We are analyzing https://link.springer.com/article/10.1007/s00018-017-2458-4.

Title:
The multi-faceted role of retinoid X receptor in bone remodeling | Cellular and Molecular Life Sciences
Description:
Retinoid X receptors (RXRs) form a unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs are obligatory partners for a number of other NRs, placing RXRs in a coordinating role at the crossroads of multiple signaling pathways. In addition, RXRs can function as self-sufficient homodimers. Recent advances have revealed RXRs as novel regulators of osteoclastogenesis and bone remodeling. This review outlines the versatility of RXR action in the control of transcription of bone-forming osteoblasts and bone-resorbing osteoclasts, both through heterodimerization with other NRs and through RXR homodimerization. RXR signaling is currently a major therapeutic target and, therefore, knowledge of how RXR signaling affects bone remodeling creates enormous potential for the translation of basic research findings into successful clinical therapies to increase bone mass and improve bone quality.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Environment

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

pubmed, article, google, scholar, cas, bone, receptor, central, retinoid, receptors, nuclear, rxr, acid, cell, cells, res, mol, biol, kim, differentiation, retinoic, osteoclast, remodeling, endocrinol, miner, role, vitamin, biochem, ricote, mice, metab, function, ligand, nat, clin, chen, chem, activation, formation, transcription, signaling, factor, peroxisome, regulation, genes, zhang, dois, doijbmr, ppargamma, lee,

Topics {✒️}

peroxisome proliferator-activated receptor/retinoid month download article/chapter peroxisome proliferator-activated receptors estrogen-induced bone-mass increase menendez-gutierrez mp receptor gamma-deficient mice menéndez-gutiérrez & mercedes ricote ppar-gamma regulates osteoclastogenesis article menéndez-gutiérrez extracellular matrix-related genes osteocyte-driven bone remodeling 9-cis retinoic acid 9-cis-retinoic acid xenobiotic receptor sxr nuclear receptor-independent pathways direct protein-protein interactions retinoid-induced bone thinning nuclear receptor heterodimers full article pdf ligand-dependent transcription factors nuclear hormone receptors multiple signaling pathways beta-catenin degradation trans retinoic acid enhanced bone resorption retinoic acid receptors relevant references owing receptor mafb specific rxr heterodimers thyroid hormone actions induced osteoclast differentiation rar signaling pathways bone marrow progenitors privacy choices/manage cookies receptor agonists bone remodelling basic research findings dna binding domain synergistic antitumor effect increase bone mass mesenchymal progenitor cells mesenchymal stem cells wnts’ fashion statement nuclear receptor expression cho sw article cellular de lera ar nur transcription factors srebp transcription factors unique response pathways

Questions {❓}

Wolf G (2006) Is 9-cis-retinoic acid the endogenous ligand for the retinoic acid-X receptor?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The multi-faceted role of retinoid X receptor in bone remodeling
         description:Retinoid X receptors (RXRs) form a unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs are obligatory partners for a number of other NRs, placing RXRs in a coordinating role at the crossroads of multiple signaling pathways. In addition, RXRs can function as self-sufficient homodimers. Recent advances have revealed RXRs as novel regulators of osteoclastogenesis and bone remodeling. This review outlines the versatility of RXR action in the control of transcription of bone-forming osteoblasts and bone-resorbing osteoclasts, both through heterodimerization with other NRs and through RXR homodimerization. RXR signaling is currently a major therapeutic target and, therefore, knowledge of how RXR signaling affects bone remodeling creates enormous potential for the translation of basic research findings into successful clinical therapies to increase bone mass and improve bone quality.
         datePublished:2017-01-19T00:00:00Z
         dateModified:2017-01-19T00:00:00Z
         pageStart:2135
         pageEnd:2149
         sameAs:https://doi.org/10.1007/s00018-017-2458-4
         keywords:
            Rexinoids
            9-cis retinoic acid
            Bexarotene
            Agonists
            Antagonists
            Homodimers
            Heterodimers
            Permissive
            MAFB
            Skeleton
            Bone resorption
            Osteoporosis
            Cell Biology
            Biomedicine
            general
            Life Sciences
            Biochemistry
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-017-2458-4/MediaObjects/18_2017_2458_Fig1_HTML.gif
         isPartOf:
            name:Cellular and Molecular Life Sciences
            issn:
               1420-9071
               1420-682X
            volumeNumber:74
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer International Publishing
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:María P. Menéndez-Gutiérrez
               affiliation:
                     name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
                     address:
                        name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mercedes Ricote
               url:http://orcid.org/0000-0002-8090-8902
               affiliation:
                     name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
                     address:
                        name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The multi-faceted role of retinoid X receptor in bone remodeling
      description:Retinoid X receptors (RXRs) form a unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs are obligatory partners for a number of other NRs, placing RXRs in a coordinating role at the crossroads of multiple signaling pathways. In addition, RXRs can function as self-sufficient homodimers. Recent advances have revealed RXRs as novel regulators of osteoclastogenesis and bone remodeling. This review outlines the versatility of RXR action in the control of transcription of bone-forming osteoblasts and bone-resorbing osteoclasts, both through heterodimerization with other NRs and through RXR homodimerization. RXR signaling is currently a major therapeutic target and, therefore, knowledge of how RXR signaling affects bone remodeling creates enormous potential for the translation of basic research findings into successful clinical therapies to increase bone mass and improve bone quality.
      datePublished:2017-01-19T00:00:00Z
      dateModified:2017-01-19T00:00:00Z
      pageStart:2135
      pageEnd:2149
      sameAs:https://doi.org/10.1007/s00018-017-2458-4
      keywords:
         Rexinoids
         9-cis retinoic acid
         Bexarotene
         Agonists
         Antagonists
         Homodimers
         Heterodimers
         Permissive
         MAFB
         Skeleton
         Bone resorption
         Osteoporosis
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-017-2458-4/MediaObjects/18_2017_2458_Fig1_HTML.gif
      isPartOf:
         name:Cellular and Molecular Life Sciences
         issn:
            1420-9071
            1420-682X
         volumeNumber:74
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:María P. Menéndez-Gutiérrez
            affiliation:
                  name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
                  address:
                     name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mercedes Ricote
            url:http://orcid.org/0000-0002-8090-8902
            affiliation:
                  name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
                  address:
                     name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cellular and Molecular Life Sciences
      issn:
         1420-9071
         1420-682X
      volumeNumber:74
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
      address:
         name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
         type:PostalAddress
      name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
      address:
         name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:María P. Menéndez-Gutiérrez
      affiliation:
            name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
            address:
               name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Mercedes Ricote
      url:http://orcid.org/0000-0002-8090-8902
      affiliation:
            name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
            address:
               name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
      name:Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(477)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.86s.

LINK . SPRINGER . COM {}