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Title[redir]:
Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos - PMC
Description:
Tetraploidy can constitute a metastable intermediate between normal diploidy and oncogenic aneuploidy. Here, we show that the absence of p53 is not only permissive for the survival but also for multipolar asymmetric divisions of tetraploid cells, ...
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Keywords {🔍}
cells, tetraploid, mos, cell, doi, pubmed, google, scholar, figure, subtetraploid, supplementary, clones, video, multipolar, centrosomes, unstable, hct, phase, pmc, dna, usa, centrosome, article, cancer, content, chromosome, type, instability, free, diploid, castedo, independent, control, cycle, meansem, file, expression, kroemer, protein, transfected, representative, download, avi, mitosis, divisions, oncogene, tumour, mice, experiments, survival,
Topics {✒️}
cl-xposure® x-ray films drug-free culture medium mitogen-activated protein kinase centrin–dsred fusion-encoding construct sigenome smart-pool m-003859 pmc beta search drug-free medium full-length movies proving serine–threonine kinase activity cancéropôle ile-de-france supplementary video s3 c-mos proto-oncogene product bamh1–not1 restriction fragment xho1–bamh1 restriction fragment mos–green fluorescent protein radio-induced cell death fluorescence-activated cell sorter p35-expressing parental cells mammary epithelial cells viral oncogene v-mos p53-deficient tetraploid cells pcr-bluntii-topo plasmid dna damage-induced apoptosis h2b–gfp-expressing cells site-directed mutagenesis genome-wide genetic analysis centrin–dsred-positive dots c-mos-deficient mice p53-dependent pathway cultures progressively accumulated adenoviral p53-mediated apoptosis supplementary videos s1 moloney sarcoma virus freshly facs-purified diploid glyceraldehyde-3-phosphate dehydrogenase aggressive tumour variants video legends emboj201011s9 supplementary figure s1 unfertilized mouse eggs colon carcinoma pires-hrgfp2 vector green fluorescent protein exerts genome-stabilizing effects supplementary videos s4 supplementary videos s7 facs-purified populations represented cyclin b2 component dna damage checkpoint facs-purified parental cells supplementary figure s3
Questions {❓}
- Sagata N (1997) What does Mos do in oocytes and somatic cells?
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