.%20Woolf&author=L.L.%20Butcher&volume=7&issue=5&publication_year=1981&pages=487-507&pmid=7317794&doi=10.1016/0361-9230(81)90004-6&?
- What's https://doi.org/10.1016/0306-4522(84)90165-9's gross income?
- How much profit is https://scholar.google.com/scholar_lookup?journal=Neuroscience&title=Characterization%20of%20cholinergic%20neurons%20in%20the%20rat%20neostriatum.%20A%20combination%20of%20choline%20acetyltransferase%20immunocytochemistry,%20Golgi-impregnation%20and%20electron%20microscopy.&author=J.P.%20Bolam&author=B.H.%20Wainer&author=A.D.%20Smith&volume=12&issue=3&publication_year=1984&pages=711-718&pmid=6382048&doi=10.1016/0306-4522(84)90165-9& making per month?
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- How much does https://scholar.google.com/scholar_lookup?journal=J.%20Comp.%20Neurol.&title=Cholinergic%20innervation%20of%20cortex%20by%20the%20basal%20forebrain:%20cytochemistry%20and%20cortical%20connections%20of%20the%20septal%20area,%20diagonal%20band%20nuclei,%20nucleus%20basalis%20(substantia%20innominata),%20and%20hypothalamus%20in%20the%20rhesus%20monkey.&author=M.M.%20Mesulam&author=E.J.%20Mufson&author=A.I.%20Levey&author=B.H.%20Wainer&volume=214&issue=2&publication_year=1983&pages=170-197&pmid=6841683&doi=10.1002/cne.902140206& pull in?
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- Income figures for https://scholar.google.com/scholar_lookup?journal=Trends%20Neurosci.&title=A%20reappraisal%20of%20the%20functions%20of%20the%20nucleus%20basalis%20of%20Meynert.&author=R.T.%20Richardson&author=M.R.%20DeLong&volume=11&issue=6&publication_year=1988&pages=264-267&pmid=2465623&doi=10.1016/0166-2236(88)90107-5&
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- How much income does https://scholar.google.com/scholar_lookup?journal=Annu.%20Rev.%20Psychol.&title=Central%20cholinergic%20systems%20and%20cognition.&author=B.J.%20Everitt&author=T.W.%20Robbins&volume=48&publication_year=1997&pages=649-684&pmid=9046571&doi=10.1146/annurev.psych.48.1.649& have?
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- How much cash flow does https://doi.org/10.1016/S0079-6123(03)45011-5 have monthly?
- Discover the revenue of https://doi.org/10.1002/cne.902590403
- Check the income stats for https://scholar.google.com/scholar_lookup?journal=J.%20Comp.%20Neurol.&title=Pedunculopontine%20tegmental%20nucleus%20of%20the%20rat:%20cytoarchitecture,%20cytochemistry,%20and%20some%20extrapyramidal%20connections%20of%20the%20mesopontine%20tegmentum.&author=D.B.%20Rye&author=C.B.%20Saper&author=H.J.%20Lee&author=B.H.%20Wainer&volume=259&issue=4&publication_year=1987&pages=483-528&pmid=2885347&doi=10.1002/cne.902590403&
- What's the revenue for https://doi.org/10.1126/science.1094539?
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- How much revenue does https://scholar.google.com/scholar_lookup?journal=J.%20Cell%20Biol.&title=Three-dimensional%20structure%20of%20the%20acetylcholine%20receptor%20by%20cryoelectron%20microscopy%20and%20helical%20image%20reconstruction.&author=C.%20Toyoshima&author=N.%20Unwin&volume=111&issue=6%20Pt%201&publication_year=1990&pages=2623-2635&pmid=2277076&doi=10.1083/jcb.111.6.2623& bring in?
- How much money does https://doi.org/10.1038/315474a0 make?
- What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Nature&title=Quaternary%20structure%20of%20the%20acetylcholine%20receptor.&author=A.%20Brisson&author=P.N.%20Unwin&volume=315&issue=6019&publication_year=1985&pages=474-477&pmid=4000275&doi=10.1038/315474a0&?
- Income figures for https://doi.org/10.1083/jcb.99.4.1202
- How much does https://doi.org/10.1038/350235a0 pull in monthly?
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Nature&title=Pentameric%20structure%20and%20subunit%20stoichiometry%20of%20a%20neuronal%20nicotinic%20acetylcholine%20receptor.&author=E.%20Cooper&author=S.%20Couturier&author=M.%20Ballivet&volume=350&issue=6315&publication_year=1991&pages=235-238&pmid=2005979&doi=10.1038/350235a0&?
- Discover the revenue of https://doi.org/10.1124/mol.63.2.311
- Earnings of https://scholar.google.com/scholar_lookup?journal=Mol.%20Pharmacol.&title=Relating%20neuronal%20nicotinic%20acetylcholine%20receptor%20subtypes%20defined%20by%20subunit%20composition%20and%20channel%20function.&author=Q.%20Nai&author=J.M.%20McIntosh&author=J.F.%20Margiotta&volume=63&issue=2&publication_year=2003&pages=311-324&pmid=12527802&doi=10.1124/mol.63.2.311&
- Income figures for https://doi.org/10.1523/JNEUROSCI.13-02-00596.1993
- How much profit does https://scholar.google.com/scholar_lookup?journal=J.%20Neurosci.&title=Molecular%20cloning,%20functional%20properties,%20and%20distribution%20of%20rat%20brain%20alpha%207:%20a%20nicotinic%20cation%20channel%20highly%20permeable%20to%20calcium.&author=P.%20S%C3%A9gu%C3%A9la&author=J.%20Wadiche&author=K.%20Dineley-Miller&author=J.A.%20Dani&author=J.W.%20Patrick&volume=13&issue=2&publication_year=1993&pages=596-604&pmid=7678857&doi=10.1523/JNEUROSCI.13-02-00596.1993& generate?
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- How profitable is https://scholar.google.com/scholar_lookup?journal=Neuron&title=Nicotinic%20receptors%20in%20the%20development%20and%20modulation%20of%20CNS%20synapses.&author=L.W.%20Role&author=D.K.%20Berg&volume=16&issue=6&publication_year=1996&pages=1077-1085&pmid=8663984&doi=10.1016/S0896-6273(00)80134-8&?
- https://doi.org/10.1007/BF00965590 income
- What's the profit of https://scholar.google.com/scholar_lookup?journal=Neurochem.%20Res.&title=Subcellular%20fractionation%20and%20distribution%20of%20cholinergic%20binding%20sites%20in%20fetal%20human%20brain.&author=J.%20Whyte&author=R.%20Harrison&author=G.G.%20Lunt&author=S.%20Wonnacott&volume=11&issue=7&publication_year=1986&pages=1011-1023&pmid=3748272&doi=10.1007/BF00965590&?
- How much money does https://doi.org/10.1523/JNEUROSCI.18-18-07075.1998 make?
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- Get to know https://doi.org/10.1038/383713a0's earnings
- How profitable is https://scholar.google.com/scholar_lookup?journal=Nature&title=Hippocampal%20synaptic%20transmission%20enhanced%20by%20low%20concentrations%20of%20nicotine.&author=R.%20Gray&author=A.S.%20Rajan&author=K.A.%20Radcliffe&author=M.%20Yakehiro&author=J.A.%20Dani&volume=383&issue=6602&publication_year=1996&pages=713-716&pmid=8878480&doi=10.1038/383713a0&?
- What's the monthly income of https://doi.org/10.1111/j.1749-6632.1999.tb11332.x?
- How much does https://scholar.google.com/scholar_lookup?journal=Ann.%20N.%20Y.%20Acad.%20Sci.&title=Nicotinic%20modulation%20of%20glutamate%20and%20GABA%20synaptic%20transmission%20of%20hippocampal%20neurons.&author=K.A.%20Radcliffe&author=J.L.%20Fisher&author=R.%20Gray&author=J.A.%20Dani&volume=868&publication_year=1999&pages=591-610&pmid=10414340&doi=10.1111/j.1749-6632.1999.tb11332.x& net monthly?
- How profitable is https://doi.org/10.1126/science.7569895?
- Financial intake of https://scholar.google.com/scholar_lookup?journal=Science&title=Nicotine%20enhancement%20of%20fast%20excitatory%20synaptic%20transmission%20in%20CNS%20by%20presynaptic%20receptors.&author=D.S.%20McGehee&author=M.J.%20Heath&author=S.%20Gelber&author=P.%20Devay&author=L.W.%20Role&volume=269&issue=5231&publication_year=1995&pages=1692-1696&pmid=7569895&doi=10.1126/science.7569895&
- What's the income generated by https://doi.org/10.1007/BF02532425 each month?
- Get to know https://scholar.google.com/scholar_lookup?journal=Neurochem.%20Res.&title=Pharmacological%20characterization%20of%20a%20nicotinic%20autoreceptor%20in%20rat%20hippocampal%20synaptosomes.&author=G.I.%20Wilkie&author=P.%20Hutson&author=J.P.%20Sullivan&author=S.%20Wonnacott&volume=21&issue=9&publication_year=1996&pages=1141-1148&pmid=8897478&doi=10.1007/BF02532425&'s earnings
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- How much does https://scholar.google.com/scholar_lookup?journal=Br.%20J.%20Pharmacol.&title=Release%20of%20%5B3H%5D-noradrenaline%20from%20rat%20hippocampal%20synaptosomes%20by%20nicotine:%20mediation%20by%20different%20nicotinic%20receptor%20subtypes%20from%20striatal%20%5B3H%5D-dopamine%20release.&author=P.B.%20Clarke&author=M.%20Reuben&volume=117&issue=4&publication_year=1996&pages=595-606&pmid=8646402&doi=10.1111/j.1476-5381.1996.tb15232.x& earn?
- https://doi.org/10.1002/syn.890160105's financial summary
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- How much does https://scholar.google.com/scholar_lookup?journal=Curr.%20Drug%20Targets%20CNS%20Neurol.%20Disord.&title=The%20role%20of%20neuronal%20nicotinic%20acetylcholine%20receptors%20in%20acute%20and%20chronic%20neurodegeneration.&author=M.J.%20O%E2%80%99Neill&author=T.K.%20Murray&author=V.%20Lakics&author=N.P.%20Visanji&author=S.%20Duty&volume=1&issue=4&publication_year=2002&pages=399-411&pmid=12769612&doi=10.2174/1568007023339166& net monthly?
- How much does https://doi.org/10.1046/j.1471-4159.1997.69062427.x gross monthly?
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- What are the total earnings of https://doi.org/10.1523/JNEUROSCI.11-03-00837.1991?
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- How much does https://scholar.google.com/scholar_lookup?journal=J.%20Pharmacol.%20Exp.%20Ther.&title=Pharmacological%20characterization%20of%20recombinant%20human%20neuronal%20nicotinic%20acetylcholine%20receptors%20h%20alpha%202%20beta%202,%20h%20alpha%202%20beta%204,%20h%20alpha%203%20beta%202,%20h%20alpha%203%20beta%204,%20h%20alpha%204%20beta%202,%20h%20alpha%204%20beta%204%20and%20h%20alpha%207%20expressed%20in%20Xenopus%20oocytes.&author=L.E.%20Chavez-Noriega&author=J.H.%20Crona&author=M.S.%20Washburn&author=A.%20Urrutia&author=K.J.%20Elliott&volume=280&issue=1&publication_year=1997&pages=346-356&pmid=8996215& net monthly?
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- See how much https://doi.org/10.1113/jphysiol.1971.sp009467 makes per month
- Check the income stats for https://scholar.google.com/scholar_lookup?journal=J.%20Physiol.&title=The%20mechanism%20of%20excitation%20by%20acetylcholine%20in%20the%20cerebral%20cortex.&author=K.%20Krnjevi%C4%87&author=R.%20Pumain&author=L.%20Renaud&volume=215&issue=1&publication_year=1971&pages=247-268&pmid=5579661&doi=10.1113/jphysiol.1971.sp009467&
- What are the total earnings of https://doi.org/10.1113/jphysiol.1985.sp015777?
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=J.%20Physiol.&title=Membrane%20currents%20underlying%20the%20cholinergic%20slow%20excitatory%20post-synaptic%20potential%20in%20the%20rat%20sympathetic%20ganglion.&author=D.A.%20Brown&author=A.A.%20Selyanko&volume=365&publication_year=1985&pages=365-387&pmid=2411921&doi=10.1113/jphysiol.1985.sp015777&?
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- What is the earnings of https://doi.org/10.1523/JNEUROSCI.11-10-03218.1991?
- Income figures for https://scholar.google.com/scholar_lookup?journal=J.%20Neurosci.&title=Identification%20and%20localization%20of%20muscarinic%20acetylcholine%20receptor%20proteins%20in%20brain%20with%20subtype-specific%20antibodies.&author=A.I.%20Levey&author=C.A.%20Kitt&author=W.F.%20Simonds&author=D.L.%20Price&author=M.R.%20Brann&volume=11&issue=10&publication_year=1991&pages=3218-3226&pmid=1941081&doi=10.1523/JNEUROSCI.11-10-03218.1991&
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- How much revenue does https://scholar.google.com/scholar_lookup?journal=Brain%20Res.&title=M1%20muscarinic%20receptor%20signaling%20in%20mouse%20hippocampus%20and%20cortex.&author=A.C.%20Porter&author=F.P.%20Bymaster&author=N.W.%20DeLapp&author=M.%20Yamada&author=J.%20Wess&volume=944&issue=1-2&publication_year=2002&pages=82-89&pmid=12106668&doi=10.1016/S0006-8993(02)02721-X& generate?
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- How much income does https://doi.org/10.1523/JNEUROSCI.07-03-00733.1987 have?
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- What's the profit of https://doi.org/10.1016/0014-4886(78)90284-4?
- https://scholar.google.com/scholar_lookup?journal=Exp.%20Neurol.&title=Presynaptic%20inhibitory%20action%20of%20acetylcholine%20in%20area%20CA1%20of%20the%20hippocampus.&author=J.%20Hounsgaard&volume=62&issue=3&publication_year=1978&pages=787-797&pmid=750222&doi=10.1016/0014-4886(78)90284-4&'s total income per month
- Revenue of https://doi.org/10.1152/jn.1983.50.6.1249
- What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=J.%20Neurophysiol.&title=Rat%20hippocampal%20neurons%20in%20culture:%20responses%20to%20electrical%20and%20chemical%20stimuli.&author=M.%20Segal&volume=50&issue=6&publication_year=1983&pages=1249-1264&pmid=6663325&doi=10.1152/jn.1983.50.6.1249&?
- Profit of https://doi.org/10.1113/jphysiol.1992.sp019015
- Discover the revenue of https://scholar.google.com/scholar_lookup?journal=J.%20Physiol.&title=The%20inositol%201,4,5-trisphosphate%20pathway%20mediates%20cholinergic%20potentiation%20of%20rat%20hippocampal%20neuronal%20responses%20to%20NMDA.&author=H.%20Markram&author=M.%20Segal&volume=447&publication_year=1992&pages=513-533&pmid=1593457&doi=10.1113/jphysiol.1992.sp019015&
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- How much revenue does https://scholar.google.com/scholar_lookup?journal=J.%20Physiol.&title=Mechanisms%20of%20action%20of%20acetylcholine%20in%20the%20guinea-pig%20cerebral%20cortex%20in%20vitro.&author=D.A.%20McCormick&author=D.A.%20Prince&volume=375&publication_year=1986&pages=169-194&pmid=2879035&doi=10.1113/jphysiol.1986.sp016112& produce monthly?
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- https://doi.org/10.1016/0304-3940(87)90419-8's revenue stream
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Neurosci.%20Lett.&title=Muscarine%20affects%20calcium-currents%20in%20rat%20hippocampal%20pyramidal%20cells%20in%20vitro.&author=B.H.%20G%C3%A4hwiler&author=D.A.%20Brown&volume=76&issue=3&publication_year=1987&pages=301-306&pmid=3587761&doi=10.1016/0304-3940(87)90419-8&?
- Discover the revenue of https://doi.org/10.1016/S0024-3205(97)00049-0
- How much profit is https://scholar.google.com/scholar_lookup?journal=Life%20Sci.&title=Muscarinic%20receptor%20subtype%20selective%20toxins.&author=A.%20Adem&author=E.%20Karlsson&volume=60&issue=13-14&publication_year=1997&pages=1069-1076&pmid=9121349&doi=10.1016/S0024-3205(97)00049-0& making per month?
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- How much cash flow does https://scholar.google.com/scholar_lookup?journal=J.%20Neurol.%20Sci.&title=Alzheimer%E2%80%99s%20disease.%20Correlation%20of%20cortical%20choline%20acetyltransferase%20activity%20with%20the%20severity%20of%20dementia%20and%20histological%20abnormalities.&author=G.K.%20Wilcock&author=M.M.%20Esiri&author=D.M.%20Bowen&author=C.C.%20Smith&volume=57&issue=2-3&publication_year=1982&pages=407-417&pmid=7161627&doi=10.1016/0022-510X(82)90045-4& have monthly?
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- Profit of https://doi.org/10.1006/exnr.2000.7397
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- https://doi.org/10.1007/BF00229886's financial summary
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- Revenue of https://github.com/ncbi
- Financial intake of https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323
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Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi