We are analyzing https://link.springer.com/article/10.1007/s10495-017-1375-1.

Title:
Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs) | Apoptosis
Description:
Inhibitors of apoptosis (IAPs) are a family of proteins that play a significant role in the control of programmed cell death (PCD). PCD is essential to maintain healthy cell turnover within tissue but also to fight disease or infection. Uninhibited, IAPs can suppress apoptosis and promote cell cycle progression. Therefore, it is unsurprising that cancer cells demonstrate significantly elevated expression levels of IAPs, resulting in improved cell survival, enhanced tumor growth and subsequent metastasis. Therapies to target IAPs in cancer has garnered substantial scientific interest and as resistance to anti-cancer agents becomes more prevalent, targeting IAPs has become an increasingly attractive strategy to re-sensitize cancer cells to chemotherapies, antibody based-therapies and TRAIL therapy. Antagonism strategies to modulate the actions of XIAP, cIAP1/2 and survivin are the central focus of current research and this review highlights advances within this field with particular emphasis upon the development and specificity of second mitochondria-derived activator of caspase (SMAC) mimetics (synthetic analogs of endogenously expressed inhibitors of IAPs SMAC/DIABLO). While we highlight the potential of SMAC mimetics as effective single agent or combinatory therapies to treat cancer we also discuss the likely clinical implications of resistance to SMAC mimetic therapy, occasionally observed in cancer cell lines.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, google, scholar, article, cancer, cas, apoptosis, cell, cells, smac, death, resistance, xiap, central, expression, iaps, proteins, trail, ciap, protein, inhibitor, iap, mimetic, apoptotic, caspase, mimetics, intrinsic, pathway, mitochondrial, survivin, inhibitors, bcl, targeting, treatment, domain, tumor, therapy, activation, bir, signaling, pathways, receptor, chemotherapy, carcinoma, human, biol, bax, wang, clinical, activity,

Topics {✒️}

formic acid–phenylalanine–aline–alanine isoleucine–phenylalanine–valine–alanine iv tnf-related apoptosis-inducing ligand alanine–valine–phenylalanine–isoleucine bad trail/apo-2l-mediated apoptosis dietrich büsselberg alanine–valine–phenylalanine–isoleucine isoleucine–phenylalanine–valine–alanine multi-domain pro-apoptotic proteins clinical profile bax-/bax-deficient hct-116 cells mda-mb-231-txsa cells elizabeth varghese article download pdf mda-mb-txsa tumors x-linked lymphoproliferative syndrome kainic acid-induced injury bir-ubiquitin conjugating enzyme aggressive myc-driven lymphoma retro-inverse smac peptide polyarginine-conjugated smac peptide potent small-molecule antagonist anti-tumor antibiotic bleomycin endogenous smac/diablo exerts death-inducing signaling complex tnf-alpha dependent apoptosis constitutive nf-kb signaling tnfalpha-mediated cell death tnf-α-mediated apoptosis aberrant nf-kb activity increased cell-surface expression small-cell lung cancer cancer treatment profiles alternative nf-kappab pathways tnf-alpha-independent mechanism anti-apoptotic bcl-2 proteins bcl-2 anti-apoptotic proteins retro-inverse smac peptides retro-inverso smac peptides avpi n-terminal sequence h-bond charge affinity enhanced trail-induced apoptosis patient-derived xenograft models induce tnf-α production nf-kappab-dependent manner cancer pro-apoptotic factors apoptosis-inducing caspase-cascade anti-apoptotic bcl-2 members smac-mimetic-induced apoptosis trail-mediated dr5-disc formation

Questions {❓}

How best to target IAPs to overcome drug resistance?
How to tackle acquired resistance to IAP antagonism?
Van Roosmalen IA, Quax WJ, Kruyt FA (2014) Two death-inducing human TRAIL receptors to target in cancer: similar or distinct regulation and function?

Schema {🗺️}

WebPage:
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         headline:Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)
         description:Inhibitors of apoptosis (IAPs) are a family of proteins that play a significant role in the control of programmed cell death (PCD). PCD is essential to maintain healthy cell turnover within tissue but also to fight disease or infection. Uninhibited, IAPs can suppress apoptosis and promote cell cycle progression. Therefore, it is unsurprising that cancer cells demonstrate significantly elevated expression levels of IAPs, resulting in improved cell survival, enhanced tumor growth and subsequent metastasis. Therapies to target IAPs in cancer has garnered substantial scientific interest and as resistance to anti-cancer agents becomes more prevalent, targeting IAPs has become an increasingly attractive strategy to re-sensitize cancer cells to chemotherapies, antibody based-therapies and TRAIL therapy. Antagonism strategies to modulate the actions of XIAP, cIAP1/2 and survivin are the central focus of current research and this review highlights advances within this field with particular emphasis upon the development and specificity of second mitochondria-derived activator of caspase (SMAC) mimetics (synthetic analogs of endogenously expressed inhibitors of IAPs SMAC/DIABLO). While we highlight the potential of SMAC mimetics as effective single agent or combinatory therapies to treat cancer we also discuss the likely clinical implications of resistance to SMAC mimetic therapy, occasionally observed in cancer cell lines.
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         dateModified:2017-04-19T00:00:00Z
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      headline:Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)
      description:Inhibitors of apoptosis (IAPs) are a family of proteins that play a significant role in the control of programmed cell death (PCD). PCD is essential to maintain healthy cell turnover within tissue but also to fight disease or infection. Uninhibited, IAPs can suppress apoptosis and promote cell cycle progression. Therefore, it is unsurprising that cancer cells demonstrate significantly elevated expression levels of IAPs, resulting in improved cell survival, enhanced tumor growth and subsequent metastasis. Therapies to target IAPs in cancer has garnered substantial scientific interest and as resistance to anti-cancer agents becomes more prevalent, targeting IAPs has become an increasingly attractive strategy to re-sensitize cancer cells to chemotherapies, antibody based-therapies and TRAIL therapy. Antagonism strategies to modulate the actions of XIAP, cIAP1/2 and survivin are the central focus of current research and this review highlights advances within this field with particular emphasis upon the development and specificity of second mitochondria-derived activator of caspase (SMAC) mimetics (synthetic analogs of endogenously expressed inhibitors of IAPs SMAC/DIABLO). While we highlight the potential of SMAC mimetics as effective single agent or combinatory therapies to treat cancer we also discuss the likely clinical implications of resistance to SMAC mimetic therapy, occasionally observed in cancer cell lines.
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         Chemotherapy resistance
         Inhibitors of apoptosis proteins
         Combination therapy
         Intrinsic apoptotic pathway
         Extrinsic apoptotic pathway
         Cancer Research
         Cell Biology
         Oncology
         Biochemistry
         general
         Virology
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      name:Ana-Maria Florea
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               type:PostalAddress
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      name:Institute of Neuropathology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
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