We are analyzing https://link.springer.com/article/10.1186/1471-2407-9-125.

Title:
Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma | BMC Cancer
Description:
Background Similarly to other tumor types, an imbalance between unrestrained cell proliferation and impaired apoptosis appears to be a major unfavorable feature of hepatocellular carcinoma (HCC). The members of IAP family are key regulators of apoptosis, cytokinesis and signal transduction. IAP survival action is antagonized by specific binding of Smac/DIABLO and XAF1. This study aimed to investigate the gene and protein expression pattern of IAP family members and their antagonists in a series of human HCCs and to assess their clinical significance. Methods Relative quantification of IAPs and their antagonist genes was assessed by quantitative Real Time RT-PCR (qPCR) in 80 patients who underwent surgical resection for HCC. The expression ratios of XIAP/XAF1 and of XIAP/Smac were also evaluated. Survivin, XIAP and XAF1 protein expression were investigated by immunohistochemistry. Correlations between mRNA levels, protein expression and clinicopathological features were assessed. Follow-up data were available for 69 HCC patients. The overall survival analysis was estimated according to the Kaplan-Meier method. Results Survivin and Livin/ML-IAP mRNAs were significantly over-expressed in cancer tissues compared to non-neoplastic counterparts. Although Survivin immunoreactivity did not correlate with qPCR data, a significant relation was found between higher Survivin mRNA level and tumor stage, tumor grade and vascular invasion. The mRNA ratio XIAP/XAF1 was significantly higher in HCCs than in cirrhotic tissues. Moreover, high XIAP/XAF1 ratio was an indicator of poor prognosis when overall survival was estimated and elevated XIAP immunoreactivity was significantly associated with shorter survival. Conclusion Our study demonstrates that alterations in the expression of IAP family members, including Survivin and Livin/ML-IAP, are frequent in HCCs. Of interest, we could determine that an imbalance in XIAP/XAF1 mRNA expression levels correlated to overall patient survival, and that high XIAP immunoreactivity was a poor prognostic factor.
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Keywords {🔍}

expression, xiap, survivin, hcc, pubmed, article, xaf, google, scholar, patients, cancer, apoptosis, survival, high, tissue, carcinoma, cas, protein, cell, mrna, nonneoplastic, tumor, liver, analysis, immunoreactivity, hepatocellular, iap, smacdiablo, ratio, data, cirrhotic, cells, birc, hsm, iaps, gene, livinmliap, significantly, level, proteins, hccs, xiapxaf, levels, tissues, ciap, samples, study, human, factor, inhibitor,

Topics {✒️}

expression profile view valentina vaira matteo donadon roberto santambrogio nf-κb inhibitor dehydroxymethyl-epoxyquinomicin routinely hematoxylin-eosin-stained sections guido torzilli author correspondence single regulator open access article post-transcriptional regulatory mechanisms livin/ml-iap mrnas article download pdf livin/ml-iap mrna endogenous livin/ml-iap tumour histological features kaplan-meyer analysis demonstrated iap anti-apoptotic action livin/ml-iap α small-cell lung cancer software pre-processing steps pre-publication history indirectly sequesters smac/diablo livin/ml-iap overexpression anti-apoptotic properties kaplan-meier survival curves xiap anti-caspase activity contrary smac/diablo expression mrna ratio xiap/xaf1 antagonistic regulators reduced survivin expression istituto clinico humanitas prognosis livin/ml-iap xiap-smac/diablo interaction cell cycle research cirrhotic liver tissue privacy choices/manage cookies cirrhotic tissue close human hepatocellular carcinoma xiap/xaf1 expression ratio survivin mrna associates renal cell carcinoma full-length survivin disease-free survival curves 4 μm-thick section cirrhotic liver cells primary hepatocellular carcinoma hepatoma cell lines high xiap/xaf1 ratio

Schema {🗺️}

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         headline:Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma
         description:Similarly to other tumor types, an imbalance between unrestrained cell proliferation and impaired apoptosis appears to be a major unfavorable feature of hepatocellular carcinoma (HCC). The members of IAP family are key regulators of apoptosis, cytokinesis and signal transduction. IAP survival action is antagonized by specific binding of Smac/DIABLO and XAF1. This study aimed to investigate the gene and protein expression pattern of IAP family members and their antagonists in a series of human HCCs and to assess their clinical significance. Relative quantification of IAPs and their antagonist genes was assessed by quantitative Real Time RT-PCR (qPCR) in 80 patients who underwent surgical resection for HCC. The expression ratios of XIAP/XAF1 and of XIAP/Smac were also evaluated. Survivin, XIAP and XAF1 protein expression were investigated by immunohistochemistry. Correlations between mRNA levels, protein expression and clinicopathological features were assessed. Follow-up data were available for 69 HCC patients. The overall survival analysis was estimated according to the Kaplan-Meier method. Survivin and Livin/ML-IAP mRNAs were significantly over-expressed in cancer tissues compared to non-neoplastic counterparts. Although Survivin immunoreactivity did not correlate with qPCR data, a significant relation was found between higher Survivin mRNA level and tumor stage, tumor grade and vascular invasion. The mRNA ratio XIAP/XAF1 was significantly higher in HCCs than in cirrhotic tissues. Moreover, high XIAP/XAF1 ratio was an indicator of poor prognosis when overall survival was estimated and elevated XIAP immunoreactivity was significantly associated with shorter survival. Our study demonstrates that alterations in the expression of IAP family members, including Survivin and Livin/ML-IAP, are frequent in HCCs. Of interest, we could determine that an imbalance in XIAP/XAF1 mRNA expression levels correlated to overall patient survival, and that high XIAP immunoreactivity was a poor prognostic factor.
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      headline:Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma
      description:Similarly to other tumor types, an imbalance between unrestrained cell proliferation and impaired apoptosis appears to be a major unfavorable feature of hepatocellular carcinoma (HCC). The members of IAP family are key regulators of apoptosis, cytokinesis and signal transduction. IAP survival action is antagonized by specific binding of Smac/DIABLO and XAF1. This study aimed to investigate the gene and protein expression pattern of IAP family members and their antagonists in a series of human HCCs and to assess their clinical significance. Relative quantification of IAPs and their antagonist genes was assessed by quantitative Real Time RT-PCR (qPCR) in 80 patients who underwent surgical resection for HCC. The expression ratios of XIAP/XAF1 and of XIAP/Smac were also evaluated. Survivin, XIAP and XAF1 protein expression were investigated by immunohistochemistry. Correlations between mRNA levels, protein expression and clinicopathological features were assessed. Follow-up data were available for 69 HCC patients. The overall survival analysis was estimated according to the Kaplan-Meier method. Survivin and Livin/ML-IAP mRNAs were significantly over-expressed in cancer tissues compared to non-neoplastic counterparts. Although Survivin immunoreactivity did not correlate with qPCR data, a significant relation was found between higher Survivin mRNA level and tumor stage, tumor grade and vascular invasion. The mRNA ratio XIAP/XAF1 was significantly higher in HCCs than in cirrhotic tissues. Moreover, high XIAP/XAF1 ratio was an indicator of poor prognosis when overall survival was estimated and elevated XIAP immunoreactivity was significantly associated with shorter survival. Our study demonstrates that alterations in the expression of IAP family members, including Survivin and Livin/ML-IAP, are frequent in HCCs. Of interest, we could determine that an imbalance in XIAP/XAF1 mRNA expression levels correlated to overall patient survival, and that high XIAP immunoreactivity was a poor prognostic factor.
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               name:Department of Pathology, University of Milan, IRCCS Istituto Clinico Humanitas, Rozzano, Italy
               type:PostalAddress
            type:Organization
      name:Guido Coggi
      affiliation:
            name:University of Milan, AO S Paolo e Fondazione IRCCS Ospedale Maggiore Policlinico, Regina Elena e Mangiagalli
            address:
               name:Department of Medicine, Surgery and Dentistry, Division of Pathology, University of Milan, AO S Paolo e Fondazione IRCCS Ospedale Maggiore Policlinico, Regina Elena e Mangiagalli, Milan, Italy
               type:PostalAddress
            type:Organization
      name:Silvano Bosari
      affiliation:
            name:University of Milan, AO S Paolo e Fondazione IRCCS Ospedale Maggiore Policlinico, Regina Elena e Mangiagalli
            address:
               name:Department of Medicine, Surgery and Dentistry, Division of Pathology, University of Milan, AO S Paolo e Fondazione IRCCS Ospedale Maggiore Policlinico, Regina Elena e Mangiagalli, Milan, Italy
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Medicine, Surgery and Dentistry, Division of Pathology, University of Milan, AO S Paolo e Fondazione IRCCS Ospedale Maggiore Policlinico, Regina Elena e Mangiagalli, Milan, Italy
      name:Department of Pathology, University of Milan, IRCCS Istituto Clinico Humanitas, Rozzano, Italy
      name:Department of Medicine, Surgery and Dentistry, Division of Pathology, University of Milan, AO S Paolo e Fondazione IRCCS Ospedale Maggiore Policlinico, Regina Elena e Mangiagalli, Milan, Italy
      name:3rd Division of General Surgery, University of Milan School of Medicine, Istituto Clinico Humanitas IRCCS Rozzano, Milan, Italy
      name:3rd Division of General Surgery, University of Milan School of Medicine, Istituto Clinico Humanitas IRCCS Rozzano, Milan, Italy
      name:Division of Bilio-Pancreatic Surgery, AO S Paolo, Italy
      name:3rd Division of General Surgery, University of Milan School of Medicine, Istituto Clinico Humanitas IRCCS Rozzano, Milan, Italy
      name:Department of Medicine, Surgery and Dentistry, Division of Pathology, University of Milan, AO S Paolo e Fondazione IRCCS Ospedale Maggiore Policlinico, Regina Elena e Mangiagalli, Milan, Italy
      name:Department of Medicine, Surgery and Dentistry, Division of Pathology, University of Milan, AO S Paolo e Fondazione IRCCS Ospedale Maggiore Policlinico, Regina Elena e Mangiagalli, Milan, Italy
      name:Department of Pathology, University of Milan, IRCCS Istituto Clinico Humanitas, Rozzano, Italy
      name:Department of Medicine, Surgery and Dentistry, Division of Pathology, University of Milan, AO S Paolo e Fondazione IRCCS Ospedale Maggiore Policlinico, Regina Elena e Mangiagalli, Milan, Italy
      name:Department of Medicine, Surgery and Dentistry, Division of Pathology, University of Milan, AO S Paolo e Fondazione IRCCS Ospedale Maggiore Policlinico, Regina Elena e Mangiagalli, Milan, Italy

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