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         headline:Mitotic catastrophe: a mechanism for avoiding genomic instability
         description:The improper distribution of chromosomes during mitosis can contribute to malignant transformation. Higher eukaryotes have developed strategies for eliminating mitosis-incompetent cells, one of which is mitotic catastrophe. From a functional perspective, mitotic catastrophe can be defined as an oncosuppressive mechanism that precedes (and is distinct from) apoptosis, necrosis or senescence. The improper distribution of chromosomes during mitosis compromises cellular functions and can reduce cellular fitness or contribute to malignant transformation. As a countermeasure, higher eukaryotes have developed strategies for eliminating mitosis-incompetent cells, one of which is mitotic catastrophe. Mitotic catastrophe is driven by a complex and poorly understood signalling cascade but, from a functional perspective, it can be defined as an oncosuppressive mechanism that precedes (and is distinct from) apoptosis, necrosis or senescence. Accordingly, the disruption of mitotic catastrophe precipitates tumorigenesis and cancer progression, and its induction constitutes a therapeutic endpoint.
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               type:PostalAddress
            type:Organization
      name:Guido Kroemer
      affiliation:
            name:Ilio Vitale, Lorenzo Galluzzi, Maria Castedo and Guido Kroemer are at the Institut National de la Santé et de la Recherche Médicale (INSERM), U848, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F-94805 Villejuif, France.
            address:
               name:Ilio Vitale, Lorenzo Galluzzi, Maria Castedo and Guido Kroemer are at the Institut National de la Santé et de la Recherche Médicale (INSERM), U848, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F-94805 Villejuif, France.,
               type:PostalAddress
            type:Organization
            name:Guido Kroemer is also at the Metabolomics Platform, Institut Gustave Roussy, F-94805 Villejuif, France; the Centre de Recherche des Cordeliers, F-75005 Paris, France; the Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, F-75908 Paris, France; and the Université Paris Descartes, Paris 5, F-75270 Paris, France.
            address:
               name:Guido Kroemer is also at the Metabolomics Platform, Institut Gustave Roussy, F-94805 Villejuif, France; the Centre de Recherche des Cordeliers, F-75005 Paris, France; the Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, F-75908 Paris, France; and the Université Paris Descartes, Paris 5, F-75270 Paris, France.,
               type:PostalAddress
            type:Organization
            name:the Centre de Recherche des Cordeliers, F-75005 Paris, France
            address:
               name:the Centre de Recherche des Cordeliers, F-75005 Paris, France,
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Ilio Vitale, Lorenzo Galluzzi, Maria Castedo and Guido Kroemer are at the Institut National de la Santé et de la Recherche Médicale (INSERM), U848, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F-94805 Villejuif, France.,
      name:Ilio Vitale, Lorenzo Galluzzi and Maria Castedo are also at the Institut Gustave Roussy, and the Université Paris-Sud, Paris 11, F-94805 Villejuif, France.,
      name:Ilio Vitale, Lorenzo Galluzzi, Maria Castedo and Guido Kroemer are at the Institut National de la Santé et de la Recherche Médicale (INSERM), U848, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F-94805 Villejuif, France.,
      name:Ilio Vitale, Lorenzo Galluzzi and Maria Castedo are also at the Institut Gustave Roussy, and the Université Paris-Sud, Paris 11, F-94805 Villejuif, France.,
      name:Ilio Vitale, Lorenzo Galluzzi, Maria Castedo and Guido Kroemer are at the Institut National de la Santé et de la Recherche Médicale (INSERM), U848, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F-94805 Villejuif, France.,
      name:Ilio Vitale, Lorenzo Galluzzi and Maria Castedo are also at the Institut Gustave Roussy, and the Université Paris-Sud, Paris 11, F-94805 Villejuif, France.,
      name:Ilio Vitale, Lorenzo Galluzzi, Maria Castedo and Guido Kroemer are at the Institut National de la Santé et de la Recherche Médicale (INSERM), U848, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F-94805 Villejuif, France.,
      name:Guido Kroemer is also at the Metabolomics Platform, Institut Gustave Roussy, F-94805 Villejuif, France; the Centre de Recherche des Cordeliers, F-75005 Paris, France; the Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, F-75908 Paris, France; and the Université Paris Descartes, Paris 5, F-75270 Paris, France.,
      name:the Centre de Recherche des Cordeliers, F-75005 Paris, France,
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

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