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Title[redir]:
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells - PMC
Description:
Aneuploidy, an incorrect chromosome number, is the leading cause of miscarriages and mental retardation in humans and is a hallmark of cancer. We examined the effects of aneuploidy on primary mouse cells by generating a series of cell lines that ...
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Keywords {🔍}
cell, cells, trisomic, doi, chromosome, lines, aneuploidy, google, scholar, proliferation, pubmed, fig, number, immortalization, mefs, euploid, aneuploid, chr, increased, mouse, additional, figs, chromosomes, expression, volume, pmc, robertsonian, presence, cultures, cancer, gene, passages, genes, analysis, average, extra, copy, tumor, embryos, due, increase, tumorigenesis, primary, article, size, passage, culture, science, tumors, translocations,
Topics {✒️}
low-level aneuploidy-inducing mutation double-linear fit model pmc beta search wild-type mice lacking chromosome segregation machinery supplementary material supp koch institute microscopy primary foreskin fibroblasts supporting online material mouse embryonic fibroblast supplementary materials included supplementary materials supp initiate tumor formation inhibits tumor formation publisher site pdf mouse embryonic fibroblasts mouse model expressing chromosome mis-segregation lines intersect represents primary nitrogen source united states government final edited form license information pmcid unique fluorescent color metaphase spreads prepared earlier contact inhibition flow cytometric profile acute lymphoblastic leukemia acute megakaryoblastic leukemia accelerated aging phenotype atypical ductal hyperplasias org/mus_musculus/index mit biomicro center final processed form cell lines derived gene expression pattern mammalian embryonic development [google scholar] 8 [google scholar] 10 [google scholar] 19 [google scholar] 20 [google scholar] 30 [google scholar] 41 dna replication index ts19 cell lines cell volume determination cumulative cell volume caused tumor formation primary mouse cells asynchronously growing trisomic
Questions {❓}
- How can we reconcile these results?
- This raises the question: If aneuploidy is so deleterious, why are most solid tumors aneuploid?
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