
NCBI . NLM . NIH . GOV {
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Title[redir]:
Examination of Nuclear Receptor Expression in Osteoblasts Reveals Rorβ as an Important Regulator of Osteogenesis - PMC
Description:
A complex network of transcription factors contributes to the establishment and maintenance of the osteoblastic phenotype. Although relatively few transcription factors, such as Runx2 and osterix, are essential to the process of osteoblastic ...
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Keywords {🔍}
expression, doi, rorβ, differentiation, bone, cells, pubmed, google, scholar, gene, osteoblastic, fig, genes, receptor, osteoblast, cell, data, mouse, runx, nuclear, pmc, mice, qpcr, osteoblasts, nrs, fold, article, hours, primary, mineralization, calvarial, free, function, model, osterix, orphan, analysis, receptors, performed, control, superfamily, marrow, mcte, important, transcription, day, compared, days, observed, system,
Topics {✒️}
c-terminal transactivation domains real-time quantitative pcr quantitative real-time pcr estrogen-related receptor gamma mc3t3-rorβ-gfp cell model mc3t3-rorβ-gfp model resulted retinoid-related orphan receptors synthetic rev-erb ligands pmc beta search fluorescence-activated cell sorting mc3t3-e1 mouse osteoblasts mouse mc3t3-e1 osteoblasts pcmv-cbfa1/runx2 expression constructs proliferating mc3t3-e1 cells mc3t3–rorβ-gfp cell models age-related bone loss mc3t3-e1 cells results dna-bound transcription factors rorβ ligand-binding pocket mouse-specific rorβ sirna combat age-related osteoporosis direct protein-dna interactions ligand-inducible transcription factors mesenchymal-enriched cell fraction high gfp-expressing cells c3h/hen mice homozygous express bone-related genes rorα-deficient mice uncovered rorβ-specific sirna resulted mc3t3-rorβ-gfp model mc3t3-gfp control model x-tremegene9 transfection reagent dna-binding domain mc3t3-rorβ-gfp cells pmc copyright notice rorβ-expressing cell system adipogenesis-related gene expression ligand binding domain cell-type-specific activation nihms344685-supplement-supp_fig_s1 nihms344685-supplement-supp_fig_s2 trans retinoic acid alizarin red staining rorβ-dependent runx2 antagonism runx2-dependent genes osteocalcin supplementary materials included early-acting factor rorβ-gfp cell models rorβ-gfp expression vectors age-related impairment
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