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Title:
A reduction in the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii is associated with chronic kidney disease progression | Antonie van Leeuwenhoek
Description:
The human gut microbiota plays an important role in human health and might also be implicated in kidney disease. The interest in butyrate producing bacteria has recently increased and is a poorly understood faecal condition in chronic kidney disease (CKD). Therefore, we evaluated differences of the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii in the faeces of Chinese patients with CKD. A caseâcontrol study was carried out for 65 CKD patients and 20 healthy controls. Differences were quantitatively validated using quantitative real-time polymerase chain reaction (qPCR). Spearman rank correlation was used to analyse the correlation between gut microbiota and clinical variables. Roseburia spp. and F. prausnitzii were significantly different in CKD patients and controls (p = 0.001; p = 0.025, respectively) and reduced more markedly in end stage renal disease (p = 0.000; p = 0.003, respectively) and microinflammation (p = 0.004; p = 0.001, respectively). Roseburia spp. and F. prausnitzii were negatively associated with C-reactive protein in plasma (r = â0.493, p = 0.00; r = â0.528, p = 0.000; respectively) and Cystatin C (r = â0.321, p = 0.006; r = â0.445, p = 0.000; respectively). They were positively associated with eGFR (r = 0.347, p = 0.002; r = 0.416, p = 0.000; respectively). The negative correlation between Roseburia spp., F. prausnitzii and CRP and renal function suggested that the depletion of butyrate producing bacteria may contribute to CKD-associated inflammation and CKD progression. Roseburia spp. and F. prausnitzii may thus serve as âmicrobiomarkersâ.
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article, pubmed, google, scholar, disease, cas, kidney, chronic, gut, patients, microbiota, prausnitzii, nephrol, butyrate, roseburia, bacteria, inflammation, research, spp, faecalibacterium, ckd, renal, intestinal, vaziri, human, study, access, int, central, nature, microbial, privacy, cookies, function, content, producing, species, jiang, doi, china, publish, search, progression, xie, zhang, doiki, cardiovascular, intestine, doigutjnl, failure,
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cd4 + cd25bright + foxp3 + t-cells lishan zeng & ye chen c-reactive protein short-chain fatty acids butyrate-producing bacteria species month download article/chapter end-stage renal failure protein-bound uremic toxins butyrate producing bacteria butyrate-producing bacteria anti-inflammatory protein alters microbial flora full article pdf state key laboratory organ failure research translational research center commensal bacterium deficient privacy choices/manage cookies chronic renal failure altered intestinal microbiota chronic kidney disease related subjects ye chen inflammatory bowel disease gut microbiota profile gut microbiotaâmasters fecal microbial community p-cresyl sulphate medical ethics committee gut microbiota analysis gut flora metabolism european economic area caseâcontrol study de vinuesa sg 21st century challenge cross-sectional study wesson lg jr p-cresol-forming cross-sectional survey early gastrointestinal cancers southern medical university nephrol dial transplant conditions privacy policy article jiang gut bacterial translocation article log electronic supplementary material human large intestine accepting optional cookies spearman rank correlation
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headline:A reduction in the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii is associated with chronic kidney disease progression
description:The human gut microbiota plays an important role in human health and might also be implicated in kidney disease. The interest in butyrate producing bacteria has recently increased and is a poorly understood faecal condition in chronic kidney disease (CKD). Therefore, we evaluated differences of the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii in the faeces of Chinese patients with CKD. A caseâcontrol study was carried out for 65 CKD patients and 20 healthy controls. Differences were quantitatively validated using quantitative real-time polymerase chain reaction (qPCR). Spearman rank correlation was used to analyse the correlation between gut microbiota and clinical variables. Roseburia spp. and F. prausnitzii were significantly different in CKD patients and controls (p = 0.001; p = 0.025, respectively) and reduced more markedly in end stage renal disease (p = 0.000; p = 0.003, respectively) and microinflammation (p = 0.004; p = 0.001, respectively). Roseburia spp. and F. prausnitzii were negatively associated with C-reactive protein in plasma (r = â0.493, p = 0.00; r = â0.528, p = 0.000; respectively) and Cystatin C (r = â0.321, p = 0.006; r = â0.445, p = 0.000; respectively). They were positively associated with eGFR (r = 0.347, p = 0.002; r = 0.416, p = 0.000; respectively). The negative correlation between Roseburia spp., F. prausnitzii and CRP and renal function suggested that the depletion of butyrate producing bacteria may contribute to CKD-associated inflammation and CKD progression. Roseburia spp. and F. prausnitzii may thus serve as âmicrobiomarkersâ.
datePublished:2016-07-18T00:00:00Z
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Gut microbiota
Chronic kidney disease
Butyrate
C-reactive protein
Microbiology
Medical Microbiology
Plant Sciences
Soil Science & Conservation
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headline:A reduction in the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii is associated with chronic kidney disease progression
description:The human gut microbiota plays an important role in human health and might also be implicated in kidney disease. The interest in butyrate producing bacteria has recently increased and is a poorly understood faecal condition in chronic kidney disease (CKD). Therefore, we evaluated differences of the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii in the faeces of Chinese patients with CKD. A caseâcontrol study was carried out for 65 CKD patients and 20 healthy controls. Differences were quantitatively validated using quantitative real-time polymerase chain reaction (qPCR). Spearman rank correlation was used to analyse the correlation between gut microbiota and clinical variables. Roseburia spp. and F. prausnitzii were significantly different in CKD patients and controls (p = 0.001; p = 0.025, respectively) and reduced more markedly in end stage renal disease (p = 0.000; p = 0.003, respectively) and microinflammation (p = 0.004; p = 0.001, respectively). Roseburia spp. and F. prausnitzii were negatively associated with C-reactive protein in plasma (r = â0.493, p = 0.00; r = â0.528, p = 0.000; respectively) and Cystatin C (r = â0.321, p = 0.006; r = â0.445, p = 0.000; respectively). They were positively associated with eGFR (r = 0.347, p = 0.002; r = 0.416, p = 0.000; respectively). The negative correlation between Roseburia spp., F. prausnitzii and CRP and renal function suggested that the depletion of butyrate producing bacteria may contribute to CKD-associated inflammation and CKD progression. Roseburia spp. and F. prausnitzii may thus serve as âmicrobiomarkersâ.
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Gut microbiota
Chronic kidney disease
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C-reactive protein
Microbiology
Medical Microbiology
Plant Sciences
Soil Science & Conservation
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