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We are analyzing https://link.springer.com/article/10.1007/s10482-016-0737-y.

Title:
A reduction in the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii is associated with chronic kidney disease progression | Antonie van Leeuwenhoek
Description:
The human gut microbiota plays an important role in human health and might also be implicated in kidney disease. The interest in butyrate producing bacteria has recently increased and is a poorly understood faecal condition in chronic kidney disease (CKD). Therefore, we evaluated differences of the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii in the faeces of Chinese patients with CKD. A case–control study was carried out for 65 CKD patients and 20 healthy controls. Differences were quantitatively validated using quantitative real-time polymerase chain reaction (qPCR). Spearman rank correlation was used to analyse the correlation between gut microbiota and clinical variables. Roseburia spp. and F. prausnitzii were significantly different in CKD patients and controls (p = 0.001; p = 0.025, respectively) and reduced more markedly in end stage renal disease (p = 0.000; p = 0.003, respectively) and microinflammation (p = 0.004; p = 0.001, respectively). Roseburia spp. and F. prausnitzii were negatively associated with C-reactive protein in plasma (r = âˆ’0.493, p = 0.00; r = âˆ’0.528, p = 0.000; respectively) and Cystatin C (r = âˆ’0.321, p = 0.006; r = âˆ’0.445, p = 0.000; respectively). They were positively associated with eGFR (r = 0.347, p = 0.002; r = 0.416, p = 0.000; respectively). The negative correlation between Roseburia spp., F. prausnitzii and CRP and renal function suggested that the depletion of butyrate producing bacteria may contribute to CKD-associated inflammation and CKD progression. Roseburia spp. and F. prausnitzii may thus serve as ‘microbiomarkers’.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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What CMS is link.springer.com built with?

Custom-built

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

article, pubmed, google, scholar, disease, cas, kidney, chronic, gut, patients, microbiota, prausnitzii, nephrol, butyrate, roseburia, bacteria, inflammation, research, spp, faecalibacterium, ckd, renal, intestinal, vaziri, human, study, access, int, central, nature, microbial, privacy, cookies, function, content, producing, species, jiang, doi, china, publish, search, progression, xie, zhang, doiki, cardiovascular, intestine, doigutjnl, failure,

Topics {✒️}

cd4 + cd25bright + foxp3 + t-cells lishan zeng & ye chen c-reactive protein short-chain fatty acids butyrate-producing bacteria species month download article/chapter end-stage renal failure protein-bound uremic toxins butyrate producing bacteria butyrate-producing bacteria anti-inflammatory protein alters microbial flora full article pdf state key laboratory organ failure research translational research center commensal bacterium deficient privacy choices/manage cookies chronic renal failure altered intestinal microbiota chronic kidney disease related subjects ye chen inflammatory bowel disease gut microbiota profile gut microbiota–masters fecal microbial community p-cresyl sulphate medical ethics committee gut microbiota analysis gut flora metabolism european economic area case–control study de vinuesa sg 21st century challenge cross-sectional study wesson lg jr p-cresol-forming cross-sectional survey early gastrointestinal cancers southern medical university nephrol dial transplant conditions privacy policy article jiang gut bacterial translocation article log electronic supplementary material human large intestine accepting optional cookies spearman rank correlation

Schema {🗺️}

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         headline:A reduction in the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii is associated with chronic kidney disease progression
         description:The human gut microbiota plays an important role in human health and might also be implicated in kidney disease. The interest in butyrate producing bacteria has recently increased and is a poorly understood faecal condition in chronic kidney disease (CKD). Therefore, we evaluated differences of the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii in the faeces of Chinese patients with CKD. A case–control study was carried out for 65 CKD patients and 20 healthy controls. Differences were quantitatively validated using quantitative real-time polymerase chain reaction (qPCR). Spearman rank correlation was used to analyse the correlation between gut microbiota and clinical variables. Roseburia spp. and F. prausnitzii were significantly different in CKD patients and controls (p = 0.001; p = 0.025, respectively) and reduced more markedly in end stage renal disease (p = 0.000; p = 0.003, respectively) and microinflammation (p = 0.004; p = 0.001, respectively). Roseburia spp. and F. prausnitzii were negatively associated with C-reactive protein in plasma (r = −0.493, p = 0.00; r = −0.528, p = 0.000; respectively) and Cystatin C (r = −0.321, p = 0.006; r = −0.445, p = 0.000; respectively). They were positively associated with eGFR (r = 0.347, p = 0.002; r = 0.416, p = 0.000; respectively). The negative correlation between Roseburia spp., F. prausnitzii and CRP and renal function suggested that the depletion of butyrate producing bacteria may contribute to CKD-associated inflammation and CKD progression. Roseburia spp. and F. prausnitzii may thus serve as ‘microbiomarkers’.
         datePublished:2016-07-18T00:00:00Z
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            Medical Microbiology
            Plant Sciences
            Soil Science & Conservation
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      headline:A reduction in the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii is associated with chronic kidney disease progression
      description:The human gut microbiota plays an important role in human health and might also be implicated in kidney disease. The interest in butyrate producing bacteria has recently increased and is a poorly understood faecal condition in chronic kidney disease (CKD). Therefore, we evaluated differences of the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii in the faeces of Chinese patients with CKD. A case–control study was carried out for 65 CKD patients and 20 healthy controls. Differences were quantitatively validated using quantitative real-time polymerase chain reaction (qPCR). Spearman rank correlation was used to analyse the correlation between gut microbiota and clinical variables. Roseburia spp. and F. prausnitzii were significantly different in CKD patients and controls (p = 0.001; p = 0.025, respectively) and reduced more markedly in end stage renal disease (p = 0.000; p = 0.003, respectively) and microinflammation (p = 0.004; p = 0.001, respectively). Roseburia spp. and F. prausnitzii were negatively associated with C-reactive protein in plasma (r = −0.493, p = 0.00; r = −0.528, p = 0.000; respectively) and Cystatin C (r = −0.321, p = 0.006; r = −0.445, p = 0.000; respectively). They were positively associated with eGFR (r = 0.347, p = 0.002; r = 0.416, p = 0.000; respectively). The negative correlation between Roseburia spp., F. prausnitzii and CRP and renal function suggested that the depletion of butyrate producing bacteria may contribute to CKD-associated inflammation and CKD progression. Roseburia spp. and F. prausnitzii may thus serve as ‘microbiomarkers’.
      datePublished:2016-07-18T00:00:00Z
      dateModified:2016-07-18T00:00:00Z
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      sameAs:https://doi.org/10.1007/s10482-016-0737-y
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         Gut microbiota
         Chronic kidney disease
         Butyrate
         C-reactive protein
         Microbiology
         Medical Microbiology
         Plant Sciences
         Soil Science & Conservation
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            name:Southern Medical University, State Key Laboratory of Organ Failure Research, Ministry of Education
            address:
               name:Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, Ministry of Education, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:Ye Chen
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            name:Southern Medical University, State Key Laboratory of Organ Failure Research, Ministry of Education
            address:
               name:Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, Ministry of Education, Guangzhou, China
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      name:Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, Ministry of Education, Guangzhou, China
      name:Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, Ministry of Education, Guangzhou, China
      name:Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, Ministry of Education, Guangzhou, China
      name:Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, Ministry of Education, Guangzhou, China
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