
NCBI . NLM . NIH . GOV {
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Title[redir]:
Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer’s disease - PMC
Description:
Trimethylamine-N-oxide (TMAO), a metabolite of gut microbiota, has been implicated in the pathogenesis of Alzheimer’s disease (AD). However, the mechanisms by which TMAO influence cognitive and pathological processes in the AD have not been ...
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Keywords {🔍}
mice, appps, tmao, levels, doi, pubmed, google, scholar, figure, plasma, hippocampus, clusterin, pmc, test, article, dmb, free, cognitive, disease, monthold, versus, means, object, alzheimers, ltp, analysis, results, group, significantly, age, memory, pathological, study, circulating, treatment, concentration, showed, supplementary, behavioral, brain, platelet, recognition, testing, data, syngeneic, mouse, agerelated, βsecretase, βctf, months,
Topics {✒️}
including n-methyl-d-aspartate receptors β-secretase-cleaved c-terminal fragment granulocyte-macrophage colony-stimulating factor β-secretase c-terminal fragment granulocyte colony-stimulating factor understanding brain-gut-microbiome connections mouse anti-β-amyloid antibody circulating trimethylamine-n-oxide trimethylamine n-oxide metabolism sil-20axr autosampler attached pmc beta search pre-determined measuring scale dmb-treated app/ps1 mice amyloid-beta aggregation pathway app/ps1 mice exhibited stimulus-selective response plasticity trimethylamine-n-oxide trimethylamine n-oxide app/ps1 group exhibited enzyme-linked immunosorbent assay constant stimulus-response curve macrophage inflammatory protein-1β multiplex bead analysis app/ps1 mice developed untreated app/ps1 mice age-matched control littermates gut microbial metabolites app/ps1 mice displayed app/ps1 mice treated treated app/ps1 mice age-matched nontransgenic littermates app/ps1 mice characterized app/ps1 transgenic mice clusterin-knockout pdapp mice 5-μm-thick tissue slices app/ps1 mice based app/ps1 mice compared app/ps1+ nt mice β-secretase cut app multiplex map kit increases long-term potentiation ifnγ means interferon-γ app/ps1+dmb mice pre-activated blood platelets macrophage scavenger receptors nissl body numbers app/ps1 mice platelets cambridge isotope laboratories meta-organismal metabolite amyloid precursor protein
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