
NCBI . NLM . NIH . GOV {
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Title[redir]:
The Role of Non-coding RNAs in Oncology - PMC
Description:
For decades, research into cancer biology focused on the involvement of protein-coding genes. Only recently was it discovered that an entire class of molecules, termed non-coding RNA (ncRNA), plays key regulatory roles in shaping cellular activity. ...
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Keywords {🔍}
cancer, doi, scholar, pubmed, google, pmc, article, free, rna, cell, tumor, noncoding, lncrna, ncrnas, mirna, expression, mouse, rnas, mirnas, prostate, long, prognostic, wang, proliferation, lung, slack, lncrnas, genes, zhang, patients, nat, oncogenic, tissue, target, overexpression, microrna, breast, xenografts, liu, ncrna, res, clinical, human, cells, small, blood, therapeutic, targeting, levels, metastasis,
Topics {✒️}
sphk1/akt/nf-kappab signaling dleu2/mir-15a/16–1 cluster controls microrna-21-induced pre-b-cell lymphoma trna-derived stress-induced rnas mir-34a silences c-src multi-institutional high-throughput analysis wnt/p-catenin target genes binds/inhibits nf-kb pmc beta search k-ras-dependent lung tumorigenesis wnt/β-catenin signaling mir-506-induced epithelial-mesenchymal transition adult t-cell leukemia/lymphoma p53-inducible lincrna essential antigen peptide-loading complexes nf-kb/ikb complex transfer rna-related fragments pten-regulating microrna mir-26a castration-resistant prostate cancer tgf-beta pathway genes therapeutically resistant k-ras monoclonal b-cell lymphocytosis multi-institutional analysis shows nf-ya transcription factors trna-derived rna fragments trna-derived small rnas dead-box rna helicase hematopoietic cell-specific phosphatase promotes cell-cycle progression super-enhancer-driven ccat1 intact p53-dependent responses activation-induced cell death dartmouth-hitchcock medical center rna-induced silencing complex references adams bd multi-site clinical trial gram quantity small-molecules mir-10b inhibits metastasis aggressive b-cell lymphoma p53-induced mouse model egfr-expressing cancer cells rna-dna triplex structures progression-free survival cutaneous t-cell lymphoma small double-stranded rnas alfred taubman scholar exhibit context-dependent roles liposomal mir-34a mimic microrna-10b expression correlates single-stranded antisense rnas
Questions {❓}
- Is miR-29 an oncogene or tumor suppressor in CLL?
- Large non-coding RNAs: missing links in cancer?
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- What are the earnings of https://scholar.google.com/scholar_lookup?journal=Cancer%20Cell&title=Hacking%20the%20cancer%20genome:%20profiling%20therapeutically%20actionable%20long%20non-coding%20RNAs%20using%20CRISPR-Cas9%20screening&author=R%20Esposito&author=N%20Bosch&author=A%20Lanzos&author=T%20Polidori&author=C%20Pulido-Quetglas&volume=35&publication_year=2019&pages=545-557&pmid=30827888&doi=10.1016/j.ccell.2019.01.019&?
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- What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Genome%20Res&title=Most%20mammalian%20mRNAs%20are%20conserved%20targets%20of%20microRNAs&author=RC%20Friedman&author=KK%20Farh&author=CB%20Burge&author=DP%20Bartel&volume=19&publication_year=2009&pages=92-105&pmid=18955434&doi=10.1101/gr.082701.108&?
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- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Carcinogenesis&title=miR-34a%20as%20a%20prognostic%20marker%20of%20relapse%20in%20surgically%20resected%20non-small-cell%20lung%20cancer&author=E%20Gallardo&author=A%20Navarro&author=N%20Vinolas&author=RM%20Marrades&author=T%20Diaz&volume=30&publication_year=2009&pages=1903-1909&pmid=19736307&doi=10.1093/carcin/bgp219&?
- Earnings of https://doi.org/10.1182/blood-2009-03-211938
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- How much revenue does https://doi.org/10.1038/nature11245 produce monthly?
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- How much does https://doi.org/10.1158/1078-0432.CCR-17-2733 bring in each month?
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- What's the income generated by https://doi.org/10.1038/nature04917 each month?
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- Income figures for https://doi.org/10.1016/j.juro.2013.12.011
- https://scholar.google.com/scholar_lookup?journal=J%20Urol&title=DNA%20based%20therapy%20with%20diphtheria%20toxin-A%20BC-819:%20a%20phase%202b%20marker%20lesion%20trial%20in%20patients%20with%20intermediate%20risk%20nonmuscle%20invasive%20bladder%20cancer&author=ON%20Gofrit&author=S%20Benjamin&author=S%20Halachmi&author=I%20Leibovitch&author=Z%20Dotan&volume=191&publication_year=2014&pages=1697-1702&pmid=24342146&doi=10.1016/j.juro.2013.12.011&'s total income per month
- How much money does https://doi.org/10.1016/j.cell.2015.02.053 generate?
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- What is the earnings of https://doi.org/10.1158/0008-5472.CAN-05-0298?
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- Monthly income for https://doi.org/10.1158/0008-5472.CAN-12-2850
- https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=The%20noncoding%20RNA%20MALAT1%20is%20a%20critical%20regulator%20of%20the%20metastasis%20phenotype%20of%20lung%20cancer%20cells&author=T%20Gutschner&author=M%20Hammerle&author=M%20Eissmann&author=J%20Hsu&author=Y%20Kim&volume=73&publication_year=2013&pages=1180-1189&pmid=23243023&doi=10.1158/0008-5472.CAN-12-2850& income
- How much profit does https://doi.org/10.1016/j.ccr.2010.08.013 make?
- How much does https://scholar.google.com/scholar_lookup?journal=Cancer%20Cell&title=Modulation%20of%20K-Ras-dependent%20lung%20tumorigenesis%20by%20MicroRNA-21&author=ME%20Hatley&author=DM%20Patrick&author=MR%20Garcia&author=JA%20Richardson&author=R%20Bassel-Duby&volume=18&publication_year=2010&pages=282-293&pmid=20832755&doi=10.1016/j.ccr.2010.08.013& bring in each month?
- What's https://doi.org/10.1016/s0302-2838(03)00201-x's gross income?
- What's the profit of https://scholar.google.com/scholar_lookup?journal=Eur%20Urol&title=DD3(PCA3)-based%20molecular%20urine%20analysis%20for%20the%20diagnosis%20of%20prostate%20cancer&author=D%20Hessels&author=JM%20Klein%20Gunnewiek&author=I%20van%20Oort&author=HF%20Karthaus&author=GJ%20van%20Leenders&volume=44&publication_year=2003&pages=8-15&pmid=12814669&doi=10.1016/s0302-2838(03)00201-x&?
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- What is the monthly revenue of https://doi.org/10.1016/j.cell.2017.11.040?
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- What's the profit of https://doi.org/10.1158/0008-5472.CAN-16-1883?
- See how much https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Noncoding%20effects%20of%20circular%20RNA%20CCDC66%20promote%20colon%20cancer%20growth%20and%20metastasis&author=KY%20Hsiao&author=YC%20Lin&author=SK%20Gupta&author=N%20Chang&author=L%20Yen&volume=77&publication_year=2017&pages=2339-2350&pmid=28249903&doi=10.1158/0008-5472.CAN-16-1883& makes per month
- What's the monthly income of https://doi.org/10.1172/JCI63539?
- See how much https://scholar.google.com/scholar_lookup?journal=J%20Clin%20Invest&title=Essential%20metabolic,%20anti-inflammatory,%20and%20anti-tumorigenic%20functions%20of%20miR-122%20in%20liver&author=SH%20Hsu&author=B%20Wang&author=J%20Kota&author=J%20Yu&author=S%20Costinean&volume=122&publication_year=2012&pages=2871-2883&pmid=22820288&doi=10.1172/JCI63539& makes per month
- Check the income stats for https://doi.org/10.1038/s41590-019-0400-7
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- See how much https://doi.org/10.1016/j.ccr.2014.07.009 makes per month
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- How much income does https://doi.org/10.1093/mutage/gew018 have?
- How much income does https://scholar.google.com/scholar_lookup?journal=Mutagenesis&title=Genetic%20variants%20in%20lncRNA%20H19%20are%20associated%20with%20the%20risk%20of%20bladder%20cancer%20in%20a%20Chinese%20population&author=Q%20Hua&author=X%20Lv&author=X%20Gu&author=Y%20Chen&author=H%20Chu&volume=31&publication_year=2016&pages=531-538&pmid=27091055&doi=10.1093/mutage/gew018& have?
- https://doi.org/10.1038/s41590-018-0207-y's total income per month
- What are the earnings of https://scholar.google.com/scholar_lookup?journal=Nat%20Immunol&title=NKILA%20lncRNA%20promotes%20tumor%20immune%20evasion%20by%20sensitizing%20T%20cells%20to%20activation-induced%20cell%20death&author=D%20Huang&author=J%20Chen&author=L%20Yang&author=Q%20Ouyang&author=J%20Li&volume=19&publication_year=2018&pages=1112-1125&pmid=30224822&doi=10.1038/s41590-018-0207-y&?
- How much money does https://doi.org/10.1016/j.eururo.2014.07.035 generate?
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- https://doi.org/10.1093/hmg/ddq353's total income per month
- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Hum%20Mol%20Genet&title=Large%20non-coding%20RNAs:%20missing%20links%20in%20cancer&author=M%20Huarte&author=JL%20Rinn&volume=19&publication_year=2010&pages=R152-161&pmid=20729297&doi=10.1093/hmg/ddq353&?
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- Earnings of https://scholar.google.com/scholar_lookup?journal=Nat%20Commun&title=Conserved%20sequence-specific%20lincRNA-steroid%20receptor%20interactions%20drive%20transcriptional%20repression%20and%20direct%20cell%20fate&author=WH%20Hudson&author=MR%20Pickard&author=IM%20de%20Vera&author=EG%20Kuiper&author=M%20Mourtada-Maarabouni&volume=5&publication_year=2014&pages=5395&pmid=25377354&doi=10.1038/ncomms6395&
- What's the financial intake of https://doi.org/10.1073/pnas.1415669112?
- Profit of https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20USA&title=A%20long%20noncoding%20RNA%20connects%20c-Myc%20to%20tumor%20metabolism&author=CL%20Hung&author=LY%20Wang&author=YL%20Yu&author=HW%20Chen&author=S%20Srivastava&volume=111&publication_year=2014&pages=18697-18702&pmid=25512540&doi=10.1073/pnas.1415669112&
- https://doi.org/10.1038/ng.848's financial summary
- How much profit does https://scholar.google.com/scholar_lookup?journal=Nat%20Genet&title=Extensive%20and%20coordinated%20transcription%20of%20noncoding%20RNAs%20within%20cell-cycle%20promoters&author=T%20Hung&author=Y%20Wang&author=MF%20Lin&author=AK%20Koegel&author=Y%20Kotake&volume=43&publication_year=2011&pages=621-629&pmid=21642992&doi=10.1038/ng.848& make?
- Get to know https://doi.org/10.1101/gad.1777409's earnings
- How much does https://scholar.google.com/scholar_lookup?journal=Genes%20Dev&title=The%20PTEN-regulating%20microRNA%20miR-26a%20is%20amplified%20in%20high-grade%20glioma%20and%20facilitates%20gliomagenesis%20in%20vivo&author=JT%20Huse&author=C%20Brennan&author=D%20Hambardzumyan&author=B%20Wee&author=J%20Pena&volume=23&publication_year=2009&pages=1327-1337&pmid=19487573&doi=10.1101/gad.1777409& generate monthly?
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- How profitable is https://scholar.google.com/scholar_lookup?journal=Ann%20Oncol&title=Circulating%20microRNA-1290%20as%20a%20novel%20diagnostic%20and%20prognostic%20biomarker%20in%20human%20colorectal%20cancer&author=H%20Imaoka&author=Y%20Toiyama&author=H%20Fujikawa&author=J%20Hiro&author=S%20Saigusa&volume=27&publication_year=2016&pages=1879-1886&pmid=27502702&doi=10.1093/annonc/mdw279&?
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- How much profit is https://scholar.google.com/scholar_lookup?journal=Cell%20Rep&title=Analysis%20of%20intron%20sequences%20reveals%20hallmarks%20of%20circular%20RNA%20biogenesis%20in%20animals&author=A%20Ivanov&author=S%20Memczak&author=E%20Wyler&author=F%20Torti&author=HT%20Porath&volume=10&publication_year=2015&pages=170-177&pmid=25558066&doi=10.1016/j.celrep.2014.12.019& making per month?
- Earnings of https://doi.org/10.1038/ng.3192
- What is the earnings of https://scholar.google.com/scholar_lookup?journal=Nat%20Genet&title=The%20landscape%20of%20long%20noncoding%20RNAs%20in%20the%20human%20transcriptome&author=MK%20Iyer&author=YS%20Niknafs&author=R%20Malik&author=U%20Singhal&author=A%20Sahu&volume=47&publication_year=2015&pages=199-208&pmid=25599403&doi=10.1038/ng.3192&?
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- How profitable is https://doi.org/10.1038/s41467-018-06081-9?
- https://scholar.google.com/scholar_lookup?journal=Nat%20Commun&title=Co-activation%20of%20super-enhancer-driven%20CCAT1%20by%20TP63%20and%20SOX2%20promotes%20squamous%20cancer%20progression&author=Y%20Jiang&author=Y-Y%20Jiang&author=J-J%20Xie&author=A%20Mayakonda&author=M%20Hazawa&volume=9&publication_year=2018&pages=3619&pmid=30190462&doi=10.1038/s41467-018-06081-9&'s revenue stream
- How much profit does https://doi.org/10.1158/0008-5472.CAN-07-1083 make?
- How much profit does https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=The%20let-7%20microRNA%20represses%20cell%20proliferation%20pathways%20in%20human%20cells&author=CD%20Johnson&author=A%20Esquela-Kerscher&author=G%20Stefani&author=M%20Byrom&author=K%20Kelnar&volume=67&publication_year=2007&pages=7713-7722&pmid=17699775&doi=10.1158/0008-5472.CAN-07-1083& generate?
- What's the revenue for https://doi.org/10.1016/j.cell.2005.01.014?
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Cell&title=RAS%20is%20regulated%20by%20the%20let-7%20microRNA%20family&author=SM%20Johnson&author=H%20Grosshans&author=J%20Shingara&author=M%20Byrom&author=R%20Jarvis&volume=120&publication_year=2005&pages=635-647&pmid=15766527&doi=10.1016/j.cell.2005.01.014&?
- https://doi.org/10.1016/j.molcel.2013.08.027's financial summary
- How much does https://scholar.google.com/scholar_lookup?journal=Mol%20Cell&title=The%20imprinted%20H19%20lncRNA%20antagonizes%20let-7%20microRNAs&author=AN%20Kallen&author=XB%20Zhou&author=J%20Xu&author=C%20Qiao&author=J%20Ma&volume=52&publication_year=2013&pages=101-112&pmid=24055342&doi=10.1016/j.molcel.2013.08.027& rake in every month?
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- Profit of https://doi.org/10.1038/nrc3166
- Income figures for https://scholar.google.com/scholar_lookup?journal=Nat%20Rev%20Cancer&title=Epigenetics%20and%20genetics.%20MicroRNAs%20en%20route%20to%20the%20clinic:%20progress%20in%20validating%20and%20targeting%20microRNAs%20for%20cancer%20therapy&author=AL%20Kasinski&author=FJ%20Slack&volume=11&publication_year=2011&pages=849-864&pmid=22113163&doi=10.1038/nrc3166&
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- Discover the revenue of https://doi.org/10.1038/onc.2012.193
- Profit of https://scholar.google.com/scholar_lookup?journal=Oncogene&title=HOTAIR%20is%20a%20negative%20prognostic%20factor%20and%20exhibits%20pro-oncogenic%20activity%20in%20pancreatic%20cancer&author=K%20Kim&author=I%20Jutooru&author=G%20Chadalapaka&author=G%20Johnson&author=J%20Frank&volume=32&publication_year=2013&pages=1616-1625&pmid=22614017&doi=10.1038/onc.2012.193&
- How much does https://doi.org/10.1073/pnas.1400350111 earn?
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- Check the income stats for https://scholar.google.com/scholar_lookup?journal=Cancer%20Cell&title=The%20DLEU2/miR-15a/16%E2%80%931%20cluster%20controls%20B%20cell%20proliferation%20and%20its%20deletion%20leads%20to%20chronic%20lymphocytic%20leukemia&author=U%20Klein&author=M%20Lia&author=M%20Crespo&author=R%20Siegel&author=Q%20Shen&volume=17&publication_year=2010&pages=28-40&pmid=20060366&doi=10.1016/j.ccr.2009.11.019&
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- How much profit does https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Long%20noncoding%20RNA%20HOTAIR%20regulates%20polycomb-dependent%20chromatin%20modification%20and%20is%20associated%20with%20poor%20prognosis%20in%20colorectal%20cancers&author=R%20Kogo&author=T%20Shimamura&author=K%20Mimori&author=K%20Kawahara&author=S%20Imoto&volume=71&publication_year=2011&pages=6320-6326&pmid=21862635&doi=10.1158/0008-5472.CAN-11-1021& generate?
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- Explore the financials of https://scholar.google.com/scholar_lookup?journal=Mol%20Cancer&title=Long%20noncoding%20RNA%20PVT1%20indicates%20a%20poor%20prognosis%20of%20gastric%20cancer%20and%20promotes%20cell%20proliferation%20through%20epigenetically%20regulating%20p15%20and%20p16&author=R%20Kong&author=EB%20Zhang&author=DD%20Yin&author=LH%20You&author=TP%20Xu&volume=14&publication_year=2015&pages=82&pmid=25890171&doi=10.1186/s12943-015-0355-8&
- What's the income generated by https://doi.org/10.1016/j.cell.2018.01.011 each month?
- What's https://scholar.google.com/scholar_lookup?journal=Cell&title=Functional%20classification%20and%20experimental%20dissection%20of%20long%20noncoding%20RNAs&author=F%20Kopp&author=JT%20Mendell&volume=172&publication_year=2018&pages=393-407&pmid=29373828&doi=10.1016/j.cell.2018.01.011&'s gross income?
- What is the monthly revenue of https://doi.org/10.1016/j.cell.2009.04.021?
- What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Cell&title=Therapeutic%20microRNA%20delivery%20suppresses%20tumorigenesis%20in%20a%20murine%20liver%20cancer%20model&author=J%20Kota&author=RR%20Chivukula&author=KA%20O%E2%80%99Donnell&author=EA%20Wentzel&author=CL%20Montgomery&volume=137&publication_year=2009&pages=1005-1017&pmid=19524505&doi=10.1016/j.cell.2009.04.021&?
- How much does https://doi.org/10.1093/nar/gky1141 gross monthly?
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- How much income does https://doi.org/10.1261/rna.5980303 have?
- How much revenue does https://scholar.google.com/scholar_lookup?journal=RNA&title=A%20microRNA%20array%20reveals%20extensive%20regulation%20of%20microRNAs%20during%20brain%20development&author=AM%20Krichevsky&author=KS%20King&author=CP%20Donahue&author=K%20Khrapko&author=KS%20Kosik&volume=9&publication_year=2003&pages=1274-1281&pmid=13130141&doi=10.1261/rna.5980303& generate?
- How much money does https://doi.org/10.1038/onc.2017.361 generate?
- Revenue of https://scholar.google.com/scholar_lookup?journal=Oncogene&title=Circular%20RNAs%20in%20cancer:%20opportunities%20and%20challenges%20in%20the%20field&author=LS%20Kristensen&author=TB%20Hansen&author=MT%20Veno&author=J%20Kjems&volume=37&publication_year=2018&pages=555-565&pmid=28991235&doi=10.1038/onc.2017.361&
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- How much profit is https://scholar.google.com/scholar_lookup?journal=Trends%20Biochem%20Sci&title=Biogenesis%20and%20function%20of%20transfer%20RNA-related%20fragments%20(tRFs)&author=P%20Kumar&author=C%20Kuscu&author=A%20Dutta&volume=41&publication_year=2016&pages=679-689&pmid=27263052&doi=10.1016/j.tibs.2016.05.004& making per month?
- How much money does https://doi.org/10.1261/rna.066126.118 generate?
- Financial intake of https://scholar.google.com/scholar_lookup?journal=RNA&title=tRNA%20fragments%20(tRFs)%20guide%20Ago%20to%20regulate%20gene%20expression%20post-transcriptionally%20in%20a%20Dicer-independent%20manner&author=C%20Kuscu&author=P%20Kumar&author=M%20Kiran&author=Z%20Su&author=A%20Malik&volume=24&publication_year=2018&pages=1093-1105&pmid=29844106&doi=10.1261/rna.066126.118&
- See how much https://doi.org/10.1016/0092-8674(93)90529-y makes per month
- What's the income of https://scholar.google.com/scholar_lookup?journal=Cell&title=The%20C.%20elegans%20heterochronic%20gene%20lin-4%20encodes%20small%20RNAs%20with%20antisense%20complementarity%20to%20lin-14&author=RC%20Lee&author=RL%20Feinbaum&author=V%20Ambros&volume=75&publication_year=1993&pages=843-854&pmid=8252621&doi=10.1016/0092-8674(93)90529-y&?
- https://doi.org/10.1101/gad.1837609's revenue stream
- How much does https://scholar.google.com/scholar_lookup?journal=Genes%20Dev&title=A%20novel%20class%20of%20small%20RNAs:%20tRNA-derived%20RNA%20fragments%20(tRFs)&author=YS%20Lee&author=Y%20Shibata&author=A%20Malhotra&author=A%20Dutta&volume=23&publication_year=2009&pages=2639-2649&pmid=19933153&doi=10.1101/gad.1837609& generate monthly?
- How much cash flow does https://doi.org/10.1016/j.molcel.2017.02.017 have monthly?
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- Check the income stats for https://doi.org/10.3389/fgene.2011.00104
- Explore the financials of https://scholar.google.com/scholar_lookup?journal=Front%20Genet&title=MicroRNAs%20-%20important%20molecules%20in%20lung%20cancer%20research&author=P%20Leidinger&author=A%20Keller&author=E%20Meese&volume=2&publication_year=2011&pages=104&pmid=22303398&doi=10.3389/fgene.2011.00104&
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- How profitable is https://doi.org/10.1038/onc.2016.90?
- Get to know what's the income of https://scholar.google.com/scholar_lookup?journal=Oncogene&title=Downregulated%20miR-506%20expression%20facilitates%20pancreatic%20cancer%20progression%20and%20chemoresistance%20via%20SPHK1/Akt/NF-kappaB%20signaling&author=J%20Li&author=H%20Wu&author=W%20Li&author=L%20Yin&author=S%20Guo&volume=35&publication_year=2016a&pages=5501-5514&pmid=27065335&doi=10.1038/onc.2016.90&
- How much revenue does https://doi.org/10.1038/bjc.2013.548 bring in?
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- Learn how profitable https://doi.org/10.1016/j.ccell.2015.02.004 is on a monthly basis
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- Earnings of https://doi.org/10.1038/nm.2284
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- Income figures for https://doi.org/10.1038/srep10423
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