
NCBI . NLM . NIH . GOV {
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Title[redir]:
Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins - PMC
Description:
The heterogeneous group of diseases collectively termed cancer results not just from aberrant cellular proliferation but also from a lack of accompanying homeostatic cell death. Indeed, cancer cells regularly acquire resistance to programmed cell ...
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Keywords {🔍}
google, scholar, pubmed, doi, apoptosis, cancer, cell, pmc, article, free, inhibitor, protein, iap, smac, bir, death, cells, ciap, survivin, proteins, biol, reference, source, inhibitors, xiap, domain, expression, family, iaps, birc, caspase, mimetics, chem, clinical, tumor, gene, woa, patients, shown, livin, lcl, signaling, inhibition, role, phase, res, human, mliap, activity, binding,
Topics {✒️}
24th eortc-nci-aacr symposium apo-2l/trail-induced apoptosis drive nf-κb-mediated expression effective t-cell expansion/survival c-terminal leucine-rich repeat high-grade serous carcinomas nuclear factor-κb-inducing kinase small-molecule pan-iap antagonists pmc beta search ala-val-pro-ile tnf-related apoptosis-inducing ligand tnfr2-traf signaling complex dna-programmed chemistry library induced nf-kappab activation rgdv-functionalized nanodiamond carrier 3-dihydro-1h-indene compounds anti-survivin sirna delivered ubiquitin-protein ligase activity post-polycythemia vera myelofibrosis ligand-directed covalent modification collective structure-activity-relationship calcium-induced cell death c-terminal ubiquitin-conjugating vivo-active pro-apoptotic agents selective small-molecule antagonists tnfalpha-mediated cell death phase i-ii open-label rip1 protein-dependent assembly small-molecule smac mimetic extensively pre-clinically verified smac mimetic-induced degradation polyarginine-conjugated smac peptide potent small-molecule antagonist nf-κb signaling pathway hypericin-mediated photodynamic therapy spinal muscular atrophy degradative k63-branched ubiquitination enzalutamide-resistant prostate cancer adult t-cell leukemias sirna-mediated combined knockdown cell-line-based work clear-cell renal carcinomas tumor necrosis factor anti-apoptotic livin gene small-cell lung cancer smac mimetic-induced apoptosis progression-free survival viable anti-cancer strategy fas-induced cell death post-essential thrombocytosis myelofibrosis
Questions {❓}
- Kingeter LM, Schaefer BC: Malt1 and cIAP2-Malt1 as effectors of NF-kappaB activation: kissing cousins or distant relatives?
- MacKenzie A, LaCasse E: Inhibition of IAP's protection by Diablo/Smac: new therapeutic opportunities?
- Treat cancers by targeting survivin: just a dream or future reality?
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