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We began analyzing https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12920-020-0661-x, but it redirected us to https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12920-020-0661-x. The analysis below is for the second page.

Title[redir]:
Comprehensive molecular characterization of inhibitors of apoptosis proteins (IAPs) for therapeutic targeting in cancer | BMC Medical Genomics | Full Text
Description:
Background Inhibitors of apoptosis proteins (IAPs) are a family of antiapoptotic proteins modulating cell cycle, signal transduction and apoptosis. Dysregulated IAPs have been reported to contribute to tumor progression and chemoresistance in various cancers. However, existing studies were sporadic and only focus on one specific cancer with one particular gene in the IAPs family. A systematic investigation on the co-expression pattern, regulation frameworks on various pathways, prognostic utility on patient outcomes, and predictive value on drug sensitivity among all the IAPs across multiple tumor types was lacking. Methods Leveraging The Cancer Genome Atlas data with comprehensive genomic characterizations on 9714 patients across 32 tumor types and the Genomics of Drug Sensitivity in Cancer data with both genomic characterizations and drug sensitivity data on > 1000 cell lines, we investigated the co-expression pattern of IAPs, their regulations of apoptosis as well as other pathways and clinical relevance of IAPs for therapeutics development. Results We discovered diverse expression pattern among IAPs, varied spectrum of apoptosis regulations through IAPs and extensive regulations beyond apoptosis involving immune response, cell cycle, gene expression and DNA damage repair. Importantly, IAPs were strong prognostic factors for patient survival and tumor stage in several tumor types including brain, liver, kidney, breast and lung cancer. Further, several IAPs were found to be predictive of sensitivity to BCL-2 inhibitors (BIRC3, BIRC5, BIRC6, and BIRC7) as well as RIPK1 inhibitors (BIRC3 and BIRC6). Conclusion Together, our work revealed the landscape of regulations, prognostic utilities and therapeutic relevance of IAPs across multiple tumor types.

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Keywords {🔍}

iaps, birc, expression, apoptosis, cancer, cancers, pubmed, cell, tumor, article, google, scholar, survival, sensitivity, pathways, cas, data, analysis, xiap, inhibitors, drug, types, regulations, signaling, pathway, gene, additional, fig, prognostic, file, genes, central, correlation, rest, pattern, identified, iap, associations, including, proteins, patient, multiple, stage, domain, coexpression, found, global, size, resistance, inhibitor,

Topics {✒️}

testis-specific iap/ts-iap/hilp-2 c-terminal ubiquitin-conjugating domain cellular iap2/ciap2/human iap1 cellular iap1/ciap1/human iap2 org/display/gdac/download ring-zinc finger domain personalized cancer therapy multi-modal molecular profilings large-scale genome sequencing author information authors gov/pmc/articles/pmc3514096/ re1-silencing transcription factor full size image high-throughput drug screening erk-mapki resistance group green dotted box applied log-rank test google scholar erk-mapki sensitive group springer nature state privacy rights red dotted box called ml-iap/kiap privacy choices/manage cookies acute myeloid leukemia cell line information pi3k/mtor signaling pathway authors scientific editing article liang cancer genome atlas cancer jianfeng liang additional information publisher anti-cancer drug development top anti-correlated mirnas optimal cluster size correlation-based distance cancer-iap regulation pairs x-linked iap/xiap manually curated pathways gene level results comprehensive molecular characterization cell lines coupled immortalized cell lines capital medical university renal cell carcinoma creative commons license comprehensive genomic characterizations showed anti-correlation molecular cancer therapy naip-birc2-birc3-xiap tetrad

Schema {🗺️}

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         description:Inhibitors of apoptosis proteins (IAPs) are a family of antiapoptotic proteins modulating cell cycle, signal transduction and apoptosis. Dysregulated IAPs have been reported to contribute to tumor progression and chemoresistance in various cancers. However, existing studies were sporadic and only focus on one specific cancer with one particular gene in the IAPs family. A systematic investigation on the co-expression pattern, regulation frameworks on various pathways, prognostic utility on patient outcomes, and predictive value on drug sensitivity among all the IAPs across multiple tumor types was lacking. Leveraging The Cancer Genome Atlas data with comprehensive genomic characterizations on 9714 patients across 32 tumor types and the Genomics of Drug Sensitivity in Cancer data with both genomic characterizations and drug sensitivity data on > 1000 cell lines, we investigated the co-expression pattern of IAPs, their regulations of apoptosis as well as other pathways and clinical relevance of IAPs for therapeutics development. We discovered diverse expression pattern among IAPs, varied spectrum of apoptosis regulations through IAPs and extensive regulations beyond apoptosis involving immune response, cell cycle, gene expression and DNA damage repair. Importantly, IAPs were strong prognostic factors for patient survival and tumor stage in several tumor types including brain, liver, kidney, breast and lung cancer. Further, several IAPs were found to be predictive of sensitivity to BCL-2 inhibitors (BIRC3, BIRC5, BIRC6, and BIRC7) as well as RIPK1 inhibitors (BIRC3 and BIRC6). Together, our work revealed the landscape of regulations, prognostic utilities and therapeutic relevance of IAPs across multiple tumor types.
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      headline:Comprehensive molecular characterization of inhibitors of apoptosis proteins (IAPs) for therapeutic targeting in cancer
      description:Inhibitors of apoptosis proteins (IAPs) are a family of antiapoptotic proteins modulating cell cycle, signal transduction and apoptosis. Dysregulated IAPs have been reported to contribute to tumor progression and chemoresistance in various cancers. However, existing studies were sporadic and only focus on one specific cancer with one particular gene in the IAPs family. A systematic investigation on the co-expression pattern, regulation frameworks on various pathways, prognostic utility on patient outcomes, and predictive value on drug sensitivity among all the IAPs across multiple tumor types was lacking. Leveraging The Cancer Genome Atlas data with comprehensive genomic characterizations on 9714 patients across 32 tumor types and the Genomics of Drug Sensitivity in Cancer data with both genomic characterizations and drug sensitivity data on > 1000 cell lines, we investigated the co-expression pattern of IAPs, their regulations of apoptosis as well as other pathways and clinical relevance of IAPs for therapeutics development. We discovered diverse expression pattern among IAPs, varied spectrum of apoptosis regulations through IAPs and extensive regulations beyond apoptosis involving immune response, cell cycle, gene expression and DNA damage repair. Importantly, IAPs were strong prognostic factors for patient survival and tumor stage in several tumor types including brain, liver, kidney, breast and lung cancer. Further, several IAPs were found to be predictive of sensitivity to BCL-2 inhibitors (BIRC3, BIRC5, BIRC6, and BIRC7) as well as RIPK1 inhibitors (BIRC3 and BIRC6). Together, our work revealed the landscape of regulations, prognostic utilities and therapeutic relevance of IAPs across multiple tumor types.
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      dateModified:2020-01-21T00:00:00Z
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Social Networks {👍}(2)

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