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Title:
The gut microbiota and the brainâgutâkidney axis in hypertension and chronic kidney disease | Nature Reviews Nephrology
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Crosstalk between the gut microbiota and the host has attracted considerable attention owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly associated with hypertension and is characterized by immune dysregulation, metabolic disorder and sympathetic activation, which are all linked to gut dysbiosis and altered hostâmicrobiota crosstalk. In this Review, we discuss the complex interplay between the brain, the gut, the microbiota and the kidney in CKD and hypertension and explain our brainâgutâkidney axis hypothesis for the pathogenesis of these diseases. Consideration of the role of the brainâgutâkidney axis in the maintenance of normal homeostasis and of dysregulation of this axis in CKD and hypertension could lead to the identification of novel therapeutic targets. In addition, the discovery of unique microbial communities and their associated metabolites and the elucidation of brainâgutâkidney signalling are likely to fill fundamental knowledge gaps leading to innovative research, clinical trials and treatments for CKD and hypertension. Increasing evidence suggests an important role of the gut microbiota in the development of hypertension and chronic kidney disease. In this Review, the authors explain their brainâgutâkidney axis hypothesis for the pathogenesis of these diseases.
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nature portfolio journals permissions reprints nature portfolio privacy policy renal β-adrenergic-wnk4 pathway short-chain fatty-acid binding attenuated portal hypertension innovative research ce-tofms-based metabolomics approach advertising il-17-producing t-helper cells tissue renin-angiotensin-aldosterone system short-chain fatty acids g-protein-coupled receptor ffar2 brain-kidney cross-talk social media middle-aged brainâgutâkidney axis hypothesis exercise-induced stress behavior author correspondence japan intrarenal renin-angiotensin system angiotensin ii-based hypertension butyrate-mediated histone acetylation intestinal bacteria-derived putrefactants nature+ nature 486 nature 504 nature 535 nature 551 nature enteroendocrine cells-sensory sentinels altered hostâmicrobiota crosstalk end-stage renal disease hypothalamic-pituitary-adrenal system angiotensin ii-dependent hypertension increased trimethylamine-n-oxide energy-dense diet triggers long-term survivors bone marrow studies numerous protein-bound solutes brainâgutâkidney signalling blood-brain barrier disruption central nervous system gut-brain vagal communication brainâgutâkidney axis gut microbiotaâbrain axis gut-microbiota-brain axis indoxyl sulfate level glossary low-grade inflammation
Questions {â}
- Brain inflammation and hypertension: the chicken or the egg?
- Do whole-grain oat cereals reduce the need for antihypertensive medications and improve blood pressure control?
- Effect of AST-120 in chronic kidney disease treatment: still a controversy?
- How informative is the mouse for human gut microbiota research?
- What is the tryptophan kynurenine pathway and why is it important to neurotherapeutics?
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description:Crosstalk between the gut microbiota and the host has attracted considerable attention owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly associated with hypertension and is characterized by immune dysregulation, metabolic disorder and sympathetic activation, which are all linked to gut dysbiosis and altered hostâÂÂmicrobiota crosstalk. In this Review, we discuss the complex interplay between the brain, the gut, the microbiota and the kidney in CKD and hypertension and explain our brainâÂÂgutâÂÂkidney axis hypothesis for the pathogenesis of these diseases. Consideration of the role of the brainâÂÂgutâÂÂkidney axis in the maintenance of normal homeostasis and of dysregulation of this axis in CKD and hypertension could lead to the identification of novel therapeutic targets. In addition, the discovery of unique microbial communities and their associated metabolites and the elucidation of brainâÂÂgutâÂÂkidney signalling are likely to fill fundamental knowledge gaps leading to innovative research, clinical trials and treatments for CKD and hypertension. Increasing evidence suggests an important role of the gut microbiota in the development of hypertension and chronic kidney disease. In this Review, the authors explain their brainâÂÂgutâÂÂkidney axis hypothesis for the pathogenesis of these diseases.
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