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We began analyzing https://www.nature.com/articles/s41581-018-0018-2, but it redirected us to https://www.nature.com/articles/s41581-018-0018-2. The analysis below is for the second page.

Title[redir]:
The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease | Nature Reviews Nephrology
Description:
Crosstalk between the gut microbiota and the host has attracted considerable attention owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly associated with hypertension and is characterized by immune dysregulation, metabolic disorder and sympathetic activation, which are all linked to gut dysbiosis and altered host–microbiota crosstalk. In this Review, we discuss the complex interplay between the brain, the gut, the microbiota and the kidney in CKD and hypertension and explain our brain–gut–kidney axis hypothesis for the pathogenesis of these diseases. Consideration of the role of the brain–gut–kidney axis in the maintenance of normal homeostasis and of dysregulation of this axis in CKD and hypertension could lead to the identification of novel therapeutic targets. In addition, the discovery of unique microbial communities and their associated metabolites and the elucidation of brain–gut–kidney signalling are likely to fill fundamental knowledge gaps leading to innovative research, clinical trials and treatments for CKD and hypertension. Increasing evidence suggests an important role of the gut microbiota in the development of hypertension and chronic kidney disease. In this Review, the authors explain their brain–gut–kidney axis hypothesis for the pathogenesis of these diseases.

Matching Content Categories {📚}

  • Health & Fitness
  • Education
  • Science

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Custom-built

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Traffic Estimate {📈}

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

pubmed, google, scholar, article, cas, central, kidney, gut, disease, hypertension, microbiota, chronic, nature, renal, intestinal, sci, patients, function, cell, ckd, physiol, nephrol, blood, microbial, cells, system, microbiome, clin, axis, dis, usa, med, host, int, immunol, immune, sympathetic, role, inflammation, bone, mice, pressure, nat, proc, natl, acad, development, fatty, rats, uremic,

Topics {✒️}

nature portfolio journals permissions reprints nature portfolio privacy policy renal β-adrenergic-wnk4 pathway short-chain fatty-acid binding innovative research attenuated portal hypertension ce-tofms-based metabolomics approach advertising il-17-producing t-helper cells tissue renin-angiotensin-aldosterone system short-chain fatty acids g-protein-coupled receptor ffar2 brain-kidney cross-talk social media middle-aged brain–gut–kidney axis hypothesis author correspondence exercise-induced stress behavior japan intrarenal renin-angiotensin system angiotensin ii-based hypertension butyrate-mediated histone acetylation intestinal bacteria-derived putrefactants enteroendocrine cells-sensory sentinels nature+ nature 486 nature 504 nature 535 nature 551 nature altered host–microbiota crosstalk end-stage renal disease hypothalamic-pituitary-adrenal system increased trimethylamine-n-oxide angiotensin ii-dependent hypertension energy-dense diet triggers long-term survivors bone marrow studies numerous protein-bound solutes brain–gut–kidney signalling blood-brain barrier disruption central nervous system gut-brain vagal communication brain–gut–kidney axis gut microbiota–brain axis gut-microbiota-brain axis indoxyl sulfate level glossary low-grade inflammation

Questions {❓}

  • Brain inflammation and hypertension: the chicken or the egg?
  • Do whole-grain oat cereals reduce the need for antihypertensive medications and improve blood pressure control?
  • Effect of AST-120 in chronic kidney disease treatment: still a controversy?
  • How informative is the mouse for human gut microbiota research?
  • What is the tryptophan kynurenine pathway and why is it important to neurotherapeutics?

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